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Glyxambi Coupon - Glyxambi 25mg/5mg tablet

Glyxambi

empagliflozin / linagliptin
Used for Diabetes Type 2
Used for Diabetes Type 2

Glyxambi (empagliflozin / linagliptin) is used to manage blood sugar levels in adults with Type 2 diabetes. It's a combination of 2 medications: empagliflozin (a sodium-glucose co-transporter 2 (SGLT2) inhibitor) and linagliptin (a dipeptidyl peptidase-4 (DPP-4) inhibitor). It lowers blood sugar by getting rid of extra sugar through your urine and helping your body make more insulin. Glyxambi (empagliflozin / linagliptin) is taken by mouth once daily. Some common side effects include urinary tract infections and upper respiratory tract infections.

Last reviewed on November 22, 2024
basics-icon

What is Glyxambi (empagliflozin / linagliptin)?

What is Glyxambi (empagliflozin / linagliptin) used for?

How Glyxambi (empagliflozin / linagliptin) works

Glyxambi (empagliflozin / linagliptin) is a combination of two medications.

Are you looking for information on Jardiance (empagliflozin) or Tradjenta (linagliptin) instead?

Drug Facts

Common BrandsGlyxambi
Drug ClassSGLT2 inhibitor / DPP-4 inhibitor
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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Avg retail price
$2242.43(save 73.36%)
GoodRx discount
$597.35
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What are the side effects of Glyxambi (empagliflozin / linagliptin)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Other Side Effects

  • Genital yeast infection
  • More urination
  • Feeling thirsty
  • Joint pain
  • Nausea
  • Diarrhea
  • Low blood sugar

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Inflamed pancreas: upper stomach pain, fever, nausea, vomiting
  • Ketoacidosis (too much blood acid): shortness of breath, vomiting, belly pain, dry skin and mouth, feeling very tired, fruity-smelling breath
  • Sudden kidney problems: urinating less than usual, swelling in the legs or feet
  • Low blood pressure: dizziness, lightheadedness, confusion
  • Serious genital infection: pain, swelling, or redness in the genital area, fever, weakness
  • Severe skin or allergic reactions: rash, blisters, sores, trouble breathing, swelling

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Dehydration—increased thirst, dry mouth, feeling faint or lightheaded, headache, dark yellow or brown urine
  • Diabetic ketoacidosis (DKA)—increased thirst or amount of urine, dry mouth, fatigue, fruity odor to breath, trouble breathing, stomach pain, nausea, vomiting
  • Genital yeast infection—redness, swelling, pain, or itchiness, odor, thick or lumpy discharge
  • Heart failure—shortness of breath, swelling of the ankles, feet, or hands, sudden weight gain, unusual weakness or fatigue
  • Infection or redness, swelling, tenderness, or pain in the genitals, or area from the genitals to the back of the rectum
  • Pancreatitis—severe stomach pain that spreads to your back or gets worse after eating or when touched, fever, nausea, vomiting
  • Redness, blistering, peeling or loosening of the skin, including inside the mouth
  • Severe joint pain
  • Urinary tract infection (UTI)—burning when passing urine, passing frequent small amounts of urine, bloody or cloudy urine, pain in the lower back or sides

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Glyxambi (empagliflozin / linagliptin)

thumbs-up

Pros

Combines two medications into one pill for convenience

Can lower the risk of death from heart attack or stroke in people with Type 2 diabetes and heart disease

Only taken once a day in the morning with or without food

Not likely to cause weight gain

thumbs-down

Cons

Not safe for use in people on dialysis

Not approved for people with Type 1 diabetes

Might cause you to urinate more often

pharmacist-tips

Pharmacist tips for Glyxambi (empagliflozin / linagliptin)

pharmacist
  • Glyxambi (empagliflozin / linagliptin) can lower your blood pressure, which can cause dizziness and lightheadedness. This is more likely to happen if you're suddenly standing up from a sitting or lying down position. Make sure to get up slowly from these positions while taking Glyxambi (empagliflozin / linagliptin).

