Glyxambi

Though rare, people who took linagliptin in clinical studies have reported inflammation of the pancreas (pancreatitis). It's not known if linagliptin can raise your risk of pancreatitis if you've had this problem before. Some common symptoms of an inflamed pancreas are upper stomach pain, fever, nausea, and vomiting. If you start to feel any of these symptoms, contact your prescriber right away. You might need to stop taking Glyxambi (empagliflozin / linagliptin).

• Risk factors: Not eating for a long period of time | After surgery | Sudden fever | Problems with pancreas | Stopping or lowering dose of insulin | Too much alcohol

People who have Type 2 diabetes and problems with pancreas are at higher risk for a condition called diabetic ketoacidosis (DKA). This is a condition when your body makes too much acid and it's more likely to occur when your blood sugar levels are dangerously high. There have been reports of people who experienced DKA after taking Glyxambi (empagliflozin / linagliptin).

Get medical help right away if you notice signs and symptoms of DKA, such as shortness of breath, vomiting, belly pain, and feeling very tired because this condition can be life-threatening. If your healthcare team thinks you might have DKA, they'll ask you to stop taking Glyxambi (empagliflozin / linagliptin).

• Risk factors: People age 65 years and older | History of kidney problems | Taking certain water pills (e.g., furosemide (Lasix)) | Low salt (sodium) diet

Glyxambi (empagliflozin / linagliptin) can cause low levels of fluids in the body because empagliflozin might cause you to urinate more. This can lead to dehydration, low blood pressure, or sudden kidney injury. Sometimes, the kidney problems can require hospitalization or dialysis. You might be at a higher risk for low fluid levels and their complications (e.g., low blood pressure) if you have kidney problems or are of older age. If you have any risk factors for low fluid levels, talk with your prescriber about how you can safely take Glyxambi (empagliflozin / linagliptin). You might need to get blood and urine tests done before or during treatment so your care team can check your kidney health. Speak with your prescriber if you feel dizzy, confused, chest pain, or notice you're urinating less than usual while taking Glyxambi (empagliflozin / linagliptin). These might be symptoms of dehydration, low blood pressure, or kidney problems.

Taking Glyxambi (empagliflozin / linagliptin) with certain other diabetes medications, such as insulin or a sulfonylurea, puts you at risk for dangerously low blood sugar levels. It's important to know how to recognize and treat low blood sugar. Symptoms of low blood sugar include feeling shaky, confused, or irritated. Carry glucose tablets or fast-acting sugars with you so you can treat low blood sugar when needed.

• Risk factors: History of urinary tract infections (UTIs) or genital yeast infections

Glyxambi (empagliflozin / linagliptin) might raise your risk of genital and urinary tract infections. These infections can include infections affecting the kidneys and yeast infections. Your risk of a yeast infection is higher if you've had frequent or long-term genital yeast infections in the past. In rare cases, these genital infections can be serious and life-threatening, and they might require hospitalization or surgery. Let your prescriber know if you have genital itching, pain while urinating, cloudy urine, or back pain. These can be signs of a genital yeast infection or kidney infection. Get medical attention immediately if you have symptoms of a more serious infection, like pain, swelling, or redness in the genital area, along with fever and weakness.

• Risk factors: History of allergy to DPP-4 inhibitors (or "gliptins") | History of allergy to SGLT2 inhibitors

Glyxambi (empagliflozin / linagliptin) can sometimes cause serious allergic reactions, such as rash, peeling or blistering skin, swelling, trouble breathing, and dizziness. These reactions are most common within the first 3 months of using this medication. Watch out for allergic reactions if you've had a reaction to a different DPP-4 inhibitor (also known as gliptins) like Januvia (sitagliptin). Before taking Glyxambi (empagliflozin / linagliptin), make sure to let your prescriber know about your medical history.

In some rare cases, some people taking linagliptin have experienced an itchy, blistering rash or other severe skin reactions. Typically, these blisters or sores go away once you stop taking the medication and get treatment for the rash.

If you experience an allergic reaction to Glyxambi (empagliflozin / linagliptin) or you experience itching skin, rash with blisters, or sores, stop the medication and get medical care right away.

People who take DPP-4 inhibitors, such as linagliptin in Glyxambi (empagliflozin / linagliptin), have experienced severe joint pain. This can happen anytime from a day to many years after starting this medication. For most people, the pain goes away after stopping the medication. If you experience any discomfort in your joints, speak to your care team right away.

• Risk factors: History of amputations | Peripheral artery disease (narrowed blood vessels) | Diabetic foot ulcers

Although rare, some people who took empagliflozin during clinical studies needed foot or leg amputations. The risk for this complication appears higher for people who've previously had an amputation or have blood circulation problems. In studies, the most common reasons for amputations for people who took this medication were peripheral artery disease and diabetic foot ulcers.

Let a healthcare professional know right away if you have any new pain, tenderness, sores, ulcers, or infections on your legs or feet. Your care team can recommend ways to manage these foot problems or treat them before they get worse. If you have diabetes, regularly visit your diabetes care team for foot exams.

• Risk factors: Heart failure | Heart problems | Kidney problems

If you've recently had a heart or kidney problem, let your prescriber know before starting Glyxambi (empagliflozin / linagliptin). Some studies show that there might be a chance that taking certain DPP-4 inhibitors might raise the risk for heart failure, especially if you're at high risk of a heart-related event (e.g., heart attack) or heart disease. But other studies seem to show conflicting evidence. More research is needed in this area for linagliptin in Glyxambi (empagliflozin / linagliptin). Let your prescriber know right away if you experience any symptoms of heart failure, such as trouble breathing, tiredness, swelling in your body, or sudden weight gain. Your prescriber might recommend that you go to the hospital and that you stop taking Glyxambi (empagliflozin / linagliptin).