Invokana Dosages for Adults: Your GoodRx Guide

Invokana (canagliflozin) is one of several sodium-glucose cotransporter-2 (SGLT2) inhibitors. When combined with a diabetes-friendly diet and regular exercise, it can help lower blood glucose (sugar) for adults with Type 2 diabetes. But Invokana can also lower the risk of heart and kidney problems for certain adults with diabetes.

As with every medication, taking the right dosage is key to getting the most out of your medication. Below, you’ll find everything you need to know about Invokana dosages, including when your healthcare provider may make adjustments.

What’s the typical Invokana dosage for adults?

Invokana comes as an oral tablet that you take by mouth once a day. These tablets are available as 100 mg and 300 mg doses.

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For all FDA-approved uses, the typical starting Invokana dosage is 100 mg before your first meal of the day. If this dosage isn’t working well enough to lower your blood glucose, your provider may raise your dosage to a maximum of 300 mg once a day.

Note: If you’re scheduled to have surgery that requires you to fast, you may need to temporarily stop Invokana. In these situations, your provider may ask you to stop taking it for at least 3 days and restart it once you’re done fasting. Make sure any surgeons caring for you are aware you take Invokana. They can tell you if or when you should stop and restart the medication.

Are there any dosage adjustments for health conditions?

Yes. There are times when your healthcare provider may adjust your Invokana dosage. These situations include if you have kidney problems or if you take certain medications that interact with Invokana.

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People with kidney problems

Invokana dosages for people with kidney problems are based on a blood test called estimated glomerular filtration rate (eGFR). Your provider will be in charge of determining your eGFR. The recommended dosages for various eGFR ranges are as follows:

• eGFR of 60 mL/min or greater: Follow the typical Invokana dosage instructions.

• eGFR of 30 to 59 mL/min: Take a maximum of 100 mg once a day.

• eGFR of less than 30 mL/min: Don’t start Invokana. If you’re already taking Invokana and your eGFR drops below 30 mL/min, you can take up to 100 mg once a day for heart or kidney protection.

Lower doses are recommended in cases like these because Invokana works mainly in your kidneys. People with kidney problems have a higher risk of certain side effects, such as low blood pressure, when taking dosages of 300 mg per day. This dosage is also less effective for lowering blood glucose for people with kidney problems.

People taking certain medications that interact with Invokana

Invokana interacts with a number of medications. Some interacting medications can speed up how quickly the body breaks down Invokana. This can lead to lower levels of Invokana in your body, making it less effective.

If you take one of these medications, you’ll likely take at least 200 mg of Invokana once a day. If your eGFR is at least 60 mL/min, you can take up to 300 mg per day if needed for better blood glucose balance.

Examples of interacting medications that require an Invokana dosage change include:

• Rifampin (Rifadin)

• Phenytoin (Dilantin)

• Phenobarbital

• Ritonavir (Norvir), or medications that contain it, such as Kaletra (lopinavir / ritonavir)

This isn’t a complete list of all Invokana interactions. You should share an updated list of your medications and supplements you take with your provider and pharmacist. This can help them determine if your Invokana dosage should be changed.

What happens if you miss a dose of Invokana?

If you miss a dose of Invokana, take it as soon as you remember. If it’s close to your next scheduled dose, then just skip it. Take your next dose at its usual time. Don't take two doses of Invokana at the same time to try to correct a missed dose. Doing so can cause more side effects.

If it’s later in the day when you remember a missed dose, you may also want to skip it and wait for your next dose. Invokana can cause you to urinate more often during the hours after a dose. Taking it in the evening may cause you to wake up while sleeping overnight to use the bathroom.

If you find it tough to remember to take your Invokana doses on time, there are many tips you can try to help trigger your memory. A medication reminder app is a great tool that can help keep you on track. Many free options are available. Your pharmacist is an excellent resource for other ways to help remember your medications.

What should you do if you take too much Invokana?

If you accidentally take an extra dose of Invokana by mistake, don’t fret. This is unlikely to cause serious harm. But you may notice more side effects than usual. Most commonly, you might have to urinate more often. In severe cases, you could become dehydrated. If you notice dizziness or lightheadedness after taking too much Invokana, contact your healthcare provider.

Invokana has a low risk of hypoglycemia (low blood glucose). But taking too much Invokana may raise your risk for this side effect. This is especially true if you take other diabetes medications, such as insulin. It’s important to treat hypoglycemia quickly if it happens to you. Untreated or severe hypoglycemia can be dangerous.

If you've taken too much Invokana, it’s a good idea to contact your provider, even if you’re not having any symptoms. You can also contact Poison Control online or at 1-800-222-1222 for guidance. If any side effects seem severe or life-threatening, call 911 or go to your nearest ER.

How to save on Invokana

There are ways to save on Invokana, which is only available as a brand-name medication. GoodRx can help you navigate between copay savings cards and patient assistance programs to save money on your prescription.

• Save with a copay savings card. If you have commercial insurance, you may be eligible to pay as little as $0 per month for Invokana using a savings card from the manufacturer.

• Save with patient assistance programs. If you’re uninsured, you may be eligible for Invokana’s patient assistance program, which offers the medication free of cost.

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Written by:

Timothy Aungst, PharmD

Timothy Aungst, PharmD, has worked in pharmacy practice for the past decade with different roles and responsibilities. He has served as an associate professor of pharmacy practice for almost a decade, a clinical pharmacist in outpatient cardiology management, and now in home healthcare.

Edited by:

Christina Aungst, PharmD

Christina Aungst, PharmD, is a pharmacy editor for GoodRx. She began writing for GoodRx Health in 2019, transitioning from freelance writer to editor in 2021.

Reviewed by:

Joshua Murdock, PharmD, BCBBS

Joshua Murdock, PharmD, BCBBS, is a licensed pharmacist in Arizona, Colorado, and Rhode Island. He has worked in the pharmacy industry for more than 10 years and currently serves as a pharmacy editor for GoodRx.

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