Invokana

Although rare, Invokana (canagliflozin) can raise your risk of needing foot or leg amputations. Your risk might be higher if you have a history of amputation, blood vessel problems, or nerve problems. In studies, the most common reasons for amputations for people who took Invokana (canagliflozin) were leg infections, damaged leg tissue, and diabetic foot ulcers. Let your provider know if you experience any new pain, tenderness, sores, ulcers, or infections on your legs or feet. Your provider can recommend ways to manage these foot problems or treat them before they get worse. Follow up with your provider regularly so they can perform foot exams.

Some people with diabetes taking Invokana (canagliflozin) have experienced a serious condition called ketoacidosis. This can be life-threatening and happens when your body makes too many ketones, which makes your blood acidic. Your risk might be higher if you're eating less calories, taking a higher dose of Invokana (canagliflozin), are ill, have recently had surgery, or have had a recent reduction in your insulin dose. Check your ketones if you experience dry mouth, fruity breath, tiredness, nausea, vomiting, stomach pain, or trouble breathing. Get medical help right away if any of these symptoms happen.

Invokana (canagliflozin) can cause low levels of fluids in the body. Low fluids can lead to low blood pressure or kidney injury. Your risk is higher if you already have kidney problems, are 65 years or older, are on a low-sodium diet, or take water pills known as loop diuretics. Your provider will check your kidneys with blood tests to make sure they're working properly. Stay hydrated while you're taking this medication. Contact your provider if you experience dizziness or if you're urinating less than usual. Also tell them if you have vomiting or diarrhea so they can make sure you're not losing too much fluid from your body.

Invokana (canagliflozin) raises the risk of genital infections, like UTIs and yeast infections. In some cases, these infections can become serious and require hospitalization. Call your provider if you experience a burning feeling when urinating; a need to urinate often; lower stomach pain; blood in your urine; an odor from your genitals; or pain, itching, swelling, redness, or tenderness around your genitals.

Invokana (canagliflozin) can raise your risk for low blood sugar when taken together with certain other diabetes medications, such as insulin or sulfonylureas like glipizide. Very low blood sugar can be life-threatening. Symptoms of low blood sugar include being nervous or anxious; feeling shaky, sleepy, weak, or confused; having a fast heartbeat; sweating; and excessive hunger. Be sure to check your blood sugar if you experience any of these symptoms.

In some rare cases, Invokana (canagliflozin) can cause serious allergic reactions. If you experience a rash; trouble breathing; or swelling of your face, lips, tongue, or throat; get medical help right away.