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Compare Jardiance vs. Invokamet

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Jardiance (empagliflozin) and Invokamet (canagliflozin/metformin) are both medications used to manage Type 2 diabetes, but they have some key differences. Jardiance is a single medication that belongs to a sodium-glucose co-transporter 2 (SGLT2) inhibitor class and is taken once daily. It helps lower blood sugar by causing your body to excrete excess sugar through urine and can also reduce the risk of heart and kidney complications. Invokamet, on the other hand, is a combination of two medications: canagliflozin (an SGLT2 inhibitor) and metformin (a biguanide). It is available in both immediate-release tablets taken twice daily and extended-release tablets taken once daily. While both medications can cause urinary tract infections and genital infections, Invokamet also has a risk of lowering vitamin B12 levels and causing bone fractures. Additionally, Jardiance is currently only available as a brand-name medication, with generics expected after 2025, whereas Invokamet is also brand-only. Both medications require a prescription and should be taken with a healthy diet and exercise.

  • Jardiance (empagliflozin)
    Invokamet (canagliflozin / metformin)
  • Jardiance (empagliflozin)
    Invokamet (canagliflozin / metformin)

  • Summary of Jardiance vs. Invokamet

    Summary for SGLT2 inhibitor
    Prescription only

    Jardiance (empagliflozin) is a brand-name medication that's used along with a nutritious diet and routine exercise to improve blood sugar levels in people 10 years and older with Type 2 diabetes. It can also lower the chance of serious complications, hospitalization, and death in certain adults with heart failure or chronic kidney disease (CKD). Jardiance (empagliflozin) belongs to the drug class called sodium-glucose cotransporter 2 (SGLT2) inhibitors. It's a tablet that's taken by mouth once a day. Side effects can include urinary tract infections (UTIs), yeast infections, and weight loss.

    Summary for SGLT2 inhibitor / Biguanide
    Prescription only

    Invokamet (canagliflozin / metformin) is a combination medication used along with diet and exercise to lower blood sugar levels in adults with Type 2 diabetes. It's available as immediate-release tablets that are taken twice daily, as well as extended-release tablets that are taken once daily. This medication raises the risk of urinary tract infections (UTIs) and genital infections.

  • Indications of Jardiance vs. Invokamet

    Indications for
    •Type 2 diabetes (in addition to diet and exercise) in people age 10 years and older
    •Lowering the risk of death due to heart problems in adults with Type 2 diabetes and heart disease
    •Lowering the risk of hospitalization and death due to heart problems in adults with heart failure
    •Lowering the risk of worsening kidney problems, hospitalization, and death due to heart problems in adults with chronic kidney disease (CKD)
    Indications for
    •Type 2 diabetes
    •To lower the risk of major heart events (e.g., heart attack, stroke) in adults with Type 2 diabetes and heart disease
    •To lower the risk of hospitalization for heart failure, death due to heart problems, and worsening of kidney problems in certain adults with Type 2 diabetes and diabetic kidney disease

  • Pros and Cons of Jardiance vs. Invokamet

    Pros and Const for SGLT2 inhibitor
    Pros
    •Taken by mouth once a day
    •Unlikely to cause weight gain
    •Can take with other diabetes medications
    Cons
    •Raises risk of urinary tract infections (UTIs) and genital yeast infections
    •Might make you urinate more
    •Not recommended during the second and third trimesters of pregnancy
    Pros and Const for SGLT2 inhibitor / Biguanide
    Pros
    •Combines two medications into one pill
    •Available as an extended-release tablet that lasts throughout the day (Invokamet XR)
    •Can lower A1C (a blood test that measures your average sugar level over time) by up to 1.8% in people who aren't already taking either Invokana (canagliflozin) or metformin
    •Dose can be adjusted based on how well the medication is working for you
    Cons
    •Might cause more urination
    •Can lower vitamin B12 levels
    •Raises the risk of urinary tract infections (UTIs), genital infections, and bone fractures
    •Only available as brand

  • Common Side Effects of Jardiance vs. Invokamet

    Common Side Effects for
    •Urinary tract infection (UTI; 8-9%)
    •Vaginal yeast infection in females (5-6%)
    •Upper respiratory tract infection (3-4%)
    •High cholesterol or fat levels (3-4%)
    •Urinating more than usual (3%)
    Common Side Effects for
    •Vaginal yeast infection in females (11-12%)
    •Urinary tract infections (UTIs; 4-6%)
    •More urination (5%)
    •Male genital yeast or fungal infections (4%)
    •Diarrhea (4%)

  • Warnings of Jardiance vs. Invokamet

    Common Side Effects for
    •Ketoacidosis
    •Low fluids in the body (leading to low blood pressure or dehydration)
    •Genital and urinary tract infections
    •Low blood sugar (hypoglycemia) when used with certain other diabetes medications
    •Leg and foot amputations
    •Allergic reactions
    Common Side Effects for
    •Lactic acidosis
    •Leg and foot amputations
    •Ketoacidosis
    •Low fluids in the body (leading to low blood pressure or dehydration)
    •Genital and urinary tract infections
    •Low blood sugar (hypoglycemia) when used with certain other diabetes medications
    •Severe allergic reactions
    •Bone fractures
    •Low vitamin B12 levels

  • Prices with our coupons for Jardiance vs. Invokamet

    Learn more about Jardiance
    Learn more about Invokamet

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