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Compare Metaglip vs. Glyburide

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Glipizide/metformin (Metaglip) and glyburide (Glynase) are medications used to treat Type 2 diabetes. Both help lower blood sugar, but they have several differences between them. Glipizide/metformin is a combination of glipizide and metformin. Both medications work by telling your pancreas to release insulin, but glipizide/metformin also reduces the amount of sugar your body makes and absorbs. Glipizide/metformin is usually taken once or twice daily, and can cause side effects like diarrhea and lactic acidosis. Glyburide is taken once daily with the largest meal and can cause side weight gain. Unlike glipizide/metformin, glyburide has a formulation that is absorbed better by the body. Both medications are available as low-cost generics and carry risks of heart problems and low blood sugar, but glipizide/metformin also has an increased risk of low vitamin B12 levels.

  • Glipizide/metformin
    Glyburide
  • Glipizide/metformin
    Glyburide

  • Summary of Metaglip vs. Glyburide

    Summary for Sulfonylurea / Biguanide
    Prescription only

    Glipizide/metformin combines two diabetes medications into one tablet: glipizide (a sulfonylurea) and metformin (a biguanide). It's approved to treat Type 2 diabetes in adults along with diet and exercise. This medication is typically taken by mouth once or twice a day. Some common side effects of glipizide/metformin can include diarrhea and headache; it isn't likely to cause weight gain or weight loss.

    Summary for Sulfonylurea
    Prescription only

    Glyburide is taken by mouth to lower blood sugar levels for people who have Type 2 diabetes. This medication isn't meant to be taken alone, but in addition to eating a healthy diet and engaging in regular exercise. Glyburide is typically taken once or twice daily, depending on your dose.

  • Indications of Metaglip vs. Glyburide

    Indications for
    •Type 2 diabetes
    Indications for
    •Type 2 diabetes

  • Pros and Cons of Metaglip vs. Glyburide

    Pros and Const for Sulfonylurea / Biguanide
    Pros
    •Taken by mouth
    •Combination medication, so more convenient to take
    •Available as a lower-cost generic
    Cons
    •Need to take with meals
    •Can't take during pregnancy
    •Not an option for children
    Pros and Const for Sulfonylurea
    Pros
    •Usually taken only once daily with largest meal
    •Can lower A1C levels by 1.5%
    •Taken by mouth, so good option for people who don't like injections
    •Can be taken with some other blood sugar medications, such as metformin
    Cons
    •Risk of low blood sugar (hypoglycemia), especially if you have kidney or liver problems
    •More likely to cause low blood sugar than other blood sugar medications, such as metformin
    •Can cause some weight gain
    •Not approved for Type 1 diabetes

  • Common Side Effects of Metaglip vs. Glyburide

    Common Side Effects for
    •Diarrhea (18%)
    •Headache (13%)
    •Cold or flu infection (10%)
    •Low blood sugar levels (9%)
    •Muscle pain (8%)
    •Nausea, vomiting (8%)
    •Stomach pain (6%)
    •Dizziness (5%)
    Common Side Effects for
    •Feeling bloated
    •Nausea
    •Heartburn

  • Warnings of Metaglip vs. Glyburide

    Common Side Effects for
    •Lactic acidosis
    •Possible risk of serious heart problems
    •Low blood sugar levels
    •Low vitamin B12 levels
    Common Side Effects for
    •Low blood sugar (hypoglycemia)
    •Possible risk of heart problems
    •Breakdown of red blood cells

  • Prices with our coupons for Metaglip vs. Glyburide

    Learn more about Glipizide/metformin
    Learn more about Glyburide

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