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Compare Januvia vs. Glipizide

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Januvia (sitagliptin)
    Glipizide
  • Januvia (sitagliptin)
    Glipizide

  • Summary of Januvia vs. Glipizide

    Summary for DDP-4 inhibitor
    Prescription only

    Januvia (sitagliptin) is a prescription medication used along with a healthy diet and exercise to treat Type 2 diabetes. It belongs to the drug class dipeptidyl peptidase-4 (DPP-4) inhibitor, also known as gliptins. Januvia (sitagliptin) is taken by mouth, typically once daily. Most people don't experience many side effects from this medication, but possible ones include stuffy or runny nose, sore throat, and headache.

    Summary for Sulfonylurea
    Prescription only

    Glipizide is a sulfonylurea medication used to treat Type 2 diabetes in adults. It lowers blood sugar levels by telling your pancreas to release more insulin. Glipizide is taken by mouth, typically once or twice daily. Some side effects of this medication include dizziness and diarrhea. Taking glipizide can also put you at risk for dangerously low blood sugar, so it's important to take this medication with meals.

  • Indications of Januvia vs. Glipizide

    Indications for
    •Type 2 diabetes in adults
    Indications for
    •Type 2 diabetes

  • Pros and Cons of Januvia vs. Glipizide

    Pros and Const for DDP-4 inhibitor
    Pros
    •Only taken once a day
    •Can take with or without food
    •Not known to affect your body weight
    Cons
    •Can cause severe joint pain
    •Not a first choice option for people with Type 2 diabetes and heart problems
    •Might cause sudden kidney injury in people with kidney problems
    Pros and Const for Sulfonylurea
    Pros
    •Taken by mouth
    •Extended-release tablets taken once daily
    •Available as a lower-cost generic medication
    Cons
    •Raises your risk for low blood sugar levels (hypoglycemia)
    •Need to take with meals or 30 minutes before a meal
    •Can cause some weight gain as a side effect

  • Common Side Effects of Januvia vs. Glipizide

    Common Side Effects for
    •Runny nose, sore throat, and other symptoms of the common cold (5%)
    Common Side Effects for
    •Dizziness (7%)
    •Diarrhea (5%)
    •Nervousness (4%)
    •Tremor (4%)
    •Passing gas (3%)
    •Low blood sugar levels (3%)

    Note: Side effects were reported by people who took glipizide ER (Glucotrol XL) in clinical studies.

  • Warnings of Januvia vs. Glipizide

    Common Side Effects for
    •Pancreas problems
    •Heart failure
    •Sudden kidney problems
    •Serious allergic reactions
    •Joint pain
    •Severe skin reactions
    Common Side Effects for
    •Low blood sugar levels
    •Risk of low red blood cell count (hemolytic anemia)
    •Possible risk of serious heart problems
    •Risk of harm in people with certain stomach problems (extended-release tablets)

  • Prices with our coupons for Januvia vs. Glipizide

    Learn more about Januvia
    Learn more about Glipizide

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