    • Make sure you're drinking enough fluids every day to prevent dehydration from Glyxambi (empagliflozin / linagliptin). Not drinking fluids as often as usual, vomiting, diarrhea, or being ill can lead to dehydration and raise your risk of having low blood pressure. Contact your prescriber if you feel dehydrated while taking Glyxambi (empagliflozin / linagliptin).

      • Glyxambi (empagliflozin / linagliptin) can cause genital yeast infections or urinary tract infections. Make sure to practice good hygiene to lower your risk of these infections. Let your care team know right away if you experience pain while urinating, frequent urination, belly pain, blood in the urine, genital itching, or discharge from the genitals.

        • If you're scheduled for a surgery, let your primary care provider know ahead of time. Your prescriber might ask you to pause your treatment with Glyxambi (empagliflozin / linagliptin) for at least 3 days before your surgery. Follow up with your prescriber after surgery to discuss when you should restart Glyxambi (empagliflozin / linagliptin).

          • If you have nausea, vomiting, belly pain, tiredness, fruity breath, or trouble breathing, stop taking Glyxambi (empagliflozin / linagliptin) and get medical attention right away. These can be signs of a serious condition called ketoacidosis (high acid levels in the blood or urine), which sometimes can require treatment in the hospital.

            • It's important to have a healthy and balanced diet and exercise regularly to keep your blood sugar under control. Make sure to work with your care team on a diet and exercise plan while taking Glyxambi (empagliflozin / linagliptin).

              • Glyxambi (empagliflozin / linagliptin) can interact with some medications. Let your care team know what medications you're taking, including over-the-counter products and supplements, before you start Glyxambi (empagliflozin / linagliptin).

                faqs

                Frequently asked questions about Glyxambi (empagliflozin / linagliptin)

                Can you take Glyxambi (empagliflozin / linagliptin) and Ozempic (semaglutide) together?
                Experts don't recommend taking Glyxambi (empagliflozin / linagliptin) and Ozempic (semaglutide) together because they work in similar ways to lower blood sugar. Ozempic (semaglutide) is a GLP-1 receptor agonist, which mimics the GLP-1 hormone in your body to trigger insulin release and help you feel fuller. Linagliptin in Glyxambi is a DPP-4 inhibitor that prevents GLP-1 from breaking down, causing it to stick around longer. Research shows that combining linagliptin with Ozempic (semaglutide) doesn't provide additional benefits for controlling blood sugar.
                Can you take Glyxambi (empagliflozin / linagliptin) with metformin?
                Your diabetes care time might consider prescribing Glyxambi (empagliflozin / linagliptin) along with metformin if your blood sugar levels aren't controlled on metformin alone. Empagliflozin, linagliptin, and metformin work in different ways to control blood sugar levels. Trijardy XR is a combination medication that contains all three medications. Ask your care team if you have more questions about possible treatment plans for controlling blood sugar levels.
                Does Glyxambi (empagliflozin / linagliptin) cause weight loss?
                You might experience some weight loss when you take Glyxambi (empagliflozin / linagliptin). Empagliflozin in Glyxambi is an SGLT2 inhibitor and it helps your body remove extra sugar through your urine. This might lead to some modest weight loss for some people. However, the linagliptin part, a DPP-4 inhibitor, doesn’t typically cause weight loss. Talk with your healthcare team if you have more questions about how Glyxambi (empagliflozin / linagliptin) might affect body weight.
                How long does Glyxambi (empagliflozin / linagliptin) stay in your system?
                It takes about 2-3 days for empagliflozin and about 16 days for linagliptin to leave your body. These times are based on the half-lives of these medications. It might take shorter or longer for you depending on your medical conditions and other medications you're taking.
                How long does it take for Glyxambi (empagliflozin / linagliptin) to work?
                Empagliflozin in Glyxambi starts to help your body remove extra sugar through the urine within a day after your first dose. But it might take a few weeks before you see more noticeable effects of Glyxambi (empagliflozin / linagliptin) on your blood sugar levels. Results can vary for each person, so regularly follow up with your prescriber to check how you're doing with Glyxambi (empagliflozin / linagliptin).
                How well does Glyxambi (empagliflozin / linagliptin) work for Type 2 diabetes?
                One study showed that about 60% of people who took Glyxambi (empagliflozin / linagliptin) together with metformin reached the goal A1C level of less than 7% after 6 months of treatment. In addition, people had an average drop of 33 mg/dL to 36 mg/dL in their fasting blood sugar levels (before your first meal of the day) after taking Glyxambi (empagliflozin / linagliptin) with metformin for 6 months. Follow up with your prescriber to discuss how well Glyxambi (empagliflozin / linagliptin) is working to lower your blood sugar levels.
                Is Glyxambi (empagliflozin / linagliptin) safe?
                Glyxambi (empagliflozin / linagliptin) is safe for most people when it's taken as prescribed by your diabetes care team. The most common side effects of this medication are urinary tract infection upper respiratory tract infection. Rarely, it can cause more serious side effects, like dehydration and ketoacidosis, that can be life-threatening. Talk with your healthcare team if you have specific questions about the risks of taking Glyxambi (empagliflozin / linagliptin).
                Is there a generic for Glyxambi (empagliflozin / linagliptin)?
                No, there's not currently a generic available for Glyxambi (empagliflozin / linagliptin). It only comes as a brand-name medication.
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                What are the risks and warnings for Glyxambi (empagliflozin / linagliptin)?

