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Compare Glucovance vs. Jardiance

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Glucovance (glyburide/metformin) and Jardiance (empagliflozin) are both medications used to manage Type 2 diabetes, but they some differences between them. Glucovance combines glyburide, which stimulates insulin release, and metformin, which works to reduces sugar production and absorption. Jardiance helps your kidneys remove excess sugar through your urine. Unlike Jardiance, Glucovance is available as a lower-cost generic. It's best to take Glucovance with meals to avoid low blood sugar and stomach upset. Jardiance can be taken once daily, with or without food. Jardiance also offers additional benefits for adults with heart failure and chronic kidney disease. And taking Jardiance can increase your risk of urinary tract and yeast infections. Both medications can cause low blood sugar, especially when combined with other diabetes treatments, but this risk is higher in people taking Glucovance.

  • Glyburide/metformin
    Jardiance (empagliflozin)
  • Glyburide/metformin
    Jardiance (empagliflozin)

  • Summary of Glucovance vs. Jardiance

    Summary for Sulfonylurea / Biguanide
    Prescription only

    Glyburide/metformin is used to manage blood sugar levels in adults with Type 2 diabetes. It works best when taken with a healthy diet and regular exercise. This medication combines a sulfonylurea (glyburide) and a biguanide (metformin). You take it by mouth, typically once or twice daily with meals. Since glyburide/metformin can cause hypoglycemia (low blood sugar), it's important to carry fast-acting sugars like gummy candy or fruit juice to quickly raise your blood sugar if needed. Other common side effects include diarrhea, headache, and nausea. Brand name Glucovance has been discontinued.

    Summary for SGLT2 inhibitor
    Prescription only

    Jardiance (empagliflozin) is a brand-name medication that's used along with a nutritious diet and routine exercise to improve blood sugar levels in people 10 years and older with Type 2 diabetes. It can also lower the chance of serious complications, hospitalization, and death in certain adults with heart failure or chronic kidney disease (CKD). Jardiance (empagliflozin) belongs to the drug class called sodium-glucose cotransporter 2 (SGLT2) inhibitors. It's a tablet that's taken by mouth once a day. Side effects can include urinary tract infections (UTIs), yeast infections, and weight loss.

  • Indications of Glucovance vs. Jardiance

    Indications for
    •Type 2 diabetes (T2D) in adults
    Indications for
    •Type 2 diabetes (in addition to diet and exercise) in people age 10 years and older
    •Lowering the risk of death due to heart problems in adults with Type 2 diabetes and heart disease
    •Lowering the risk of hospitalization and death due to heart problems in adults with heart failure
    •Lowering the risk of worsening kidney problems, hospitalization, and death due to heart problems in adults with chronic kidney disease (CKD)

  • Pros and Cons of Glucovance vs. Jardiance

    Pros and Const for Sulfonylurea / Biguanide
    Pros
    •Combines two medications into one pill for convenience
    •Dose can be adjusted if needed
    •Taken by mouth instead of an injection
    Cons
    •Need to take with meals
    •Not safe for use in people with moderate-to-severe kidney disease
    •More likely to cause weight gain compared to some other medications for diabetes
    Pros and Const for SGLT2 inhibitor
    Pros
    •Taken by mouth once a day
    •Unlikely to cause weight gain
    •Can take with other diabetes medications
    Cons
    •Raises risk of urinary tract infections (UTIs) and genital yeast infections
    •Might make you urinate more
    •Not recommended during the second and third trimesters of pregnancy

  • Common Side Effects of Glucovance vs. Jardiance

    Common Side Effects for
    •Low blood sugar levels (up to 38%)
    •Diarrhea (17%)
    •Headache (9%)
    •Nausea or vomiting (8%)
    •Belly pain (7%)
    •Dizziness (6%)
    Common Side Effects for
    •Urinary tract infection (UTI; 8-9%)
    •Vaginal yeast infection in females (5-6%)
    •Upper respiratory tract infection (3-4%)
    •High cholesterol or fat levels (3-4%)
    •Urinating more than usual (3%)

  • Warnings of Glucovance vs. Jardiance

    Common Side Effects for
    •Lactic acidosis (too much acid in your body)
    •Low blood sugar
    •Possible risk of serious heart problems
    •Risk of low red blood cell count (hemolytic anemia)
    •Low vitamin B12 levels
    Common Side Effects for
    •Ketoacidosis
    •Low fluids in the body (leading to low blood pressure or dehydration)
    •Genital and urinary tract infections
    •Low blood sugar (hypoglycemia) when used with certain other diabetes medications
    •Leg and foot amputations
    •Allergic reactions

  • Prices with our coupons for Glucovance vs. Jardiance

    Learn more about Glyburide/metformin
    Learn more about Jardiance

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