Skip to main content
HomeDrug Comparisons
Drug bottle and Pill

Compare Januvia vs. Ozempic

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Januvia (sitagliptin) and Ozempic (semaglutide) are both medications used to treat Type 2 diabetes, but they belong to different drug classes. Januvia is a dipeptidyl peptidase-4 (DPP-4) inhibitor, while Ozempic is a glucagon-like peptide-1 (GLP-1) receptor agonist. Januvia is taken orally once a day, whereas Ozempic is injected under the skin once a week. Januvia is available in a generic form, but Ozempic only available as a brand-name medication. Common side effects of Januvia include a runny nose and headache, while Ozempic often causes nausea, vomiting, and diarrhea. Both medications can cause low blood sugar when taken with other diabetes medications. Ozempic also has additional FDA-approved indications for lowering the risk of heart attack, stroke, and death in adults with Type 2 diabetes and heart disease, while Januvia does not.

  • Januvia (sitagliptin)
    Ozempic (semaglutide)
  • Januvia (sitagliptin)
    Ozempic (semaglutide)

  • Summary of Januvia vs. Ozempic

    Summary for DDP-4 inhibitor
    Prescription only

    Januvia (sitagliptin) is a prescription medication that helps lower blood sugar in adults with Type 2 diabetes. It works best when you also follow a balanced diet and exercise regularly. It belongs to the drug class called dipeptidyl peptidase-4 (DPP-4) inhibitors, or gliptins. Januvia (sitagliptin) comes as a tablet you take by mouth once a day. Side effects include stuffy or runny nose and headache. Januvia (sitagliptin) is a brand-name medication only; the generic version isn't available yet.

    Summary for GLP-1 agonist
    Prescription only

    Ozempic (semaglutide) is a prescription injection used with diet and exercise to help manage Type 2 diabetes in adults. It's also FDA approved to lower the risk of heart attack, stroke, and heart-related death in those with Type 2 diabetes and heart disease. In addition, it can reduce the risk of worsening kidney problems in people with Type 2 diabetes and chronic kidney disease (CKD). Ozempic (semaglutide) is a GLP-1 agonist that's injected under the skin once a week. Common side effects include nausea, vomiting, and diarrhea.

  • Indications of Januvia vs. Ozempic

    Indications for
    •Type 2 diabetes in adults
    Indications for
    •Type 2 diabetes
    •Lower the risk of heart attack, stroke, and heart-related death in adults with Type 2 diabetes and heart disease
    •Lower the risk of worsening kidney problems and heart-related death in adults with Type 2 diabetes and chronic kidney disease (CKD)

  • Pros and Cons of Januvia vs. Ozempic

    Pros and Const for DDP-4 inhibitor
    Pros
    •Taken once a day
    •Not likely to affect your body weight
    Cons
    •Not for people with Type 1 diabetes
    •Possible risk of severe joint pain
    Pros and Const for GLP-1 agonist
    Pros
    •Only given once per week
    •Might help you lose weight
    •Helps lower the risk of heart problems and kidney problems in people with type 2 diabetes
    •Can store open and used pens at room temperature for up to 8 weeks
    Cons
    •Is an injection given under the skin
    •Commonly causes nausea, vomiting, and diarrhea
    •Risk of low blood sugar if taken with certain diabetes medications
    •Can't be used for Type 1 diabetes

  • Common Side Effects of Januvia vs. Ozempic

    Common Side Effects for
    •Runny or stuffy nose and other symptoms of the common cold (5%)
    Common Side Effects for
    •Nausea (16-20%)
    •Diarrhea (9%)
    •Vomiting (5-9%)
    •Stomach pain (6-7%)
    •Constipation (3-5%)

  • Warnings of Januvia vs. Ozempic

    Common Side Effects for
    •Inflammation of the pancreas (pancreatitis)
    •Risk of heart failure
    •Sudden kidney problems
    •Low blood sugar when taken with other diabetes medications
    •Serious allergic reactions
    •Joint pain
    •Severe skin reactions
    Common Side Effects for
    •Risk of thyroid tumors
    •Inflammation of the pancreas (pancreatitis)
    •Eye problems
    •Low blood sugar (hypoglycemia) when taken with certain diabetes medications
    •Kidney damage
    •Severe stomach problems
    •Severe allergic reactions
    •Gallbladder problems
    •Lung problems during anesthesia or deep sedation

  • Prices with our coupons for Januvia vs. Ozempic

    Learn more about Januvia
    Learn more about Ozempic

Compare other Diabetes Type 2 drugs

Alogliptin vs JanuviaGlyxambi vs JanuviaJanuvia vs ActosJanuvia vs AfrezzaJanuvia vs AmarylJanuvia vs ByettaJanuvia vs FarxigaJanuvia vs GlipizideJanuvia vs GlucotrolJanuvia vs GlucovanceJanuvia vs InvokanaJanuvia vs JanumetJanuvia vs JardianceJanuvia vs OnglyzaJanuvia vs OzempicJanuvia vs RybelsusJanuvia vs StarlixJanuvia vs TradjentaJanuvia vs VictozaJanuvia vs ZituvioMetaglip vs JanuviaMetformin vs JanuviaNesina vs JanuviaSaxagliptin vs JanuviaToujeo vs JanuviaTrulicity vs JanuviaMetaglip vs NesinaNesina vs ActosNesina vs AfrezzaNesina vs Byetta
View More

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.