Gliptins (also called dipeptidyl peptidase-4, or DPP-4, inhibitors) are used to treat Type 2 diabetes. They work by blocking the enzyme dipeptidyl peptidase-4 (DPP-4), which helps increase natural insulin release and decrease the amount of glucose (sugar) your liver makes. These medications are available as oral tablets. Examples include sitagliptin (Januvia), saxagliptin (Onglyza), and linagliptin (Tradjenta). You can discuss with your healthcare team which option might be right for you.