                Glyxambi (empagliflozin / linagliptin) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                risk-warning

                Pancreas problems

                Though rare, people who took linagliptin in clinical studies have reported inflammation of the pancreas (pancreatitis). It's not known if linagliptin can raise your risk of pancreatitis if you've had this problem before. Some common symptoms of an inflamed pancreas are upper stomach pain, fever, nausea, and vomiting. If you start to feel any of these symptoms, contact your prescriber right away. You might need to stop taking Glyxambi (empagliflozin / linagliptin).

                risk-warning

                Ketoacidosis (too much acid in the blood)

                • Risk factors: Not eating for a long period of time | After surgery | Sudden fever | Problems with pancreas | Stopping or lowering dose of insulin | Too much alcohol

                  People who have Type 2 diabetes and problems with pancreas are at higher risk for a condition called diabetic ketoacidosis (DKA). This is a condition when your body makes too much acid and it's more likely to occur when your blood sugar levels are dangerously high. There have been reports of people who experienced DKA after taking Glyxambi (empagliflozin / linagliptin).

                  Get medical help right away if you notice signs and symptoms of DKA, such as shortness of breath, vomiting, belly pain, and feeling very tired because this condition can be life-threatening. If your healthcare team thinks you might have DKA, they'll ask you to stop taking Glyxambi (empagliflozin / linagliptin).

                  risk-warning

                  Low fluids in the body (leading to low blood pressure or dehydration, or kidney problems)

                  • Risk factors: People age 65 years and older | History of kidney problems | Taking certain water pills (e.g., furosemide (Lasix)) | Low salt (sodium) diet

                    Glyxambi (empagliflozin / linagliptin) can cause low levels of fluids in the body because empagliflozin might cause you to urinate more. This can lead to dehydration, low blood pressure, or sudden kidney injury. Sometimes, the kidney problems can require hospitalization or dialysis. You might be at a higher risk for low fluid levels and their complications (e.g., low blood pressure) if you have kidney problems or are of older age. If you have any risk factors for low fluid levels, talk with your prescriber about how you can safely take Glyxambi (empagliflozin / linagliptin). You might need to get blood and urine tests done before or during treatment so your care team can check your kidney health. Speak with your prescriber if you feel dizzy, confused, chest pain, or notice you're urinating less than usual while taking Glyxambi (empagliflozin / linagliptin). These might be symptoms of dehydration, low blood pressure, or kidney problems.

