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Compare Vasotec vs. Entresto

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Enalapril (Vasotec) and Entresto (sacubitril/valsartan) are both used to treat heart conditions, but they have some key differences. Enalapril is an ACE inhibitor that helps relax blood vessels to lower blood pressure and treat heart failure. It is available in generic form and can be taken once or twice daily. Entresto, on the other hand, is a combination of two medications: sacubitril, a neprilysin inhibitor, and valsartan, an ARB. It is specifically used for heart failure and is taken twice daily. Unlike Enalapril, Entresto is not available as a generic. Both medications can cause side effects like dizziness and cough, as well as low blood pressure and high potassium levels. Additionally, you should not take Entresto if you have taken an ACE inhibitor like Enalapril within the last 36 hours due to the risk of angioedema.

  • Enalapril (Vasotec)
    Entresto (sacubitril / valsartan)
  • Enalapril (Vasotec)
    Entresto (sacubitril / valsartan)

  • Summary of Vasotec vs. Entresto

    Summary for ACE inhibitor
    Prescription only

    Enalapril (Vasotec) is a first-choice medication used for treating high blood pressure. It's also approved for heart failure. Enalapril (Vasotec) belongs to a class of medications called angiotensin-converting enzyme (ACE) inhibitors. It's taken by mouth, once or twice daily. Enalapril (Vasotec) doesn't cause many side effects, but some include tiredness, dizziness, and cough.

    Summary for Angiotensin receptor-neprilysin inhibitor (ARNI)
    Prescription only

    Entresto (sacubitril / valsartan) is a combination medication called an angiotensin receptor-neprilysin inhibitor (ARNI). It's used for heart failure in adults and children ages 1 year and older. It helps lower the risk of hospital stays and heart-related death in adults with heart failure. You usually take the medication by mouth twice a day. Entresto is available as tablets. It also comes as Entresto Sprinkle, which are capsules you open and mix the pellets inside with soft food. Side effects include low blood pressure and cough. As of early 2025, there's no generic version of this medication.

  • Indications of Vasotec vs. Entresto

    Indications for
    •High blood pressure
    •Heart failure
    Indications for
    •Heart failure in people ages 1 year or older

  • Pros and Cons of Vasotec vs. Entresto

    Pros and Const for ACE inhibitor
    Pros
    •A first-choice blood pressure lowering medication for many people
    •Taken by mouth
    •Can be taken by children as young as 1 month old (high blood pressure only)
    •Available as a liquid for people who have trouble swallowing pills
    Cons
    •More likely to cause a dry cough, compared to angiotensin II receptor blockers (ARBs)
    •Can't be taken during pregnancy or breastfeeding
    •Might not work as well for lowering high blood pressure in black people
    •Need to take twice daily for heart failure
    Pros and Const for Angiotensin receptor-neprilysin inhibitor (ARNI)
    Pros
    •First-choice treatment for some people with heart failure
    •Can lower the risk of hospital visits related to heart failure in adults
    •Combines two medications into one pill for convenience
    •Available as tablets, oral pellets, or a prepared oral solution
    Cons
    •Need to take twice daily
    •Can cause dizziness and low blood pressure
    •Not safe during pregnancy

  • Common Side Effects of Vasotec vs. Entresto

    Common Side Effects for
    •Feeling tired (3%)
    Common Side Effects for
    •Low blood pressure (18%)
    •High potassium levels (12%)
    •Cough (9%)
    •Dizziness (6%)
    •Kidney problems (5%)

  • Warnings of Vasotec vs. Entresto

    Common Side Effects for
    •Not for use during pregnancy
    •Angioedema (swelling)
    •Low blood pressure
    •Worsening kidney problems
    •Heart problems due to high potassium
    •Liver problems
    Common Side Effects for
    •Not safe during pregnancy
    •Swelling of face, tongue, or throat (angioedema)
    •Low blood pressure
    •Kidney problems
    •High potassium levels

  • Prices with our coupons for Vasotec vs. Entresto

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