Skip to main content
HomeDrug Comparisons
Drug bottle and Pill

Compare Entresto vs. Jardiance

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Entresto (sacubitril / valsartan)
    Jardiance (empagliflozin)
  • Entresto (sacubitril / valsartan)
    Jardiance (empagliflozin)

  • Summary of Entresto vs. Jardiance

    Summary for Angiotensin receptor-neprilysin inhibitor (ARNI)
    Prescription only

    Entresto (sacubitril / valsartan) is a combination medication called an angiotensin receptor-neprilysin inhibitor (ARNI). It's used for heart failure in adults and children ages 1 year and older. It helps lower the risk of hospital stays and heart-related death in adults with heart failure. You usually take the medication by mouth twice a day. Entresto is available as tablets. It also comes as Entresto Sprinkle, which are capsules you open and mix the pellets inside with soft food. Side effects include low blood pressure and cough. As of early 2025, there's no generic version of this medication.

    Summary for SGLT2 inhibitor
    Prescription only

    Jardiance (empagliflozin) is a brand-name medication that's used along with a nutritious diet and routine exercise to improve blood sugar levels in people 10 years and older with Type 2 diabetes. It can also lower the chance of serious complications, hospitalization, and death in certain adults with heart failure or chronic kidney disease (CKD). Jardiance (empagliflozin) belongs to the drug class called sodium-glucose cotransporter 2 (SGLT2) inhibitors. It's a tablet that's taken by mouth once a day. Side effects can include urinary tract infections (UTIs), yeast infections, and weight loss.

  • Indications of Entresto vs. Jardiance

    Indications for
    •Heart failure in people ages 1 year or older
    Indications for
    •Type 2 diabetes (in addition to diet and exercise) in people age 10 years and older
    •Lowering the risk of death due to heart problems in adults with Type 2 diabetes and heart disease
    •Lowering the risk of hospitalization and death due to heart problems in adults with heart failure
    •Lowering the risk of worsening kidney problems, hospitalization, and death due to heart problems in adults with chronic kidney disease (CKD)

  • Pros and Cons of Entresto vs. Jardiance

    Pros and Const for Angiotensin receptor-neprilysin inhibitor (ARNI)
    Pros
    •First-choice treatment for some people with heart failure
    •Can lower the risk of hospital visits related to heart failure in adults
    •Combines two medications into one pill for convenience
    •Available as tablets, oral pellets, or a prepared oral solution
    Cons
    •Need to take twice daily
    •Can cause dizziness and low blood pressure
    •Not safe during pregnancy
    Pros and Const for SGLT2 inhibitor
    Pros
    •Taken by mouth once a day
    •Unlikely to cause weight gain
    •Can take with other diabetes medications
    Cons
    •Raises risk of urinary tract infections (UTIs) and genital yeast infections
    •Might make you urinate more
    •Not recommended during the second and third trimesters of pregnancy

  • Common Side Effects of Entresto vs. Jardiance

    Common Side Effects for
    •Low blood pressure (18%)
    •High potassium levels (12%)
    •Cough (9%)
    •Dizziness (6%)
    •Kidney problems (5%)
    Common Side Effects for
    •Urinary tract infection (UTI; 8-9%)
    •Vaginal yeast infection in females (5-6%)
    •Upper respiratory tract infection (3-4%)
    •High cholesterol or fat levels (3-4%)
    •Urinating more than usual (3%)

  • Warnings of Entresto vs. Jardiance

    Common Side Effects for
    •Not safe during pregnancy
    •Swelling of face, tongue, or throat (angioedema)
    •Low blood pressure
    •Kidney problems
    •High potassium levels
    Common Side Effects for
    •Ketoacidosis
    •Low fluids in the body (leading to low blood pressure or dehydration)
    •Genital and urinary tract infections
    •Low blood sugar (hypoglycemia) when used with certain other diabetes medications
    •Leg and foot amputations
    •Allergic reactions

  • Prices with our coupons for Entresto vs. Jardiance

    Learn more about Entresto
    Learn more about Jardiance

Compare other Heart Failure drugs

Entresto vs FarxigaEntresto vs JardianceEntresto vs LisinoprilEntresto vs LosartanEntresto vs RanexaEntresto vs ValsartanVasotec vs EntrestoVerquvo vs EntrestoBrenzavvy vs JardianceFarxiga vs JardianceGlucovance vs JardianceGlyxambi vs JardianceInpefa vs JardianceJanuvia vs JardianceJardiance vs ActosJardiance vs AfrezzaJardiance vs GlimepirideJardiance vs GlipizideJardiance vs GlucotrolJardiance vs GlyburideJardiance vs InvokametJardiance vs InvokanaJardiance vs JanumetJardiance vs MetaglipJardiance vs MetforminJardiance vs MounjaroJardiance vs OnglyzaJardiance vs OzempicJardiance vs PrecoseJardiance vs Synjardy
View More

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.