Compare Glyset vs. Metformin

Miglitol (Glyset) and metformin (Glucophage) are both oral medications used to manage type 2 diabetes, but they work differently and have distinct characteristics. Miglitol slows the breakdown of carbohydrates, helping to prevent high blood sugar after meals. In contrast, metformin lowers the amount of sugar your body makes and absorbs and helps your body use insulin better. Miglitol is taken three times daily with meals, while metformin is usually taken once or twice daily, often with food to reduce stomach upset. Metformin is a first-choice medication and is known to lower the risk of death from diabetes-related complications. On the other hand, miglitol is not a first-choice medication because it doesn't lower A1C levels as effectively as metformin. Both medications can cause side effects like gas, nausea, and diarrhea. Neither medication is likely to cause low blood sugar or weight gain, and shouldn’t be used in people with kidney problems. Additionally, miglitol shouldn’t be used in people who have stomach problems like inflammatory bowel disease or problems with digesting food.