Key takeaways
Glyburide / metformin and insulin lispro (Humalog) are both medications used to manage blood sugar levels in people with diabetes. Glyburide / metformin is specifically approved for Type 2 diabetes, while insulin lispro is used for both Type 1 and Type 2 diabetes. Glyburide / metformin is a combination of a sulfonylurea and a biguanide, taken orally, and works by increasing insulin release and reducing sugar production in the liver. It used to be available as the brand name Glucovance. Insulin lispro, on the other hand, is a fast-acting insulin injected under the skin, helping your body absorb sugar after meals. Glyburide/metformin is typically taken once or twice daily with meals, whereas insulin lispro is injected multiple times a day, usually before meals. Glyburide/metformin can cause side effects like low blood sugar, diarrhea, and nausea, while insulin lispro may lead to low blood sugar, weight gain, and injection site reactions. Glyburide/metformin is not suitable for people with severe kidney issues, while insulin lispro should not be used when blood sugar is already low.