                    risk-warning

                    Low blood sugar with other diabetes medications

                    Taking Glyxambi (empagliflozin / linagliptin) with certain other diabetes medications, such as insulin or a sulfonylurea, puts you at risk for dangerously low blood sugar levels. It's important to know how to recognize and treat low blood sugar. Symptoms of low blood sugar include feeling shaky, confused, or irritated. Carry glucose tablets or fast-acting sugars with you so you can treat low blood sugar when needed.

                    risk-warning

                    Genital and urinary tract infections

                    • Risk factors: History of urinary tract infections (UTIs) or genital yeast infections

                      Glyxambi (empagliflozin / linagliptin) might raise your risk of genital and urinary tract infections. These infections can include infections affecting the kidneys and yeast infections. Your risk of a yeast infection is higher if you've had frequent or long-term genital yeast infections in the past. In rare cases, these genital infections can be serious and life-threatening, and they might require hospitalization or surgery. Let your prescriber know if you have genital itching, pain while urinating, cloudy urine, or back pain. These can be signs of a genital yeast infection or kidney infection. Get medical attention immediately if you have symptoms of a more serious infection, like pain, swelling, or redness in the genital area, along with fever and weakness.

                      risk-warning

                      Serious allergic or skin reactions

                      • Risk factors: History of allergy to DPP-4 inhibitors (or "gliptins") | History of allergy to SGLT2 inhibitors

                        Glyxambi (empagliflozin / linagliptin) can sometimes cause serious allergic reactions, such as rash, peeling or blistering skin, swelling, trouble breathing, and dizziness. These reactions are most common within the first 3 months of using this medication. Watch out for allergic reactions if you've had a reaction to a different DPP-4 inhibitor (also known as gliptins) like Januvia (sitagliptin). Before taking Glyxambi (empagliflozin / linagliptin), make sure to let your prescriber know about your medical history.

                        In some rare cases, some people taking linagliptin have experienced an itchy, blistering rash or other severe skin reactions. Typically, these blisters or sores go away once you stop taking the medication and get treatment for the rash.

                        If you experience an allergic reaction to Glyxambi (empagliflozin / linagliptin) or you experience itching skin, rash with blisters, or sores, stop the medication and get medical care right away.

                        risk-warning

                        Joint pain

                        People who take DPP-4 inhibitors, such as linagliptin in Glyxambi (empagliflozin / linagliptin), have experienced severe joint pain. This can happen anytime from a day to many years after starting this medication. For most people, the pain goes away after stopping the medication. If you experience any discomfort in your joints, speak to your care team right away.

                        risk-warning

                        Leg and foot amputations

                        • Risk factors: History of amputations | Peripheral artery disease (narrowed blood vessels) | Diabetic foot ulcers

                          Although rare, some people who took empagliflozin during clinical studies needed foot or leg amputations. The risk for this complication appears higher for people who've previously had an amputation or have blood circulation problems. In studies, the most common reasons for amputations for people who took this medication were peripheral artery disease and diabetic foot ulcers.

                          Let a healthcare professional know right away if you have any new pain, tenderness, sores, ulcers, or infections on your legs or feet. Your care team can recommend ways to manage these foot problems or treat them before they get worse. If you have diabetes, regularly visit your diabetes care team for foot exams.

                          risk-warning

                          Heart failure

                          • Risk factors: Heart failure | Heart problems | Kidney problems

                            If you've recently had a heart or kidney problem, let your prescriber know before starting Glyxambi (empagliflozin / linagliptin). Some studies show that there might be a chance that taking certain DPP-4 inhibitors might raise the risk for heart failure, especially if you're at high risk of a heart-related event (e.g., heart attack) or heart disease. But other studies seem to show conflicting evidence. More research is needed in this area for linagliptin in Glyxambi (empagliflozin / linagliptin). Let your prescriber know right away if you experience any symptoms of heart failure, such as trouble breathing, tiredness, swelling in your body, or sudden weight gain. Your prescriber might recommend that you go to the hospital and that you stop taking Glyxambi (empagliflozin / linagliptin).

