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Vasotec vs. Zestril

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Enalapril (Vasotec) and Lisinopril (Zestril) are both ACE inhibitors used to treat high blood pressure and heart failure. However, there are some key differences between them. Enalapril (Vasotec) can be used in children as young as 1 month old, while Lisinopril (Zestril) is only approved for children 6 years and older. Additionally, Lisinopril (Zestril) is also approved to lower the risk of death after a heart attack, which is not an approved use for Enalapril (Vasotec). Both medications can cause a dry cough, but this side effect can be managed by switching to a different type of medication if necessary. Enalapril (Vasotec) is typically taken once or twice daily, whereas Lisinopril (Zestril) is usually taken once daily. Both medications are available in generic forms, making them more affordable options.

Enalapril

(Vasotec)

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Lisinopril

(Zestril)

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Summary for Vasotec

Prescription only

Enalapril (Vasotec) is a first-choice medication used for treating high blood pressure. It's also approved for heart failure. Enalapril (Vasotec) belongs to a class of medications called angiotensin-converting enzyme (ACE) inhibitors. It's taken by mouth, once or twice daily. Enalapril (Vasotec) doesn't cause many side effects, but some include tiredness, dizziness, and cough.

Indications for Vasotec

  • High blood pressure
  • Heart failure

Pros and Cons for Vasotec

Pros

  • A first-choice blood pressure lowering medication for many people
  • Taken by mouth
  • Can be taken by children as young as 1 month old (high blood pressure only)
  • Available as a liquid for people who have trouble swallowing pills

Cons

Common Side Effects for Vasotec

  • Feeling tired (3%)

Warnings for Vasotec

  • Not for use during pregnancy
  • Angioedema (swelling)
  • Low blood pressure
  • Worsening kidney problems
  • Heart problems due to high potassium
  • Liver problems

Summary for Zestril

Prescription only

Lisinopril (Zestril) is an angiotensin-converting enzyme inhibitor, or ACE inhibitor. It's used to treat high blood pressure in people 6 years and older. In adults, it's also approved to manage heart failure and to lower the risk of death after a heart attack. Lisinopril (Zestril) comes as a tablet that's taken by mouth once daily. There's also an oral solution available under the brand name Qbrelis. Some side effects include dizziness, cough, and headache.

Indications for Zestril

Pros and Cons for Zestril

Pros

  • Taken by mouth once per day
  • A first-choice medication for high blood pressure
  • Also helpful for heart failure and after a heart attack
  • Okay for children as young as 6 years old to take to treat high blood pressure

Cons

Common Side Effects for Zestril

  • Dizziness (up to 19%)
  • Low blood pressure (up to 11%)
  • Higher creatinine levels (up to 10%)

Warnings for Zestril

  • Harm to an unborn baby
  • Angioedema (swelling)
  • Low blood pressure
  • Possible worsening of kidney problems
  • High potassium levels
  • Liver problems

Prices with our coupons for Vasotec vs. Zestril

Price Card Drug Icon
Enalapril60 tablets / 20mg
$17.20$53.10
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Price Card Drug Icon
Lisinopril30 tablets / 20mg
$7.79$13.68
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