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Compare Jardiance vs. Trulicity

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Jardiance (empagliflozin) and Trulicity (dulaglutide) are both medications used to manage Type 2 diabetes, but they work in different ways and have different forms. Jardiance is an oral tablet taken once daily, while Trulicity is an injectable medication used once a week. Jardiance is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that helps your kidneys remove excess sugar through urine, and it also helps with heart failure and chronic kidney disease. On the other hand, Trulicity is a Glucagon-like peptide-1 (GLP-1) agonist that helps your body release more insulin, slows digestion, and reduces sugar release into the bloodstream. Jardiance can cause urinary tract infections and yeast infections, while Trulicity often causes nausea and other stomach issues. Currently, Jardiance does not have a generic version available until at least 2025, whereas Trulicity is only available as a brand-name medication. Both medications can help with weight loss, but neither is specifically approved for this purpose.

Jardiance (empagliflozin)
Trulicity (dulaglutide)
Jardiance (empagliflozin)
Trulicity (dulaglutide)
Summary of Jardiance vs. Trulicity
Summary for SGLT2 inhibitor
Prescription only
Jardiance (empagliflozin) is a brand-name medication that's used along with a nutritious diet and routine exercise to improve blood sugar levels in people 10 years and older with Type 2 diabetes. It can also lower the chance of serious complications, hospitalization, and death in certain adults with heart failure or chronic kidney disease (CKD). Jardiance (empagliflozin) belongs to the drug class called sodium-glucose cotransporter 2 (SGLT2) inhibitors. It's a tablet that's taken by mouth once a day. Side effects can include urinary tract infections (UTIs), yeast infections, and weight loss.
Summary for GLP-1 agonist
Prescription only
Trulicity (dulaglutide) is a glucagon-like peptide-1 (GLP-1) agonist that helps control blood sugar in people 10 years and older with Type 2 diabetes. It's also approved to lower the risk of heart problems like heart attacks, strokes, and heart-related death in certain adults with Type 2 diabetes. The medication is injected under the skin once a week. Common side effects include nausea, vomiting, diarrhea, and stomach pain. When taken with certain diabetes medications like insulin, there's a higher risk of low blood sugar (hypoglycemia).
Indications of Jardiance vs. Trulicity
Indications for

•Type 2 diabetes (in addition to diet and exercise) in people age 10 years and older

•Lowering the risk of death due to heart problems in adults with Type 2 diabetes and heart disease

•Lowering the risk of hospitalization and death due to heart problems in adults with heart failure

•Lowering the risk of worsening kidney problems, hospitalization, and death due to heart problems in adults with chronic kidney disease (CKD)

Indications for

•Manage Type 2 diabetes in people 10 years and older, along with diet and exercise

•Lower the risk of heart problems like heart attack, stroke, or death in adults with Type 2 diabetes who have heart disease or heart-related risk factors
Pros and Cons of Jardiance vs. Trulicity
Pros and Const for SGLT2 inhibitor
Pros

•Taken by mouth once a day

•Unlikely to cause weight gain

•Can take with other diabetes medications

Cons

•Raises risk of urinary tract infections (UTIs) and genital yeast infections

•Might make you urinate more

•Not recommended during the second and third trimesters of pregnancy

Pros and Const for GLP-1 agonist
Pros

•Works well at lowering A1C

•Comes as a ready-to-use injectable pen

•Only used once a week

•Helps with weight loss

Cons

•Commonly causes nausea, vomiting, diarrhea, and stomach pain

•Potential risk for thyroid tumors

•Can cause problems in the pancreas, kidney, and gallbladder

•Not recommended for people with stomach problems
Common Side Effects of Jardiance vs. Trulicity
Common Side Effects for

•Urinary tract infection (UTI; 8-9%)

•Vaginal yeast infection in females (5-6%)

•Upper respiratory tract infection (3-4%)

•High cholesterol or fat levels (3-4%)

•Urinating more than usual (3%)

Common Side Effects for

•Nausea (12-21%)

•Diarrhea (7-13%)

•Vomiting (6-13%)

•Stomach pain (7-9%)

•Low appetite (5-9%)

•Fatigue (4-6%)

•Indigestion (3-6%)
Warnings of Jardiance vs. Trulicity
Common Side Effects for

•Ketoacidosis

•Low fluids in the body (leading to low blood pressure or dehydration)

•Genital and urinary tract infections

•Low blood sugar (hypoglycemia) when used with certain other diabetes medications

•Leg and foot amputations

•Allergic reactions

Common Side Effects for

•Thyroid cancer

•Inflammation of the pancreas (pancreatitis)

•Low blood sugar when used with certain diabetes medications

•Severe allergic reactions

•Kidney damage

•Severe stomach-related side effects

•Worsening eye problems in people with diabetic retinopathy

•Gallbladder problems

•Breathing fluid into your lungs during anesthesia or deep sedation
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Compare Jardiance vs. Trulicity

Key takeaways

Summary of Jardiance vs. Trulicity

Indications of Jardiance vs. Trulicity

Pros and Cons of Jardiance vs. Trulicity

Common Side Effects of Jardiance vs. Trulicity

Warnings of Jardiance vs. Trulicity

Prices with our coupons for Jardiance vs. Trulicity

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