Key takeaways
Toujeo (insulin glargine) and Januvia (sitagliptin) are both used to manage diabetes, but they have some key differences. Toujeo is a long-acting insulin used for both Type 1 and Type 2 diabetes. It's injected under the skin once daily. Toujeo helps your body absorb sugar from the bloodstream and store it for energy. On the other hand, Januvia is a DPP-4 inhibitor taken orally once a day, and is only used for Type 2 diabetes. Januvia works by blocking a protein that breaks down hormones, allowing insulin to stay in your body longer and reducing sugar production. While Toujeo can cause low blood sugar and weight gain, Januvia is not known to affect body weight but can cause severe joint pain and kidney problems. Additionally, Toujeo is available only as a brand-name medication, whereas Januvia also has a combination form with metformin called Janumet.
