Glyxambi

Though rare, people who took linagliptin in clinical studies have reported inflammation of the pancreas (pancreatitis). It's not known if linagliptin can raise your risk of pancreatitis if you've had this problem before. Some common symptoms of an inflamed pancreas are upper stomach pain, fever, nausea, and vomiting. If you start to feel any of these symptoms, contact your prescriber right away. You might need to stop taking Glyxambi (empagliflozin / linagliptin).

People who have Type 2 diabetes and problems with pancreas are at higher risk for a condition called diabetic ketoacidosis (DKA). This is a condition when your body makes too much acid and it's more likely to occur when your blood sugar levels are dangerously high. There have been reports of people who experienced DKA after taking Glyxambi (empagliflozin / linagliptin).

Glyxambi (empagliflozin / linagliptin) can cause low levels of fluids in the body because empagliflozin might cause you to urinate more. This can lead to dehydration, low blood pressure, or sudden kidney injury. Sometimes, the kidney problems can require hospitalization or dialysis. You might be at a higher risk for low fluid levels and their complications (e.g., low blood pressure) if you have kidney problems or are of older age. If you have any risk factors for low fluid levels, talk with your prescriber about how you can safely take Glyxambi (empagliflozin / linagliptin). You might need to get blood and urine tests done before or during treatment so your care team can check your kidney health. Speak with your prescriber if you feel dizzy, confused, chest pain, or notice you're urinating less than usual while taking Glyxambi (empagliflozin / linagliptin). These might be symptoms of dehydration, low blood pressure, or kidney problems.

Taking Glyxambi (empagliflozin / linagliptin) with certain other diabetes medications, such as insulin or a sulfonylurea, puts you at risk for dangerously low blood sugar levels. It's important to know how to recognize and treat low blood sugar. Symptoms of low blood sugar include feeling shaky, confused, or irritated. Carry glucose tablets or fast-acting sugars with you so you can treat low blood sugar when needed.

Glyxambi (empagliflozin / linagliptin) might raise your risk of genital and urinary tract infections. These infections can include infections affecting the kidneys and yeast infections. Your risk of a yeast infection is higher if you've had frequent or long-term genital yeast infections in the past. In rare cases, these genital infections can be serious and life-threatening, and they might require hospitalization or surgery. Let your prescriber know if you have genital itching, pain while urinating, cloudy urine, or back pain. These can be signs of a genital yeast infection or kidney infection. Get medical attention immediately if you have symptoms of a more serious infection, like pain, swelling, or redness in the genital area, along with fever and weakness.

Glyxambi (empagliflozin / linagliptin) can sometimes cause serious allergic reactions, such as rash, peeling or blistering skin, swelling, trouble breathing, and dizziness. These reactions are most common within the first 3 months of using this medication. Watch out for allergic reactions if you've had a reaction to a different DPP-4 inhibitor (also known as gliptins) like Januvia (sitagliptin). Before taking Glyxambi (empagliflozin / linagliptin), make sure to let your prescriber know about your medical history.

People who take DPP-4 inhibitors, such as linagliptin in Glyxambi (empagliflozin / linagliptin), have experienced severe joint pain. This can happen anytime from a day to many years after starting this medication. For most people, the pain goes away after stopping the medication. If you experience any discomfort in your joints, speak to your care team right away.

Although rare, some people who took empagliflozin during clinical studies needed foot or leg amputations. The risk for this complication appears higher for people who've previously had an amputation or have blood circulation problems. In studies, the most common reasons for amputations for people who took this medication were peripheral artery disease and diabetic foot ulcers.