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GLP-1s are a class of medications used for weight loss and to treat Type 2 diabetes. Some are also approved for cardiovascular, kidney, liver, and obstructive sleep apnea benefits. GLP-1 stands for glucagon-like peptide-1, a natural hormone that helps regulate blood sugar, digestion, and appetite.

GLP-1 receptor agonists mimic the body’s GLP-1 hormone. They stimulate the pancreas to release more insulin after meals, reduce how much sugar the liver makes, slow down digestion, and signal the brain to decrease hunger and promote fullness. These effects help lower blood sugar and reduce appetite. Some GLP-1 medications also act like a second hormone called glucose-dependent insulinotropic polypeptide (GIP) for additive effects.

GLP-1s are generally safe for many, but not for everyone. They should be avoided if you have a personal or family history of medullary thyroid cancer, or if you have multiple endocrine neoplasia syndrome type 2. They may not be recommended if you have a history of pancreatitis, severe gastrointestinal issues (like gastroparesis), or if you’re pregnant or nursing. The decision to take GLP-1 medications for weight loss should be made together with a licensed healthcare provider.

Insurance coverage for GLP-1s like Wegovy and Zepbound for weight loss varies. It can depend on your specific insurance plan, which GLP-1 you’re prescribed, and your health history. Coverage may be less likely when these medications are used for weight loss alone. But if you also have heart disease, obstructive sleep apnea, or metabolic dysfunction-associated steatohepatitis (a type of fatty liver disease), you may be more likely to get coverage. GoodRx Care Direct for weight loss helps you get GLP-1 medication at some of the lowest out-of-pocket prices available.

People often notice reduced appetite quickly after starting GLP-1 medications like Wegovy or Zepbound—within days to weeks. During clinical trials, people lost about 2% to 3% of their starting body weight during the first 4 weeks. Most weight loss often occurs within the first 4 to 5 months, continuing more gradually over the first year before leveling off.

There are a number of options for getting GLP-1s online. GoodRx Care Direct offers unlimited access to licensed healthcare professionals who can write a prescription for GLP-1 weight loss medication if it is a good fit for you, plus provide ongoing support to help you reach the most effective dose.

If you’ve already got a prescription for GLP-1 weight loss medication, you have two options: You can still use GoodRx Care Direct to get access to licensed healthcare professionals who can help you if you are still working your way up to your most effective dose (also known as “titrating”) and provide support for side effects or other medication concerns. Alternatively, you can use a GoodRx coupon at your pharmacy to get Wegovy or Zepbound pens at a discount. Zepbound vials are also available from the manufacturer’s website.