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Compare Alogliptin vs. Januvia

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Alogliptin (Nesina) and sitagliptin (Januvia) are both medications used to treat Type 2 diabetes and belong to the same drug class, dipeptidyl peptidase-4 (DPP-4) inhibitors. They help lower blood sugar levels by increasing insulin release and lowering the amount of sugar your body makes. However, there are some differences between the two medications. Alogliptin is typically taken at a dose of 6.25 mg to 25 mg once daily, while sitagliptin is taken at a dose of 25 mg to 100 mg once daily. Alogliptin is available as a lower-cost generic, but sitagliptin is only available as a brand name medication. Alogliptin may cause side effects like headaches and symptoms of the common cold, while sitagliptin can cause a runny nose and sore throat. Both medications can cause joint pain and have risks related to heart failure and pancreatitis.

  • Alogliptin (Nesina)
    Januvia (sitagliptin)
  • Alogliptin (Nesina)
    Januvia (sitagliptin)

  • Summary of Alogliptin vs. Januvia

    Summary for DDP-4 inhibitor
    Prescription only

    Alogliptin (Nesina) is a medication that treats Type 2 diabetes. It's added to diet and exercise to help lower your blood sugar levels. But it isn't a first-choice treatment for this condition. Alogliptin (Nesina) is typically taken by mouth once a day. Some people may experience certain side effects, such as headaches or symptoms of the common cold (e.g., sore throat or runny nose), after starting this medication.

    Summary for DDP-4 inhibitor
    Prescription only

    Januvia (sitagliptin) is a prescription medication that helps lower blood sugar in adults with Type 2 diabetes. It works best when you also follow a balanced diet and exercise regularly. It belongs to the drug class called dipeptidyl peptidase-4 (DPP-4) inhibitors, or gliptins. Januvia (sitagliptin) comes as a tablet you take by mouth once a day. Side effects include stuffy or runny nose and headache. Januvia (sitagliptin) is a brand-name medication only; the generic version isn't available yet.

  • Indications of Alogliptin vs. Januvia

    Indications for
    •Type 2 diabetes
    Indications for
    •Type 2 diabetes in adults

  • Pros and Cons of Alogliptin vs. Januvia

    Pros and Const for DDP-4 inhibitor
    Pros
    •Taken once daily by mouth
    •Can be taken with or without food
    •Is available as a lower-cost generic
    Cons
    •Dose may change if you have kidney problems, while other similar medications, like Tradjenta (linagliptin), don't need dose changes
    •Not a first-choice treatment for Type 2 diabetes
    •Isn’t approved for Type 1 diabetes
    Pros and Const for DDP-4 inhibitor
    Pros
    •Taken once a day
    •Not likely to affect your body weight
    Cons
    •Not for people with Type 1 diabetes
    •Possible risk of severe joint pain

  • Common Side Effects of Alogliptin vs. Januvia

    Common Side Effects for
    •Upper respiratory tract infection (5%)
    •Common cold (5%)
    •Headache (4%)
    Common Side Effects for
    •Runny or stuffy nose and other symptoms of the common cold (5%)

  • Warnings of Alogliptin vs. Januvia

    Common Side Effects for
    •Heart failure
    •Severe joint pain
    •Inflammation of the pancreas
    •Liver problems
    •Severe itching rash
    Common Side Effects for
    •Inflammation of the pancreas (pancreatitis)
    •Risk of heart failure
    •Sudden kidney problems
    •Low blood sugar when taken with other diabetes medications
    •Serious allergic reactions
    •Joint pain
    •Severe skin reactions

  • Prices with our coupons for Alogliptin vs. Januvia

    Learn more about Alogliptin
    Learn more about Januvia

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