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Compare Januvia vs. Rybelsus

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Januvia (sitagliptin)
    Rybelsus (semaglutide)
  • Januvia (sitagliptin)
    Rybelsus (semaglutide)

  • Summary of Januvia vs. Rybelsus

    Summary for DDP-4 inhibitor
    Prescription only

    Januvia (sitagliptin) is a prescription medication used along with a healthy diet and exercise to treat Type 2 diabetes. It belongs to the drug class dipeptidyl peptidase-4 (DPP-4) inhibitor, also known as gliptins. Januvia (sitagliptin) is taken by mouth, typically once daily. Most people don't experience many side effects from this medication, but possible ones include stuffy or runny nose, sore throat, and headache.

    Summary for GLP-1 agonist
    Prescription only

    Rybelsus (semaglutide) is a brand name glucagon-like peptide-1 (GLP-1) agonist that helps lower blood sugar in adults with Type 2 diabetes. Unlike other medications in this class, it's the first one available as a tablet you take by mouth. The pill is typically taken once a day, at least 30 minutes before you eat, drink, or take any other medications by mouth. It’s used along with diet and exercise, and might also help with weight loss. Common side effects include nausea, stomach pain, and diarrhea.

  • Indications of Januvia vs. Rybelsus

    Indications for
    •Type 2 diabetes in adults
    Indications for
    •Type 2 diabetes

  • Pros and Cons of Januvia vs. Rybelsus

    Pros and Const for DDP-4 inhibitor
    Pros
    •Only taken once a day
    •Can take with or without food
    •Not known to affect your body weight
    Cons
    •Can cause severe joint pain
    •Not a first choice option for people with Type 2 diabetes and heart problems
    •Might cause sudden kidney injury in people with kidney problems
    Pros and Const for GLP-1 agonist
    Pros
    •Only needs to be taken once per day
    •First GLP-1 agonist in pill form
    •Helps lower blood sugar and might also support weight loss
    Cons
    •Must be taken on an empty stomach
    •Stomach side effects like nausea, diarrhea, and stomach pain are common
    •Can't be used for Type 1 diabetes

  • Common Side Effects of Januvia vs. Rybelsus

    Common Side Effects for
    •Runny nose, sore throat, and other symptoms of the common cold (5%)
    Common Side Effects for
    •Nausea (11-20%)
    •Stomach pain (10-11%)
    •Diarrhea (9-10%)
    •Lower appetite (6-9%)
    •Vomiting (6-8%)
    •Constipation (5-6%)

  • Warnings of Januvia vs. Rybelsus

    Common Side Effects for
    •Pancreas problems
    •Heart failure
    •Sudden kidney problems
    •Serious allergic reactions
    •Joint pain
    •Severe skin reactions
    Common Side Effects for
    •Risk of thyroid tumors
    •Inflammation of the pancreas (pancreatitis)
    •Eye problems
    •Low blood sugar (hypoglycemia) when taken with certain diabetes medications
    •Kidney damage
    •Severe stomach side effects
    •Severe allergic reactions
    •Gallbladder problems
    •Lung problems during anesthesia or deep sedation

  • Prices with our coupons for Januvia vs. Rybelsus

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    Learn more about Rybelsus

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