                            dosage

                            Glyxambi (empagliflozin / linagliptin) dosage forms

                            The average cost for 90 tablets of 25mg/5mg of Glyxambi (empagliflozin / linagliptin) is $1823.20 with a free GoodRx coupon. This is 18.7% off the average retail price of $2242.43.
                            tablet
                            Tablet
                            DosageQuantityPrice as low asPrice per unit
                            10mg/5mg30 tablets$597.35$19.91
                            25mg/5mg90 tablets$1823.20$20.26

                            Typical dosing for Glyxambi (empagliflozin / linagliptin)

                            • Adults: The typical dose is 10 mg/5 mg (empagliflozin/linagliptin) by mouth once daily in the morning. If needed, your prescriber can raise your dose to a maximum of 25 mg/5 mg (empagliflozin/linagliptin) once daily in the morning.

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                            How much does Glyxambi (empagliflozin / linagliptin) cost?

                            To access savings, use a GoodRx coupon and pay just a fraction of the retail price.View prices & coupons
                            contraindications-icon

                            Glyxambi (empagliflozin / linagliptin) contraindications

                            Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Glyxambi (empagliflozin / linagliptin) will not be safe for you to take.
                            • People on dialysis

                            alternatives

                            What are alternatives to Glyxambi (empagliflozin / linagliptin)?

                            There are a number of medications that your doctor can prescribe in place of Glyxambi (empagliflozin / linagliptin). Compare a few possible alternatives below.
                            Glyxambi (empagliflozin / linagliptin)
                            Used for:
                            $597.35 Lowest GoodRx priceView Prices
                            Used for:
                            • Type 2 diabetes in adults

                            $119.99 Lowest GoodRx priceView Prices
                            Used for:
                            • Type 2 diabetes

                            • Lowering the risk of death due to heart problems in adults with Type 2 diabetes and heart disease

                            • Lowering the risk of hospitalization and death due to heart problems in adults with Type 2 diabetes and heart failure

                            • Lowering the risk of worsening kidney problems, hospitalization, and death due to heart problems in adults with Type 2 diabetes and chronic kidney disease (CKD)

                            $1822.47 Lowest GoodRx priceView Prices
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                            Pink Triangle Logo And 25 / 5 - Glyxambi 25mg-5mg Tablet
                            This medicine is Pink, Triangle Tablet Imprinted With "Logo" And "25/5".Pink Triangle Logo And 25 / 5 - Glyxambi 25mg-5mg Tablet

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                            References

                            Best studies we found
                            View All References (7)

                            Kasina, S. V. S. K., et al. (2022). Dipeptidyl peptidase IV (DPP IV) inhibitors. StatPearls.

                            National Kidney Foundation. (n.d.). Dialysis.

                            Nauck, M.A., et al. (2016). Addition of a dipeptidyl peptidase-4 inhibitor, sitagliptin, to ongoing therapy with the glucagon-like peptide-1 receptor agonist liraglutide: A randomized controlled trial in patients with type 2 diabetes. Diabetes, Obesity and Metabolism.

                            Office on Women's Health. (2021). Vaginal yeast infections. U.S. Department of Health and Human Services.

                            Samson, S. L., et al. (2023). American Association of Clinical Endocrinology Consensus Statement: Comprehensive Type 2 Diabetes Management Algorithm – 2023 Update. Endocrine Practice.

                            Singh, A. K., et al. (2019). Heart failure hospitalization with DPP-4 inhibitors: A systematic review and meta-analysis of randomized controlled trials. Indian Journal of Endocrinology and Metabolism.

                            You and Your Hormones. (2021). Insulin.

                            GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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