Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Ertugliflozin (Steglatro) and dapagliflozin (Farxiga) are both SGLT2 medications used to treat type 2 diabetes. They help lower blood sugar levels by preventing sugar from being reabsorbed into the body through the kidneys. However, they have some differences. Ertugliflozin is only available as a brand-name medication, while dapagliflozin is available as both a brand and a lower-cost generic. Dapagliflozin is also approved for additional uses, such as reducing the risk of hospitalization for heart failure in those with type 2 diabetes, while ertugliflozin is not. Both medications are taken once daily, but dapagliflozin can be used by people as young as 10 years old, whereas ertugliflozin is for adults only. Common side effects for both include yeast infections, increased urination, and urinary tract infections. Both medications can interact with other diabetes treatments, increasing the risk of low blood sugar.
Farxiga, the brand name for dapagliflozin, is used together with a nutritious diet and exercise plan to lower blood sugar levels in people 10 years and older with Type 2 diabetes. It can also help lower the risk of serious complications, hospitalization, and death in certain adults with heart failure or chronic kidney disease (CKD). Farxiga (dapagliflozin) belongs to the drug class called sodium-glucose cotransporter 2 (SGLT2) inhibitors. It's taken by mouth once a day. Some side effects include yeast infections, urinating more often, and weight loss.
•Type 2 diabetes (in addition to diet and exercise) in people age 10 and over
•Lowering the risk of hospitalization for heart failure in adults with Type 2 diabetes and heart disease
•Lowering the risk of hospitalization and death due to heart problems in people with heart failure
•Lowering the risk of worsening kidney problems, hospitalization for heart failure, and death due to heart problems in adults with chronic kidney disease (CKD)
Pros and Cons of Steglatro vs. Farxiga
Pros and Const for SGLT2 inhibitor
Pros
•Only need to take once a day
•Can take with or without meals
Cons
•Might raise the risk of yeast infections
•Not recommended for people with Type 1 diabetes or those with severe kidney problems
Pros and Const for SGLT2 inhibitor
Pros
•Taken only once daily
•Low risk of causing low blood sugar when taken by itself