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Inpefa Coupon - Inpefa 200mg tablet

Inpefa

sotagliflozin
Used for Heart Failure, Diabetes Type 2
Used for Heart Failure, Diabetes Type 2

Inpefa (sotagliflozin) is a newer medication that's approved to lessen the risk of heart-related complications in people with heart failure and in people with Type 2 diabetes, chronic kidney disease (CKD), and other heart-related conditions. This medication comes as a tablet that you take by mouth once daily. Side effects can include urinary tract infections (UTIs) and diarrhea. Inpefa (sotagliflozin) is expected to be available in the U.S. in summer 2023.

Reviewed by:
reviewer
Allison Gourley, PharmD
reviewer
Kristianne Hannemann, PharmD
Last reviewed on June 25, 2023
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostAlternativesLatest newsImagesReferencesPricesMedicare
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What is Inpefa (sotagliflozin)?

What is Inpefa (sotagliflozin) used for?

How Inpefa (sotagliflozin) works

Inpefa (sotagliflozin) is a sodium-glucose cotransporter 1 and 2 (SGLT1/SGLT2) inhibitor. It blocks a protein in the kidneys called SGLT2. This prevents sugar and sodium (salt) from getting absorbed back into your body. This can help lower stress on your heart.

Inpefa (sotagliflozin) has the added benefit of working in the intestines (gut), where SGLT1 proteins are located. By blocking SGLT1, the medication prevents sugar and sodium absorption from the gut.

Drug Facts

Common BrandsInpefa
Drug ClassSGLT1/SGLT2 inhibitor
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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$736.29(save 55.38%)
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What are the side effects of Inpefa (sotagliflozin)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Urinary tract infection (9-12%)
  • Low fluid in the body (5-9%)
  • Diarrhea (7-8%)
  • Low blood sugar (4-8%)

Other Side Effects

  • Dizziness
  • Genital yeast infection

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Severe allergic reaction: swelling in the face, throat, tongue, or mouth; rash; trouble breathing
  • High ketone levels in the blood: nausea, vomiting, stomach pain, tiredness, thirsty, dry mouth, fruity breath, trouble breathing

Source: FDA

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Inpefa (sotagliflozin)

thumbs-up

Pros

Taken just once a day

Can lower the risk of heart-related death, heart failure (HF) hospitalizations, and urgent HF visits by up to [33%

First-of-its-kind medication that blocks both SGLT1 and SGLT2 proteins

thumbs-down

Cons

Raises risk of UTIs and genital yeast infections

Newer medication, so there's no lower-cost generic version available yet

Unknown if safe or works well in people with severe kidney problems or are on dialysis

pharmacist-tips

Pharmacist tips for Inpefa (sotagliflozin)

pharmacist

  • Take Inpefa (sotagliflozin) within an hour before breakfast or your first meal of the day. This will help make sure your body absorbs enough medication so it works well for you.

    • If you miss your Inpefa (sotagliflozin) dose by more than 6 hours, skip this missed dose. Then, take your next dose as prescribed on the next day. Don't double up to make up for a missed dose because this could lead to more side effects.

      • Practice good hygiene to prevent yeast and urinary tract infections since these are common side effects of Inpefa (sotagliflozin). Change clothes and shower as soon as possible after exercising or after a hot day. Also wear underwear and clothing made from breathable, natural materials like cotton.

        • Be sure to ask your provider how much fluid you should be drinking because Inpefa (sotagliflozin) can raise your risk for dehydration (low fluids in the body). If you feel dizzy, let your provider know.

          • Tell your provider if you're thinking of becoming pregnant, become pregnant, or are breastfeeding while taking Inpefa (sotagliflozin). This medication isn't recommended during the second and third trimesters of pregnancy or if you're breastfeeding because it can potentially harm your baby.

            faqs

            Frequently asked questions about Inpefa (sotagliflozin)

