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Compare Jardiance vs. Glyburide

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Jardiance (empagliflozin) and Glyburide are both medications used to manage Type 2 diabetes, but they work in different ways and have distinct characteristics. Jardiance is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that helps lower blood sugar by causing your body to excrete excess sugar through urine. It also has benefits for heart failure and chronic kidney disease. Glyburide, on the other hand, is a sulfonylurea that lowers blood sugar by prompting your pancreas to release more insulin. Jardiance is taken once daily and is currently only available as a brand-name medication, with generics expected after 2025. Glyburide can be taken once or twice daily and is available in both generic and micronized forms. While Jardiance can cause urinary tract and yeast infections, Glyburide has a higher risk of causing low blood sugar and weight gain. Additionally, Jardiance is not recommended during the later stages of pregnancy, whereas glyburide's safety during pregnancy is not well-studied.

  • Jardiance (empagliflozin)
    Glyburide
  • Jardiance (empagliflozin)
    Glyburide

  • Summary of Jardiance vs. Glyburide

    Summary for SGLT2 inhibitor
    Prescription only

    Jardiance (empagliflozin) is a brand-name medication that's used along with a nutritious diet and routine exercise to improve blood sugar levels in people 10 years and older with Type 2 diabetes. It can also lower the chance of serious complications, hospitalization, and death in certain adults with heart failure or chronic kidney disease (CKD). Jardiance (empagliflozin) belongs to the drug class called sodium-glucose cotransporter 2 (SGLT2) inhibitors. It's a tablet that's taken by mouth once a day. Side effects can include urinary tract infections (UTIs), yeast infections, and weight loss.

    Summary for Sulfonylurea
    Prescription only

    Glyburide is taken by mouth to lower blood sugar levels for people who have Type 2 diabetes. This medication isn't meant to be taken alone, but in addition to eating a healthy diet and engaging in regular exercise. Glyburide is typically taken once or twice daily, depending on your dose.

  • Indications of Jardiance vs. Glyburide

    Indications for
    •Type 2 diabetes (in addition to diet and exercise) in people age 10 years and older
    •Lowering the risk of death due to heart problems in adults with Type 2 diabetes and heart disease
    •Lowering the risk of hospitalization and death due to heart problems in adults with heart failure
    •Lowering the risk of worsening kidney problems, hospitalization, and death due to heart problems in adults with chronic kidney disease (CKD)
    Indications for
    •Type 2 diabetes

  • Pros and Cons of Jardiance vs. Glyburide

    Pros and Const for SGLT2 inhibitor
    Pros
    •Taken by mouth once a day
    •Unlikely to cause weight gain
    •Can take with other diabetes medications
    Cons
    •Raises risk of urinary tract infections (UTIs) and genital yeast infections
    •Might make you urinate more
    •Not recommended during the second and third trimesters of pregnancy
    Pros and Const for Sulfonylurea
    Pros
    •Usually taken only once daily with largest meal
    •Can lower A1C levels by 1.5%
    •Taken by mouth, so good option for people who don't like injections
    •Can be taken with some other blood sugar medications, such as metformin
    Cons
    •Risk of low blood sugar (hypoglycemia), especially if you have kidney or liver problems
    •More likely to cause low blood sugar than other blood sugar medications, such as metformin
    •Can cause some weight gain
    •Not approved for Type 1 diabetes

  • Common Side Effects of Jardiance vs. Glyburide

    Common Side Effects for
    •Urinary tract infection (UTI; 8-9%)
    •Vaginal yeast infection in females (5-6%)
    •Upper respiratory tract infection (3-4%)
    •High cholesterol or fat levels (3-4%)
    •Urinating more than usual (3%)
    Common Side Effects for
    •Feeling bloated
    •Nausea
    •Heartburn

  • Warnings of Jardiance vs. Glyburide

    Common Side Effects for
    •Ketoacidosis
    •Low fluids in the body (leading to low blood pressure or dehydration)
    •Genital and urinary tract infections
    •Low blood sugar (hypoglycemia) when used with certain other diabetes medications
    •Leg and foot amputations
    •Allergic reactions
    Common Side Effects for
    •Low blood sugar (hypoglycemia)
    •Possible risk of heart problems
    •Breakdown of red blood cells

  • Prices with our coupons for Jardiance vs. Glyburide

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    Learn more about Glyburide

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