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Compare Jardiance vs. Glipizide

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Empagliflozin (Jardiance) and glipizide (Glucotrol XL) are both oral medications used to treat Type 2 diabetes. However, they belong to different medication classes and work in distinct ways. Empagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor that helps lower blood sugar by preventing sugar reabsorption in the kidneys, while glipizide is a sulfonylurea that stimulates the pancreas to release more insulin. Empagliflozin is also FDA-approved to reduce the risk of heart-related complications and worsening kidney problems in certain adults, whereas glipizide is only approved for Type 2 diabetes. Empagliflozin is typically taken once daily in the morning, while glipizide can be taken once or twice daily, depending on the formulation. Empagliflozin does not have a generic version available, while glipizide is available as a lower-cost generic. Common side effects of empagliflozin include urinary tract infections, yeast infections, and increased urination, whereas glipizide can cause low blood sugar and weight gain. Both medications have a risk of low blood sugar, and the risk is higher when combined with other diabetes medications.

  • Jardiance (empagliflozin)
    Glipizide
  • Jardiance (empagliflozin)
    Glipizide

  • Summary of Jardiance vs. Glipizide

    Summary for SGLT2 inhibitor
    Prescription only

    Jardiance (empagliflozin) is a brand-name medication that's used along with a nutritious diet and routine exercise to improve blood sugar levels in people 10 years and older with Type 2 diabetes. It can also lower the chance of serious complications, hospitalization, and death in certain adults with heart failure or chronic kidney disease (CKD). Jardiance (empagliflozin) belongs to the drug class called sodium-glucose cotransporter 2 (SGLT2) inhibitors. It's a tablet that's taken by mouth once a day. Side effects can include urinary tract infections (UTIs), yeast infections, and weight loss.

    Summary for Sulfonylurea
    Prescription only

    Glipizide is a sulfonylurea medication used to treat Type 2 diabetes in adults. It lowers blood sugar levels by telling your pancreas to release more insulin. Glipizide is taken by mouth, typically once or twice daily. Some side effects of this medication include dizziness and diarrhea. Taking glipizide can also put you at risk for dangerously low blood sugar, so it's important to take this medication with meals.

  • Indications of Jardiance vs. Glipizide

    Indications for
    •Type 2 diabetes (in addition to diet and exercise) in people age 10 years and older
    •Lowering the risk of death due to heart problems in adults with Type 2 diabetes and heart disease
    •Lowering the risk of hospitalization and death due to heart problems in adults with heart failure
    •Lowering the risk of worsening kidney problems, hospitalization, and death due to heart problems in adults with chronic kidney disease (CKD)
    Indications for
    •Type 2 diabetes

  • Pros and Cons of Jardiance vs. Glipizide

    Pros and Const for SGLT2 inhibitor
    Pros
    •Taken by mouth once a day
    •Unlikely to cause weight gain
    •Can take with other diabetes medications
    Cons
    •Raises risk of urinary tract infections (UTIs) and genital yeast infections
    •Might make you urinate more
    •Not recommended during the second and third trimesters of pregnancy
    Pros and Const for Sulfonylurea
    Pros
    •Taken by mouth
    •Extended-release tablets taken once daily
    •Available as a lower-cost generic medication
    Cons
    •Raises your risk for low blood sugar levels (hypoglycemia)
    •Need to take with meals or 30 minutes before a meal
    •Can cause some weight gain as a side effect

  • Common Side Effects of Jardiance vs. Glipizide

    Common Side Effects for
    •Urinary tract infection (UTI; 8-9%)
    •Vaginal yeast infection in females (5-6%)
    •Upper respiratory tract infection (3-4%)
    •High cholesterol or fat levels (3-4%)
    •Urinating more than usual (3%)
    Common Side Effects for
    •Dizziness (7%)
    •Diarrhea (5%)
    •Nervousness (4%)
    •Tremor (4%)
    •Passing gas (3%)
    •Low blood sugar levels (3%)

    Note: Side effects were reported by people who took glipizide ER (Glucotrol XL) in clinical studies.

  • Warnings of Jardiance vs. Glipizide

    Common Side Effects for
    •Ketoacidosis
    •Low fluids in the body (leading to low blood pressure or dehydration)
    •Genital and urinary tract infections
    •Low blood sugar (hypoglycemia) when used with certain other diabetes medications
    •Leg and foot amputations
    •Allergic reactions
    Common Side Effects for
    •Low blood sugar levels
    •Risk of low red blood cell count (hemolytic anemia)
    •Possible risk of serious heart problems
    •Risk of harm in people with certain stomach problems (extended-release tablets)

  • Prices with our coupons for Jardiance vs. Glipizide

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    Learn more about Glipizide

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