Skip to main content
HomeDrug Comparisons
Drug bottle and Pill

Compare Invokamet vs. Onglyza

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Invokamet (canagliflozin / metformin) and saxagliptin are both medications used to treat Type 2 diabetes. However, they belong to different medication classes. Invokamet is a combination of a sodium-glucose cotransporter 2 (SGLT2) inhibitor and a biguanide, while saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. Invokamet is available as immediate-release tablets taken twice daily or extended-release tablets taken once daily, whereas saxagliptin is taken once daily. Invokamet is only available as a brand-name medication, while saxagliptin is available in a generic form and used to be available as brand-name Onglyza. Invokamet can cause side effects like urinary tract infections, yeast infections, and frequent urination, while saxagliptin may lead to upper respiratory infections and headaches. Both medications can interact with other diabetes medications, potentially causing low blood sugar.

  • Invokamet (canagliflozin / metformin)
    Saxagliptin (Onglyza)
  • Invokamet (canagliflozin / metformin)
    Saxagliptin (Onglyza)

  • Summary of Invokamet vs. Onglyza

    Summary for SGLT2 inhibitor / Biguanide
    Prescription only

    Invokamet (canagliflozin / metformin) is a combination medication used along with diet and exercise to lower blood sugar levels in adults with Type 2 diabetes. It's available as immediate-release tablets that are taken twice daily, as well as extended-release tablets that are taken once daily. This medication raises the risk of urinary tract infections (UTIs) and genital infections.

    Summary for DPP-4 inhibitor
    Prescription only

    Saxagliptin (Onglyza) is an add-on medication to exercise and a balanced, nutritious diet to improve blood sugar control in adults with Type 2 diabetes. It belongs to the drug class called dipeptidyl peptidase-4 (DPP-4) inhibitors. The saxagliptin (Onglyza) dosage is taken by mouth once daily. Possible side effects include certain infections and headaches. The brand name, Onglyza, is no longer available. But the lower-cost generic version is still available.

  • Indications of Invokamet vs. Onglyza

    Indications for
    •Type 2 diabetes
    •To lower the risk of major heart events (e.g., heart attack, stroke) in adults with Type 2 diabetes and heart disease
    •To lower the risk of hospitalization for heart failure, death due to heart problems, and worsening of kidney problems in certain adults with Type 2 diabetes and diabetic kidney disease
    Indications for
    •Type 2 diabetes in adults

  • Pros and Cons of Invokamet vs. Onglyza

    Pros and Const for SGLT2 inhibitor / Biguanide
    Pros
    •Combines two medications into one pill
    •Available as an extended-release tablet that lasts throughout the day (Invokamet XR)
    •Can lower A1C (a blood test that measures your average sugar level over time) by up to 1.8% in people who aren't already taking either Invokana (canagliflozin) or metformin
    •Dose can be adjusted based on how well the medication is working for you
    Cons
    •Might cause more urination
    •Can lower vitamin B12 levels
    •Raises the risk of urinary tract infections (UTIs), genital infections, and bone fractures
    •Only available as brand
    Pros and Const for DPP-4 inhibitor
    Pros
    •Taken once daily (with or without food)
    •Less likely to cause weight gain (compared to some other diabetes medications)
    •Very low risk of causing hypoglycemia (low blood sugar) when it's taken by itself
    Cons
    •Doesn't lower A1C and blood sugar levels as well as other diabetes medications
    •Might raise risk of hospitalization due to heart failure in certain people
    •Not for treating Type 1 diabetes or diabetic ketoacidosis

  • Common Side Effects of Invokamet vs. Onglyza

    Common Side Effects for
    •Vaginal yeast infection in females (11-12%)
    •Urinary tract infections (UTIs; 4-6%)
    •More urination (5%)
    •Male genital yeast or fungal infections (4%)
    •Diarrhea (4%)
    Common Side Effects for
    •Upper respiratory tract infection (8%)
    •Urinary tract infection (UTI; 7%)
    •Headache (7%)

  • Warnings of Invokamet vs. Onglyza

    Common Side Effects for
    •Lactic acidosis
    •Leg and foot amputations
    •Ketoacidosis
    •Low fluids in the body (leading to low blood pressure or dehydration)
    •Genital and urinary tract infections
    •Low blood sugar (hypoglycemia) when used with certain other diabetes medications
    •Severe allergic reactions
    •Bone fractures
    •Low vitamin B12 levels
    Common Side Effects for
    •Pancreas problems
    •Heart failure
    •Low blood sugar (hypoglycemia)
    •Joint pain
    •Large blisters
    •Risk of allergic reaction

  • Prices with our coupons for Invokamet vs. Onglyza

    Learn more about Invokamet
    Learn more about Saxagliptin

Compare other Diabetes Type 2 drugs

Glyxambi vs InvokametInvokamet vs ActosInvokamet vs GlucovanceInvokamet vs MetaglipInvokamet vs OnglyzaInvokamet vs PrecoseInvokana vs InvokametJardiance vs InvokametTradjenta vs InvokametGlucotrol vs GlucovanceGlucovance vs GlyburideGlucovance vs GlyxambiGlucovance vs HumalogGlucovance vs Human InsulinGlucovance vs JardianceGlucovance vs LantusGlucovance vs LevemirGlucovance vs NovologGlucovance vs OnglyzaGlyxambi vs MetaglipInvokana vs GlucovanceInvokana vs MetaglipJanuvia vs GlucovanceJardiance vs MetaglipMetaglip vs ActosMetaglip vs AfrezzaMetaglip vs ByettaMetaglip vs GlyburideMetformin vs GlucovancePrecose vs Glucovance
View More

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.