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Compare Invokana vs. Invokamet

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Invokana (canagliflozin) and Invokamet (canagliflozin/metformin) are both used to treat Type 2 diabetes, but they have some key differences. Invokana contains only canagliflozin, which works by helping your kidneys remove excess sugar through urine and can also improve heart and kidney health. On the other hand, Invokamet combines canagliflozin with metformin, a biguanide, and is available in both immediate-release (taken twice daily) and extended-release (taken once daily) forms, combining two medications into one pill, potentially simplifying your treatment regimen. Metformin helps lower the amount of sugar your liver makes and improves your body's response to insulin. While both medications can cause side effects like urinary tract infections and genital infections, Invokamet also carries a risk of low vitamin B12 levels and lactic acidosis due to the metformin component. Both are only available as brand-name medications.

  • Invokana (canagliflozin)
    Invokamet (canagliflozin / metformin)
  • Invokana (canagliflozin)
    Invokamet (canagliflozin / metformin)

  • Summary of Invokana vs. Invokamet

    Summary for SGLT2 inhibitor
    Prescription only

    Invokana (canagliflozin) is a medication that's used together with a healthy diet and exercise to lower blood sugar levels in adults with Type 2 diabetes. It can also lessen the chance of worsening heart and kidney problems in some people with Type 2 diabetes. This medication is taken by mouth once a day.

    Summary for SGLT2 inhibitor / Biguanide
    Prescription only

    Invokamet (canagliflozin / metformin) is a combination medication used along with diet and exercise to lower blood sugar levels in adults with Type 2 diabetes. It's available as immediate-release tablets that are taken twice daily, as well as extended-release tablets that are taken once daily. This medication raises the risk of urinary tract infections (UTIs) and genital infections.

  • Indications of Invokana vs. Invokamet

    Indications for
    •Type 2 diabetes
    •Lowering the risk of major heart events (e.g., heart attack, stroke) in adults with Type 2 diabetes and heart disease
    •Lowering the risk of hospitalization for heart failure, death due to heart problems, and worsening of kidney problems in certain adults with Type 2 diabetes and diabetic kidney disease
    Indications for
    •Type 2 diabetes
    •To lower the risk of major heart events (e.g., heart attack, stroke) in adults with Type 2 diabetes and heart disease
    •To lower the risk of hospitalization for heart failure, death due to heart problems, and worsening of kidney problems in certain adults with Type 2 diabetes and diabetic kidney disease

  • Pros and Cons of Invokana vs. Invokamet

    Pros and Const for SGLT2 inhibitor
    Pros
    •Only taken once a day
    •Can use alone or together with other diabetes medications
    •Dose can be adjusted based on how well the medication is working for you
    Cons
    •Only available as brand only
    •Might raise the risk of genital infections or bone fracture
    •Not recommended in second and third trimesters of pregnancy
    •Unknown if safe or works well in people on dialysis
    Pros and Const for SGLT2 inhibitor / Biguanide
    Pros
    •Combines two medications into one pill
    •Available as an extended-release tablet that lasts throughout the day (Invokamet XR)
    •Can lower A1C (a blood test that measures your average sugar level over time) by up to 1.8% in people who aren't already taking either Invokana (canagliflozin) or metformin
    •Dose can be adjusted based on how well the medication is working for you
    Cons
    •Might cause more urination
    •Can lower vitamin B12 levels
    •Raises the risk of urinary tract infections (UTIs), genital infections, and bone fractures
    •Only available as brand

  • Common Side Effects of Invokana vs. Invokamet

    Common Side Effects for
    •Vaginal yeast infection in females (11-12%)
    •Urinary tract infections (UTIs; 4-6%)
    •More urination (5%)
    Common Side Effects for
    •Vaginal yeast infection in females (11-12%)
    •Urinary tract infections (UTIs; 4-6%)
    •More urination (5%)
    •Male genital yeast or fungal infections (4%)
    •Diarrhea (4%)

  • Warnings of Invokana vs. Invokamet

    Common Side Effects for
    •Leg and foot amputations
    •Ketoacidosis
    •Low fluids in the body (leading to low blood pressure or dehydration)
    •Genital and urinary tract infections
    •Low blood sugar (hypoglycemia) when used with certain other diabetes medications
    •Severe allergic reactions
    •Bone fractures
    Common Side Effects for
    •Lactic acidosis
    •Leg and foot amputations
    •Ketoacidosis
    •Low fluids in the body (leading to low blood pressure or dehydration)
    •Genital and urinary tract infections
    •Low blood sugar (hypoglycemia) when used with certain other diabetes medications
    •Severe allergic reactions
    •Bone fractures
    •Low vitamin B12 levels

  • Prices with our coupons for Invokana vs. Invokamet

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