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Compare Inpefa vs. Jardiance

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Inpefa (sotagliflozin) and Jardiance (empagliflozin) are both medications used to lower the risk of heart-related problems in people with heart failure and chronic kidney disease (CKD). They also help lower blood sugar in people with Type 2 diabetes, but Inpefa is not specifically approved to treat diabetes itself. Inpefa is a sodium-glucose cotransporter 1 and 2 (SGLT1/SGLT2) inhibitor, while Jardiance is only an SGLT2 inhibitor. This means Inpefa works in both the kidneys and the gut, whereas Jardiance works only in the kidneys. Inpefa is taken as a 200 mg or 400 mg tablet once daily, while Jardiance is taken as a 10 mg or 25 mg tablet once daily. Both medications can cause urinary tract infections, yeast infections, and increased urination. Inpefa may also cause diarrhea due to its effects on the gut. Neither medication has a generic version available yet. If you take other diabetes medications, both Inpefa and Jardiance can increase the risk of low blood sugar.

  • Inpefa (sotagliflozin)
    Jardiance (empagliflozin)
  • Inpefa (sotagliflozin)
    Jardiance (empagliflozin)

  • Summary of Inpefa vs. Jardiance

    Summary for SGLT1/SGLT2 inhibitor
    Prescription only

    Inpefa (sotagliflozin) is a newer medication that's approved to lessen the risk of heart-related complications in people with heart failure and in people with Type 2 diabetes, chronic kidney disease (CKD), and other heart-related conditions. This medication comes as a tablet that you take by mouth once daily. Side effects can include urinary tract infections (UTIs) and diarrhea. Inpefa (sotagliflozin) is expected to be available in the U.S. in summer 2023.

    Summary for SGLT2 inhibitor
    Prescription only

    Jardiance (empagliflozin) is a brand-name medication that's used along with a nutritious diet and routine exercise to improve blood sugar levels in people 10 years and older with Type 2 diabetes. It can also lower the chance of serious complications, hospitalization, and death in certain adults with heart failure or chronic kidney disease (CKD). Jardiance (empagliflozin) belongs to the drug class called sodium-glucose cotransporter 2 (SGLT2) inhibitors. It's a tablet that's taken by mouth once a day. Side effects can include urinary tract infections (UTIs), yeast infections, and weight loss.

  • Indications of Inpefa vs. Jardiance

    Indications for
    •Lessen the risk of heart-related death and complications in adults with:
    •Heart failure, or
    •Type 2 diabetes, chronic kidney disease, and other heart-related risk factors
    Indications for
    •Type 2 diabetes (in addition to diet and exercise) in people age 10 years and older
    •Lowering the risk of death due to heart problems in adults with Type 2 diabetes and heart disease
    •Lowering the risk of hospitalization and death due to heart problems in adults with heart failure
    •Lowering the risk of worsening kidney problems, hospitalization, and death due to heart problems in adults with chronic kidney disease (CKD)

  • Pros and Cons of Inpefa vs. Jardiance

    Pros and Const for SGLT1/SGLT2 inhibitor
    Pros
    •Taken just once a day
    •Can lower the risk of heart-related death, heart failure (HF) hospitalizations, and urgent HF visits by up to 33%
    •First-of-its-kind medication that blocks both SGLT1 and SGLT2 proteins
    Cons
    •Raises risk of UTIs and genital yeast infections
    •Newer medication, so there's no lower-cost generic version available yet
    •Unknown if safe or works well in people with severe kidney problems or are on dialysis
    Pros and Const for SGLT2 inhibitor
    Pros
    •Taken by mouth once a day
    •Unlikely to cause weight gain
    •Can take with other diabetes medications
    Cons
    •Raises risk of urinary tract infections (UTIs) and genital yeast infections
    •Might make you urinate more
    •Not recommended during the second and third trimesters of pregnancy

  • Common Side Effects of Inpefa vs. Jardiance

    Common Side Effects for
    •Urinary tract infection (9-12%)
    •Low fluid in the body (5-9%)
    •Diarrhea (7-8%)
    •Low blood sugar (4-8%)
    Common Side Effects for
    •Urinary tract infection (UTI; 8-9%)
    •Vaginal yeast infection in females (5-6%)
    •Upper respiratory tract infection (3-4%)
    •High cholesterol or fat levels (3-4%)
    •Urinating more than usual (3%)

  • Warnings of Inpefa vs. Jardiance

    Common Side Effects for
    •Ketoacidosis
    •Low fluids in the body (leading to low blood pressure or dehydration)
    •Genital and urinary tract infections
    •Low blood sugar when used with certain other diabetes medications
    Common Side Effects for
    •Ketoacidosis
    •Low fluids in the body (leading to low blood pressure or dehydration)
    •Genital and urinary tract infections
    •Low blood sugar (hypoglycemia) when used with certain other diabetes medications
    •Leg and foot amputations
    •Allergic reactions

  • Prices with our coupons for Inpefa vs. Jardiance

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