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Compare Verquvo vs. Entresto

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Verquvo (vericiguat)
    Entresto (sacubitril / valsartan)
  • Verquvo (vericiguat)
    Entresto (sacubitril / valsartan)

  • Summary of Verquvo vs. Entresto

    Summary for sGC stimulator
    Prescription only

    Verquvo (vericiguat) is used in adults with chronic (long-lasting) heart failure to lower the risk of dying and lessen the need to go to the hospital for heart complications. Verquvo (vericiguat) is an option for people who still experience symptoms after being recently hospitalized for heart failure or needing to use injectable heart failure medications. It's only available as a brand medication and can be expensive.

    Summary for Angiotensin receptor-neprilysin inhibitor (ARNI)
    Prescription only

    Entresto (sacubitril / valsartan) is a combination medication called an angiotensin receptor-neprilysin inhibitor (ARNI). It's used for heart failure in adults and children ages 1 year and older. It helps lower the risk of hospital stays and heart-related death in adults with heart failure. You usually take the medication by mouth twice a day. Entresto is available as tablets. It also comes as Entresto Sprinkle, which are capsules you open and mix the pellets inside with soft food. Side effects include low blood pressure and cough. As of early 2025, there's no generic version of this medication.

  • Indications of Verquvo vs. Entresto

    Indications for
    •Chronic (long-lasting) heart failure
    Indications for
    •Heart failure in people ages 1 year or older

  • Pros and Cons of Verquvo vs. Entresto

    Pros and Const for sGC stimulator
    Pros
    •Helps you live longer with heart failure
    •Can lessen hospitalizations for heart failure
    •Can be crushed and mixed with water in people who have difficulty swallowing tablets
    •Taken once a day
    Cons
    •Brand only, so can be expensive
    •Not safe in pregnancy or breastfeeding
    •Can't be used in children
    Pros and Const for Angiotensin receptor-neprilysin inhibitor (ARNI)
    Pros
    •First-choice treatment for some people with heart failure
    •Can lower the risk of hospital visits related to heart failure in adults
    •Combines two medications into one pill for convenience
    •Available as tablets, oral pellets, or a prepared oral solution
    Cons
    •Need to take twice daily
    •Can cause dizziness and low blood pressure
    •Not safe during pregnancy

  • Common Side Effects of Verquvo vs. Entresto

    Common Side Effects for
    •Low blood pressure (16%)
    •Low red blood cell count (anemia, 10%)
    Common Side Effects for
    •Low blood pressure (18%)
    •High potassium levels (12%)
    •Cough (9%)
    •Dizziness (6%)
    •Kidney problems (5%)

  • Warnings of Verquvo vs. Entresto

    Common Side Effects for
    •Harm to unborn baby
    Common Side Effects for
    •Not safe during pregnancy
    •Swelling of face, tongue, or throat (angioedema)
    •Low blood pressure
    •Kidney problems
    •High potassium levels

  • Prices with our coupons for Verquvo vs. Entresto

    Learn more about Verquvo
    Learn more about Entresto

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