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Compare Entresto vs. Jardiance

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Entresto (sacubitril / valsartan) and Jardiance (empagliflozin) are both medications that can help with heart-related conditions, but they belong to different medication classes and have different uses. Entresto is an angiotensin receptor-neprilysin inhibitor (ARNI) used to treat heart failure in people ages 1 year and older. Jardiance, on the other hand, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used to manage Type 2 diabetes in people aged 10 and older, and it also helps lower the risk of heart problems in adults with heart failure or chronic kidney disease. Entresto is taken twice a day, while Jardiance is taken once daily. Entresto is available as tablets or oral pellets, and it doesn't have a generic version. Jardiance is only available as a tablet and also lacks a generic version. Common side effects of Entresto include low blood pressure, high potassium levels, and dizziness, while Jardiance can cause urinary tract infections, yeast infections, and increased urination. Entresto should not be taken with angiotensin II receptor blockers (ARBs) or angiotensin-converting enzyme (ACE) inhibitors due to risks of increased side effects. Jardiance can cause low blood sugar when combined with other diabetes medications.

Entresto (sacubitril / valsartan)
Jardiance (empagliflozin)
Entresto (sacubitril / valsartan)
Jardiance (empagliflozin)
Summary of Entresto vs. Jardiance
Summary for Angiotensin receptor-neprilysin inhibitor (ARNI)
Prescription only
Entresto (sacubitril / valsartan) is a combination medication called an angiotensin receptor-neprilysin inhibitor (ARNI). It's used for heart failure in adults and children ages 1 year and older. It helps lower the risk of hospital stays and heart-related death in adults with heart failure. You usually take the medication by mouth twice a day. Entresto is available as tablets. It also comes as Entresto Sprinkle, which are capsules you open and mix the pellets inside with soft food. Side effects include low blood pressure and cough. As of early 2025, there's no generic version of this medication.
Summary for SGLT2 inhibitor
Prescription only
Jardiance (empagliflozin) is a brand-name medication that's used along with a nutritious diet and routine exercise to improve blood sugar levels in people 10 years and older with Type 2 diabetes. It can also lower the chance of serious complications, hospitalization, and death in certain adults with heart failure or chronic kidney disease (CKD). Jardiance (empagliflozin) belongs to the drug class called sodium-glucose cotransporter 2 (SGLT2) inhibitors. It's a tablet that's taken by mouth once a day. Side effects can include urinary tract infections (UTIs), yeast infections, and weight loss.
Indications of Entresto vs. Jardiance
Indications for

•Heart failure in people ages 1 year or older

Indications for

•Type 2 diabetes (in addition to diet and exercise) in people age 10 years and older

•Lowering the risk of death due to heart problems in adults with Type 2 diabetes and heart disease

•Lowering the risk of hospitalization and death due to heart problems in adults with heart failure

•Lowering the risk of worsening kidney problems, hospitalization, and death due to heart problems in adults with chronic kidney disease (CKD)
Pros and Cons of Entresto vs. Jardiance
Pros and Const for Angiotensin receptor-neprilysin inhibitor (ARNI)
Pros

•First-choice treatment for some people with heart failure

•Can lower the risk of hospital visits related to heart failure in adults

•Combines two medications into one pill for convenience

•Available as tablets, oral pellets, or a prepared oral solution

Cons

•Need to take twice daily

•Can cause dizziness and low blood pressure

•Not safe during pregnancy

Pros and Const for SGLT2 inhibitor
Pros

•Taken by mouth once a day

•Unlikely to cause weight gain

•Can take with other diabetes medications

Cons

•Raises risk of urinary tract infections (UTIs) and genital yeast infections

•Might make you urinate more

•Not recommended during the second and third trimesters of pregnancy
Common Side Effects of Entresto vs. Jardiance
Common Side Effects for

•Low blood pressure (18%)

•High potassium levels (12%)

•Cough (9%)

•Dizziness (6%)

•Kidney problems (5%)

Common Side Effects for

•Urinary tract infection (UTI; 8-9%)

•Vaginal yeast infection in females (5-6%)

•Upper respiratory tract infection (3-4%)

•High cholesterol or fat levels (3-4%)

•Urinating more than usual (3%)
Warnings of Entresto vs. Jardiance
Common Side Effects for

•Not safe during pregnancy

•Swelling of face, tongue, or throat (angioedema)

•Low blood pressure

•Kidney problems

•High potassium levels

Common Side Effects for

•Ketoacidosis

•Low fluids in the body (leading to low blood pressure or dehydration)

•Genital and urinary tract infections

•Low blood sugar (hypoglycemia) when used with certain other diabetes medications

•Leg and foot amputations

•Allergic reactions
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Compare Entresto vs. Jardiance

Key takeaways

Summary of Entresto vs. Jardiance

Indications of Entresto vs. Jardiance

Pros and Cons of Entresto vs. Jardiance

Common Side Effects of Entresto vs. Jardiance

Warnings of Entresto vs. Jardiance

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