Sulfonylureas are used to treat Type 2 diabetes. They work by stimulating your pancreas to release more insulin, which helps lower your blood glucose (sugar). Sulfonylureas are available as oral tablets. Examples include glipizide (Glucotrol XL), glimepiride (Amaryl), and glyburide (Glynase, DiaBeta). You can discuss with your healthcare team which option might be right for you.