            What's the difference between Inpefa (sotagliflozin) and SGLT2 inhibitors?
            SGLT2 inhibitors, like Jardiance (empagliflozin) and Invokana (canagliflozin), are common diabetes medications that can lower blood sugar levels. They can also help lower the risk of worsening heart and kidney problems for certain people. SGLT2 inhibitors target the kidneys and block the absorption of sugar and sodium (salt) back into your body. On the other hand, Inpefa (sotagliflozin), an SGLT1/SGLT2 inhibitor, blocks the absorption of sugar and sodium from the kidneys and the gut. Inpefa (sotagliflozin) isn't approved to treat diabetes, but it's meant to lower the risk of heart problems in certain people, such as those with Type 2 diabetes. Studies suggest that Inpefa (sotagliflozin) might provide greater blood sugar control and protection from heart attack, stroke, and other heart-related complications than SGLT2 inhibitors in people with Type 2 diabetes.
            What's the best way to take Inpefa (sotagliflozin)?
            Take Inpefa (sotagliflozin) once a day in the morning, within an hour before breakfast. This will help keep levels of the medication consistent in your body to better help your condition. Taking Inpefa (sotagliflozin) on an empty stomach, on the other hand, will cause your body to absorb less medication.
            Does Inpefa (sotagliflozin) cause yeast infections?
            Inpefa (sotagliflozin) can raise your risk for genital yeast infections. In women, symptoms can include vaginal itching; white, thick discharge; and pain in the vagina or when urinating. In men, symptoms include redness, itching, or swelling of the penis. If you experience any of these symptoms while you're taking Inpefa (sotagliflozin), contact your provider. Some ways to help prevent yeast infections from happening include changing out of wet clothes and showering as soon as possible after exercising and wearing breathable, cotton underwear.
            Do I need to stop Inpefa (sotagliflozin) if I'm having surgery?
            Maybe; it depends on the type of surgery you're going to have. Make sure all of your providers know that you're taking Inpefa (sotagliflozin), and tell them ahead of time of any surgeries or procedures that require you to fast. You'll probably need to stop taking Inpefa (sotagliflozin) for at least 3 days before these types of major surgeries or procedures. Your provider will let you know when it's safe to start the medication again after your procedure.
            Can I take Inpefa (sotagliflozin) if I'm pregnant?
            There's not enough data to know whether Inpefa (sotagliflozin) is safe for pregnant women to take. In animal studies, Inpefa (sotagliflozin) caused harm to unborn babies during the second and third trimesters, but this doesn't always mean the same thing will happen for humans. What is known, however, is that pregnant women with untreated heart failure are at a higher risk for preterm birth and other complications. If you're pregnant or planning to become pregnant, have a discussion with your provider about the best heart failure treatment for you.
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            What are the risks and warnings for Inpefa (sotagliflozin)?

            Inpefa (sotagliflozin) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

            risk-warning

            Ketoacidosis

            • Risk factors: Diabetes | Illness | Lowered calorie intake | Insulin dose reduction | Pancreatic problems | Surgery | Alcohol abuse

              Some people with diabetes taking Inpefa (sotagliflozin) have experienced a serious life-threatening condition called ketoacidosis. This can happen when your body makes too many ketones, which makes your blood acidic. Your risk might be higher if you're ill, eating less calories, drinking a lot of alcohol, or have recently had surgery or a reduction in your insulin dose. If possible, check your ketone levels if you experience dry mouth, fruity breath, tiredness, nausea, vomiting, stomach pain, or trouble breathing. If any of these symptoms happen, stop taking Inpefa (sotagliflozin) and get medical help right away.

              risk-warning

              Low fluids in the body (leading to low blood pressure or dehydration)

              • Risk factors: Age 65 years or older | Kidney problems | Taking other medications that lower blood pressure, like loop diuretics (water pills) | Low-salt diet

                Inpefa (sotagliflozin) can cause low levels of fluids in the body. This can lead to dehydration, low blood pressure, or kidney damage. You're more likely at risk if you already have kidney problems or take water pills known as loop diuretics. Your provider might regularly check your kidney health with blood tests. Make sure to stay hydrated while you're taking Inpefa (sotagliflozin), and ask your provider how much fluid you should be drinking. Talk to your provider if you experience dizziness, lightheadedness, or if you're urinating less than usual. Also let them know if you're vomiting or have diarrhea (you're also losing liquids from your body this way, which can lead to dehydration). Your provider can recommend ways to keep your body fluids up.

                risk-warning

                Genital and urinary tract infections

                • Risk factors: History of genital yeast infections or urinary tract infections (UTIs)

                  Inpefa (sotagliflozin) raises the risk of genital infections, like yeast infections and UTIs. Although rare, these infections can become serious and require hospitalization. Call your provider if you experience a burning feeling when urinating; a need to urinate often; lower stomach pain; blood in your urine; an odor from your genitals; or pain, itching, swelling, redness, or tenderness around your genitals.

