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Compare Invokana vs. Glucovance

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Invokana (canagliflozin) and glyburide / metformin are both medications used to manage Type 2 diabetes. They help control blood sugar levels when combined with a healthy diet and exercise. However, they belong to different medication classes. Invokana is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, which works by preventing sugar reabsorption in the kidneys, while glyburide / metformin combines a sulfonylurea and a biguanide to increase insulin release and reduce sugar production in the liver. Invokana is taken once daily, whereas glyburide / metformin is typically taken once or twice daily with meals. Invokana is only available as a brand-name medication, while glyburide / metformin is available in generic form. Glyburide / metformin used to be available under the brand name Glucovance. Common side effects of Invokana include urinary tract infections, yeast infections, and increased urination, while glyburide / metformin can cause low blood sugar and gastrointestinal issues like diarrhea.

  • Invokana (canagliflozin)
    Glyburide/metformin
  • Invokana (canagliflozin)
    Glyburide/metformin

  • Summary of Invokana vs. Glucovance

    Summary for SGLT2 inhibitor
    Prescription only

    Invokana (canagliflozin) is a medication that's used together with a healthy diet and exercise to lower blood sugar levels in adults with Type 2 diabetes. It can also lessen the chance of worsening heart and kidney problems in some people with Type 2 diabetes. This medication is taken by mouth once a day.

    Summary for Sulfonylurea / Biguanide
    Prescription only

    Glyburide/metformin is used to manage blood sugar levels in adults with Type 2 diabetes. It works best when taken with a healthy diet and regular exercise. This medication combines a sulfonylurea (glyburide) and a biguanide (metformin). You take it by mouth, typically once or twice daily with meals. Since glyburide/metformin can cause hypoglycemia (low blood sugar), it's important to carry fast-acting sugars like gummy candy or fruit juice to quickly raise your blood sugar if needed. Other common side effects include diarrhea, headache, and nausea. Brand name Glucovance has been discontinued.

  • Indications of Invokana vs. Glucovance

    Indications for
    •Type 2 diabetes
    •Lowering the risk of major heart events (e.g., heart attack, stroke) in adults with Type 2 diabetes and heart disease
    •Lowering the risk of hospitalization for heart failure, death due to heart problems, and worsening of kidney problems in certain adults with Type 2 diabetes and diabetic kidney disease
    Indications for
    •Type 2 diabetes (T2D) in adults

  • Pros and Cons of Invokana vs. Glucovance

    Pros and Const for SGLT2 inhibitor
    Pros
    •Only taken once a day
    •Can use alone or together with other diabetes medications
    •Dose can be adjusted based on how well the medication is working for you
    Cons
    •Only available as brand only
    •Might raise the risk of genital infections or bone fracture
    •Not recommended in second and third trimesters of pregnancy
    •Unknown if safe or works well in people on dialysis
    Pros and Const for Sulfonylurea / Biguanide
    Pros
    •Combines two medications into one pill for convenience
    •Dose can be adjusted if needed
    •Taken by mouth instead of an injection
    Cons
    •Need to take with meals
    •Not safe for use in people with moderate-to-severe kidney disease
    •More likely to cause weight gain compared to some other medications for diabetes

  • Common Side Effects of Invokana vs. Glucovance

    Common Side Effects for
    •Vaginal yeast infection in females (11-12%)
    •Urinary tract infections (UTIs; 4-6%)
    •More urination (5%)
    Common Side Effects for
    •Low blood sugar levels (up to 38%)
    •Diarrhea (17%)
    •Headache (9%)
    •Nausea or vomiting (8%)
    •Belly pain (7%)
    •Dizziness (6%)

  • Warnings of Invokana vs. Glucovance

    Common Side Effects for
    •Leg and foot amputations
    •Ketoacidosis
    •Low fluids in the body (leading to low blood pressure or dehydration)
    •Genital and urinary tract infections
    •Low blood sugar (hypoglycemia) when used with certain other diabetes medications
    •Severe allergic reactions
    •Bone fractures
    Common Side Effects for
    •Lactic acidosis (too much acid in your body)
    •Low blood sugar
    •Possible risk of serious heart problems
    •Risk of low red blood cell count (hemolytic anemia)
    •Low vitamin B12 levels

  • Prices with our coupons for Invokana vs. Glucovance

    Learn more about Invokana
    Learn more about Glyburide/metformin

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