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Jardiance vs. Glimepiride

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Empagliflozin (Jardiance) and glimepiride (Amaryl) are both medications used to treat Type 2 diabetes, but they belong to different drug classes. Empagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, while glimepiride is a sulfonylurea. Empagliflozin is also FDA-approved to lower the risk of heart and kidney problems in certain adults, whereas glimepiride is only approved for Type 2 diabetes. You take empagliflozin once daily in the morning, and glimepiride is taken once daily with your first main meal. Empagliflozin does not have a generic version available, but glimepiride is available as a lower-cost generic. Common side effects of empagliflozin include urinary tract infections, yeast infections, and frequent urination. Glimepiride can cause low blood sugar and weight gain as common side effects. Both medications can interact with alcohol and diabetes medications—leading to a higher risk of low blood sugar.

Jardiance

(empagliflozin)

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Glimepiride

(Amaryl)

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Summary for Jardiance

Prescription only

Jardiance (empagliflozin) is a medication that helps lower blood sugar for people 10 years and older with Type 2 diabetes. For the best results, it's used along with a nutritious diet and exercise. Jardiance (empagliflozin) can also help lower the risk of complications, hospital stays, and death for adults with heart failure or chronic kidney disease (CKD). This medication belongs to the drug class called sodium-glucose cotransporter 2 (SGLT2) inhibitors. It comes as a tablet that you take by mouth once a day. Side effects include urinary tract infections (UTIs) and yeast infections.

Indications for Jardiance

  • Type 2 diabetes (in addition to diet and exercise) in people age 10 years and older
  • Lowering the risk of death due to heart problems in adults with Type 2 diabetes and heart disease
  • Lowering the risk of hospital stays and death due to heart problems in adults with heart failure
  • Lowering the risk of worsening kidney problems, hospital stays, and death due to heart problems in adults with chronic kidney disease (CKD)

Pros and Cons for Jardiance

Pros

  • Taken by mouth once a day
  • Might notice some weight loss
  • Can take with other diabetes medications

Cons

Common Side Effects for Jardiance

Warnings for Jardiance

  • Ketoacidosis
  • Low fluids in the body (leading to low blood pressure or dehydration)
  • Genital and urinary tract infections
  • Low blood sugar (hypoglycemia) when used with certain other diabetes medications
  • Leg and foot amputations
  • Allergic reactions

Summary for Glimepiride

Prescription only

Glimepiride (Amaryl) is a medication used to treat type 2 diabetes along with healthy diet and exercise. It's part of the medication class called sulfonylureas. This medication is taken by mouth, typically once daily with the first main meal. Some common side effects of glimepiride (Amaryl) include headaches and low blood sugar. Like other medications in its class, it can also cause weight gain. Glimepiride (Amaryl) is available as both a brand name (Amaryl) and generic tablet.

Indications for Glimepiride

  • Type 2 diabetes in adults

Pros and Cons for Glimepiride

Pros

  • Available as a lower-cost generic medication
  • Only taken once a day
  • Taken by mouth

Cons

  • Need to take with the biggest meal of the day
  • More likely to cause weight gain compared to some other medications for diabetes
  • Might cause low blood sugar in breastfed babies and people ages 65 years and older

Common Side Effects for Glimepiride

  • Shakiness, anxiety, and other symptoms of low blood sugar levels (up to 20%)
  • Headache (8%)
  • Fever, cough, and other flu-like symptoms (5%)
  • Nausea (5%)
  • Dizziness (5%)

Warnings for Glimepiride

  • Low blood sugar
  • Serious allergic reactions
  • Risk of low red blood cell count (hemolytic anemia)
  • Possible risk of serious heart problems

Prices with our coupons for Jardiance vs. Glimepiride

Price Card Drug Icon
Jardiance30 tablets / 10mg
$350.61$809.93
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Price Card Drug Icon
Glimepiride180 tablets / 4mg
$19.66$19.66
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