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Compare Glyxambi vs. Invokamet

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Glyxambi (empagliflozin/linagliptin) and Invokamet (canagliflozin/metformin) are both combination medications used to treat Type 2 diabetes, but they have some key differences. Glyxambi combines an SGLT2 inhibitor (empagliflozin) and a DPP-4 inhibitor (linagliptin), while Invokamet combines an SGLT2 inhibitor (canagliflozin) and a biguanide (metformin). Glyxambi is taken once daily, whereas Invokamet is available in both immediate-release (taken twice daily) and extended-release (taken once daily) forms. Glyxambi can lower the risk of death from heart disease in people with Type 2 diabetes and heart disease, which Invokamet is also approved for. Invokamet can also lower the risk of major heart events and hospitalization for heart failure and worsening kidney problems in adults with type 2 diabetes and kidney disease. Both medications can cause urinary tract infections and genital infections, but Invokamet also raises the risk of bone fractures and low vitamin B12 levels. Additionally, Invokamet is only available as a brand-name medication, while Glyxambi does not have a generic form either.

Glyxambi (empagliflozin / linagliptin)
Invokamet (canagliflozin / metformin)
Glyxambi (empagliflozin / linagliptin)
Invokamet (canagliflozin / metformin)
Summary of Glyxambi vs. Invokamet
Summary for SGLT2 inhibitor / DPP-4 inhibitor
Prescription only
Glyxambi (empagliflozin / linagliptin) is used to manage blood sugar levels in adults with Type 2 diabetes. It's a combination of 2 medications: empagliflozin (a sodium-glucose co-transporter 2 (SGLT2) inhibitor) and linagliptin (a dipeptidyl peptidase-4 (DPP-4) inhibitor). It lowers blood sugar by getting rid of extra sugar through your urine and helping your body make more insulin. Glyxambi (empagliflozin / linagliptin) is taken by mouth once daily. Some common side effects include urinary tract infections and upper respiratory tract infections.
Summary for SGLT2 inhibitor / Biguanide
Prescription only
Invokamet (canagliflozin / metformin) is a combination medication used along with diet and exercise to lower blood sugar levels in adults with Type 2 diabetes. It's available as immediate-release tablets that are taken twice daily, as well as extended-release tablets that are taken once daily. This medication raises the risk of urinary tract infections (UTIs) and genital infections.
Indications of Glyxambi vs. Invokamet
Indications for

•Type 2 diabetes in adults (when taken along with nutritious diet and regular exercise)

•Lowers risk of death from heart problems in adults with Type 2 diabetes and heart disease

Indications for

•Type 2 diabetes

•To lower the risk of major heart events (e.g., heart attack, stroke) in adults with Type 2 diabetes and heart disease

•To lower the risk of hospitalization for heart failure, death due to heart problems, and worsening of kidney problems in certain adults with Type 2 diabetes and diabetic kidney disease
Pros and Cons of Glyxambi vs. Invokamet
Pros and Const for SGLT2 inhibitor / DPP-4 inhibitor
Pros

•Combines two medications into one pill for convenience

•Can lower the risk of death from heart attack or stroke in people with Type 2 diabetes and heart disease

•Only taken once a day in the morning with or without food

•Not likely to cause weight gain

Cons

•Not safe for use in people on dialysis

•Not approved for people with Type 1 diabetes

•Might cause you to urinate more often

•Might cause urinary tract infections or genital yeast infections

Pros and Const for SGLT2 inhibitor / Biguanide
Pros

•Combines two medications into one pill

•Available as an extended-release tablet that lasts throughout the day (Invokamet XR)

•Can lower A1C (a blood test that measures your average sugar level over time) by up to 1.8% in people who aren't already taking either Invokana (canagliflozin) or metformin

•Dose can be adjusted based on how well the medication is working for you

Cons

•Might cause more urination

•Can lower vitamin B12 levels

•Raises the risk of urinary tract infections (UTIs), genital infections, and bone fractures

•Only available as brand
Common Side Effects of Glyxambi vs. Invokamet
Common Side Effects for

•Urinary tract infection (11-13%)

•Upper respiratory tract infection (7%)

Common Side Effects for

•Vaginal yeast infection in females (11-12%)

•Urinary tract infections (UTIs; 4-6%)

•More urination (5%)

•Male genital yeast or fungal infections (4%)

•Diarrhea (4%)
Warnings of Glyxambi vs. Invokamet
Common Side Effects for

•Pancreas problems

•Ketoacidosis (too much acid in the blood)

•Low fluids in the body (leading to low blood pressure or dehydration, or kidney problems)

•Low blood sugar with other diabetes medications

•Genital and urinary tract infections

•Serious allergic or skin reactions

•Joint pain

•Leg and foot amputations

•Heart failure

Common Side Effects for

•Lactic acidosis

•Leg and foot amputations

•Ketoacidosis

•Low fluids in the body (leading to low blood pressure or dehydration)

•Genital and urinary tract infections

•Low blood sugar (hypoglycemia) when used with certain other diabetes medications

•Severe allergic reactions

•Bone fractures

•Low vitamin B12 levels
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Compare Glyxambi vs. Invokamet

Key takeaways

Summary of Glyxambi vs. Invokamet

Indications of Glyxambi vs. Invokamet

Pros and Cons of Glyxambi vs. Invokamet

Common Side Effects of Glyxambi vs. Invokamet

Warnings of Glyxambi vs. Invokamet

Prices with our coupons for Glyxambi vs. Invokamet

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