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Compare Glyxambi vs. Metaglip

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Glyxambi (empagliflozin/linagliptin) and glipizide/metformin are both combination medications used to treat Type 2 diabetes, but they work in different ways and have distinct characteristics. Glyxambi combines an SGLT2 inhibitor and a DPP-4 inhibitor, which help lower blood sugar by preventing sugar reabsorption in the kidneys and by increasing insulin production, respectively. On the other hand, glipizide/metformin combines a sulfonylurea and a biguanide, which work by stimulating insulin release from the pancreas and reducing sugar production and absorption in the body. Glyxambi is taken once daily, while glipizide/metformin is usually taken once or twice per day. Glyxambi can lower the risk of death from heart disease in people with Type 2 diabetes and heart disease, whereas glipizide/metformin has a warning about potential heart-related risks. Additionally, neither medication is recommended for use during pregnancy. Both medications can cause low blood sugar and urinary tract infections. Glipizide/metformin can lead to lactic acidosis and low vitamin B12 levels, while Glyxambi can cause inflammation in your pancreas.

  • Glyxambi (empagliflozin / linagliptin)
    Glipizide/metformin
  • Glyxambi (empagliflozin / linagliptin)
    Glipizide/metformin

  • Summary of Glyxambi vs. Metaglip

    Summary for SGLT2 inhibitor / DPP-4 inhibitor
    Prescription only

    Glyxambi (empagliflozin / linagliptin) is used to manage blood sugar levels in adults with Type 2 diabetes. It's a combination of 2 medications: empagliflozin (a sodium-glucose co-transporter 2 (SGLT2) inhibitor) and linagliptin (a dipeptidyl peptidase-4 (DPP-4) inhibitor). It lowers blood sugar by getting rid of extra sugar through your urine and helping your body make more insulin. Glyxambi (empagliflozin / linagliptin) is taken by mouth once daily. Some common side effects include urinary tract infections and upper respiratory tract infections.

    Summary for Sulfonylurea / Biguanide
    Prescription only

    Glipizide/metformin combines two diabetes medications into one tablet: glipizide (a sulfonylurea) and metformin (a biguanide). It's approved to treat Type 2 diabetes in adults along with diet and exercise. This medication is typically taken by mouth once or twice a day. Some common side effects of glipizide/metformin can include diarrhea and headache; it isn't likely to cause weight gain or weight loss.

  • Indications of Glyxambi vs. Metaglip

    Indications for
    •Type 2 diabetes in adults (when taken along with nutritious diet and regular exercise)
    •Lowers risk of death from heart problems in adults with Type 2 diabetes and heart disease
    Indications for
    •Type 2 diabetes

  • Pros and Cons of Glyxambi vs. Metaglip

    Pros and Const for SGLT2 inhibitor / DPP-4 inhibitor
    Pros
    •Combines two medications into one pill for convenience
    •Can lower the risk of death from heart attack or stroke in people with Type 2 diabetes and heart disease
    •Only taken once a day in the morning with or without food
    •Not likely to cause weight gain
    Cons
    •Not safe for use in people on dialysis
    •Not approved for people with Type 1 diabetes
    •Might cause you to urinate more often
    •Might cause urinary tract infections or genital yeast infections
    Pros and Const for Sulfonylurea / Biguanide
    Pros
    •Taken by mouth
    •Combination medication, so more convenient to take
    •Available as a lower-cost generic
    Cons
    •Need to take with meals
    •Can't take during pregnancy
    •Not an option for children

  • Common Side Effects of Glyxambi vs. Metaglip

    Common Side Effects for
    •Urinary tract infection (11-13%)
    •Upper respiratory tract infection (7%)
    Common Side Effects for
    •Diarrhea (18%)
    •Headache (13%)
    •Cold or flu infection (10%)
    •Low blood sugar levels (9%)
    •Muscle pain (8%)
    •Nausea, vomiting (8%)
    •Stomach pain (6%)
    •Dizziness (5%)

  • Warnings of Glyxambi vs. Metaglip

    Common Side Effects for
    •Pancreas problems
    •Ketoacidosis (too much acid in the blood)
    •Low fluids in the body (leading to low blood pressure or dehydration, or kidney problems)
    •Low blood sugar with other diabetes medications
    •Genital and urinary tract infections
    •Serious allergic or skin reactions
    •Joint pain
    •Leg and foot amputations
    •Heart failure
    Common Side Effects for
    •Lactic acidosis
    •Possible risk of serious heart problems
    •Low blood sugar levels
    •Low vitamin B12 levels

  • Prices with our coupons for Glyxambi vs. Metaglip

    Learn more about Glyxambi
    Learn more about Glipizide/metformin

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