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Compare Glyxambi vs. Jardiance

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Glyxambi (empagliflozin/linagliptin) and Jardiance (empagliflozin) are both used to treat Type 2 diabetes, but they have some key differences. Glyxambi is a combination of two medications: empagliflozin, an SGLT2 inhibitor, and linagliptin, a DPP-4 inhibitor. Jardiance, on the other hand, contains only empagliflozin. Glyxambi can lower the risk of death from heart disease in people with Type 2 diabetes and heart disease, while Jardiance can also lower the risk of hospitalization and death in adults with heart failure or chronic kidney disease. Glyxambi is taken once daily in the morning, and Jardiance is also taken once daily, but it can be taken at any time of day. Both medications can cause urinary tract infections and yeast infections. Additionally, Jardiance is currently only available as a brand-name medication, with generics expected in 2025, while Glyxambi does not have a generic form available.

  • Glyxambi (empagliflozin / linagliptin)
    Jardiance (empagliflozin)
  • Glyxambi (empagliflozin / linagliptin)
    Jardiance (empagliflozin)

  • Summary of Glyxambi vs. Jardiance

    Summary for SGLT2 inhibitor / DPP-4 inhibitor
    Prescription only

    Glyxambi (empagliflozin / linagliptin) is used to manage blood sugar levels in adults with Type 2 diabetes. It's a combination of 2 medications: empagliflozin (a sodium-glucose co-transporter 2 (SGLT2) inhibitor) and linagliptin (a dipeptidyl peptidase-4 (DPP-4) inhibitor). It lowers blood sugar by getting rid of extra sugar through your urine and helping your body make more insulin. Glyxambi (empagliflozin / linagliptin) is taken by mouth once daily. Some common side effects include urinary tract infections and upper respiratory tract infections.

    Summary for SGLT2 inhibitor
    Prescription only

    Jardiance (empagliflozin) is a brand-name medication that's used along with a nutritious diet and routine exercise to improve blood sugar levels in people 10 years and older with Type 2 diabetes. It can also lower the chance of serious complications, hospitalization, and death in certain adults with heart failure or chronic kidney disease (CKD). Jardiance (empagliflozin) belongs to the drug class called sodium-glucose cotransporter 2 (SGLT2) inhibitors. It's a tablet that's taken by mouth once a day. Side effects can include urinary tract infections (UTIs), yeast infections, and weight loss.

  • Indications of Glyxambi vs. Jardiance

    Indications for
    •Type 2 diabetes in adults (when taken along with nutritious diet and regular exercise)
    •Lowers risk of death from heart problems in adults with Type 2 diabetes and heart disease
    Indications for
    •Type 2 diabetes (in addition to diet and exercise) in people age 10 years and older
    •Lowering the risk of death due to heart problems in adults with Type 2 diabetes and heart disease
    •Lowering the risk of hospitalization and death due to heart problems in adults with heart failure
    •Lowering the risk of worsening kidney problems, hospitalization, and death due to heart problems in adults with chronic kidney disease (CKD)

  • Pros and Cons of Glyxambi vs. Jardiance

    Pros and Const for SGLT2 inhibitor / DPP-4 inhibitor
    Pros
    •Combines two medications into one pill for convenience
    •Can lower the risk of death from heart attack or stroke in people with Type 2 diabetes and heart disease
    •Only taken once a day in the morning with or without food
    •Not likely to cause weight gain
    Cons
    •Not safe for use in people on dialysis
    •Not approved for people with Type 1 diabetes
    •Might cause you to urinate more often
    •Might cause urinary tract infections or genital yeast infections
    Pros and Const for SGLT2 inhibitor
    Pros
    •Taken by mouth once a day
    •Unlikely to cause weight gain
    •Can take with other diabetes medications
    Cons
    •Raises risk of urinary tract infections (UTIs) and genital yeast infections
    •Might make you urinate more
    •Not recommended during the second and third trimesters of pregnancy

  • Common Side Effects of Glyxambi vs. Jardiance

    Common Side Effects for
    •Urinary tract infection (11-13%)
    •Upper respiratory tract infection (7%)
    Common Side Effects for
    •Urinary tract infection (UTI; 8-9%)
    •Vaginal yeast infection in females (5-6%)
    •Upper respiratory tract infection (3-4%)
    •High cholesterol or fat levels (3-4%)
    •Urinating more than usual (3%)

  • Warnings of Glyxambi vs. Jardiance

    Common Side Effects for
    •Pancreas problems
    •Ketoacidosis (too much acid in the blood)
    •Low fluids in the body (leading to low blood pressure or dehydration, or kidney problems)
    •Low blood sugar with other diabetes medications
    •Genital and urinary tract infections
    •Serious allergic or skin reactions
    •Joint pain
    •Leg and foot amputations
    •Heart failure
    Common Side Effects for
    •Ketoacidosis
    •Low fluids in the body (leading to low blood pressure or dehydration)
    •Genital and urinary tract infections
    •Low blood sugar (hypoglycemia) when used with certain other diabetes medications
    •Leg and foot amputations
    •Allergic reactions

  • Prices with our coupons for Glyxambi vs. Jardiance

    Learn more about Glyxambi
    Learn more about Jardiance

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