                  risk-warning

                  Low blood sugar when used with certain other diabetes medications

                  • Risk factors: Changes in diet and exercise | Drinking alcohol | Taking certain other medications for diabetes

                    When taken together with certain other diabetes medications, such as insulin and sulfonylureas like glimepiride, Inpefa (sotagliflozin) can raise your risk for low blood sugar (hypoglycemia). Very low blood sugar can be life-threatening. Symptoms of low blood sugar include feeling shaky, being nervous or anxious, having a fast heartbeat, sweating or body chills, confusion, feeling sleepy or weak, and excessive hunger. If you take other diabetes medications with Inpefa (sotagliflozin) and you experience any of these symptoms, be sure to check your blood sugar.

                    dosage

                    Inpefa (sotagliflozin) dosage forms

                    The average cost for 30 tablets of 200mg of Inpefa (sotagliflozin) is $328.54 with a free GoodRx coupon. This is 55.38% off the average retail price of $736.29.
                    tablet
                    Tablet
                    DosageQuantityPrice as low asPrice per unit
                    200mg30 tablets$328.54$10.95
                    400mg30 tablets$328.54$10.95

                    Typical dosing for Inpefa (sotagliflozin)

                    The typical starting dose is 200 mg by mouth daily within an hour before breakfast (or your first meal of the day). If you're able to handle taking that dose for a couple of weeks, your provider will probably raise your dose to 400 mg daily.

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                    How much does Inpefa (sotagliflozin) cost?

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                    Inpefa (brand)
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                    alternatives

                    What are alternatives to Inpefa (sotagliflozin)?

                    There are a number of medications that your doctor can prescribe in place of Inpefa (sotagliflozin). Compare a few possible alternatives below.
                    Inpefa (sotagliflozin)
                    Used for:
                    $328.54 Lowest GoodRx priceView Prices
                    Jardiance (empagliflozin)
                    Used for:

                    • Type 2 diabetes (in addition to diet and exercise) in people age 10 years and older

                    • Lowering the risk of death due to heart problems in adults with Type 2 diabetes and heart disease

                    • Lowering the risk of hospitalization and death due to heart problems in adults with heart failure

                    • Lowering the risk of worsening kidney problems, hospitalization, and death due to heart problems in adults with chronic kidney disease (CKD)

                    $619.13 Lowest GoodRx priceView Prices
                    Farxiga (dapagliflozin)
                    Used for:

                    • Type 2 diabetes (in addition to diet and exercise) in people age 10 and over

                    • Lowering the risk of hospitalization for heart failure in adults with Type 2 diabetes and heart disease

                    • Lowering the risk of hospitalization and death due to heart problems in people with heart failure

                    • Lowering the risk of worsening kidney problems, hospitalization for heart failure, and death due to heart problems in adults with chronic kidney disease (CKD)

                    $578.11 Lowest GoodRx priceView Prices
                    images

                    Inpefa (sotagliflozin) images

                    Blue Oval Lex And 200 - Inpefa 200mg Tablet
                    This medicine is Blue, Oval Tablet Imprinted With "200" And "Lex".Blue Oval Lex And 200 - Inpefa 200mg Tablet
                    Blue Oval Lex And 200 - Inpefa 200mg Tablet
                    This medicine is Blue, Oval Tablet Imprinted With "200" And "Lex".Blue Oval Lex And 200 - Inpefa 200mg Tablet

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                    References

                    Best studies we found

                    American Diabetes Association. (n.d.). Diabetes & DKA (ketoacidosis).

                    Bhatt, D.L., et al. (2021). Sotagliflozin in patients with diabetes and recent worsening heart failure. The New England Journal of Medicine.

                    Lexicon Pharmaceuticals, Inc. (2023). Inpefa (sotagliflozin) tablets, for oral use [package insert].

                    View All References (4)

                    Lexicon Pharmaceuticals, Inc. (2023). Lexicon announces FDA approval of Inpefa™ (sotagliflozin) for treatment of heart failure.

                    National Kidney Foundation. (n.d.). Dialysis.

                    Pitt, B., et al. (2021). Does SGLT1 inhibition add benefit to SGLT2 inhibition in Type 2 diabetes? Circulation.

                    Sanvictores, T., et al. (2023). Physiology, fasting. StatPearls.

                    GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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