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Compare Entresto vs. Lisinopril

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Entresto (sacubitril/valsartan) and lisinopril (Zestril) are both medications used to treat heart failure, but they belong to different drug classes. Entresto is an angiotensin receptor-neprilysin inhibitor (ARNI), while lisinopril is an angiotensin-converting enzyme (ACE) inhibitor. Entresto is specifically approved for heart failure in adults and children over 1 year old, whereas lisinopril is also approved for high blood pressure and to lower the risk of death after a heart attack. Entresto is taken twice daily as tablets or oral pellets, while lisinopril is typically taken once daily and comes as a tablet or liquid. Entresto only comes as a branded medication, while lisinopril is available as a lower-cost generic. Common side effects of Entresto include low blood pressure, high potassium levels, and dizziness, while lisinopril can cause dizziness, low blood pressure, and a dry cough. Both medications can interact with other drugs, so be sure your prescriber and pharmacist have a complete list of your medications.

  • Entresto (sacubitril / valsartan)
    Lisinopril (Zestril)
  • Entresto (sacubitril / valsartan)
    Lisinopril (Zestril)

  • Summary of Entresto vs. Lisinopril

    Summary for Angiotensin receptor-neprilysin inhibitor (ARNI)
    Prescription only

    Entresto (sacubitril / valsartan) is a combination medication called an angiotensin receptor-neprilysin inhibitor (ARNI). It's used for heart failure in adults and children ages 1 year and older. It helps lower the risk of hospital stays and heart-related death in adults with heart failure. You usually take the medication by mouth twice a day. Entresto is available as tablets. It also comes as Entresto Sprinkle, which are capsules you open and mix the pellets inside with soft food. Side effects include low blood pressure and cough. As of early 2025, there's no generic version of this medication.

    Summary for ACE inhibitor
    Prescription only

    Lisinopril (Zestril) is an angiotensin-converting enzyme (ACE) inhibitor that's a first-choice medication used for lowering blood pressure. It's also approved to treat symptoms of heart failure and also to lower the risk of death after a heart attack. Lisinopril (Zestril) is a tablet that's taken by mouth, typically once daily. It's also available as an oral solution. Some common side effects of this medication include cough, dizziness, and headache.

  • Indications of Entresto vs. Lisinopril

    Indications for
    •Heart failure in people ages 1 year or older
    Indications for
    •High blood pressure
    •Heart failure
    •Lower the risk for death after a heart attack

  • Pros and Cons of Entresto vs. Lisinopril

    Pros and Const for Angiotensin receptor-neprilysin inhibitor (ARNI)
    Pros
    •First-choice treatment for some people with heart failure
    •Can lower the risk of hospital visits related to heart failure in adults
    •Combines two medications into one pill for convenience
    •Available as tablets, oral pellets, or a prepared oral solution
    Cons
    •Need to take twice daily
    •Can cause dizziness and low blood pressure
    •Not safe during pregnancy
    Pros and Const for ACE inhibitor
    Pros
    •A first-choice blood pressure medication
    •Taken by mouth once per day
    •Can be taken by children as young as 6 years old for treatment of high blood pressure
    •Available as a liquid (Qbrelis), good option for people who've difficulty swallowing tablets
    Cons
    •More likely to cause a dry cough, compared to ARBs
    •Can't be taken during pregnancy or breastfeeding
    •Might not work as well for lowering high blood pressure in black people

  • Common Side Effects of Entresto vs. Lisinopril

    Common Side Effects for
    •Low blood pressure (18%)
    •High potassium levels (12%)
    •Cough (9%)
    •Dizziness (6%)
    •Kidney problems (5%)
    Common Side Effects for
    •Dizziness (up to 19%)
    •Low blood pressure (7-11%)
    •Higher creatinine levels (7-10%)
    •Headache (6%)

  • Warnings of Entresto vs. Lisinopril

    Common Side Effects for
    •Not safe during pregnancy
    •Swelling of face, tongue, or throat (angioedema)
    •Low blood pressure
    •Kidney problems
    •High potassium levels
    Common Side Effects for
    •Not for use during pregnancy
    •Angioedema (swelling)
    •Low blood pressure
    •Worsening kidney problems
    •Heart problems due to high potassium
    •Liver problems

  • Prices with our coupons for Entresto vs. Lisinopril

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    Learn more about Lisinopril

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