provider image
Welcome! You’re in GoodRx for healthcare professionals. Now, you’ll enjoy a streamlined experience created specifically for healthcare professionals.
Skip to main content
Glyburide Coupon - Glyburide 5mg tablet

glyburide

Generic Diabeta
Used for Diabetes Type 2
Used for Diabetes Type 2

Glyburide is taken by mouth to lower blood sugar levels for people who have Type 2 diabetes. This medication isn't meant to be taken alone, but in addition to eating a healthy diet and engaging in regular exercise. Glyburide is typically taken once or twice daily, depending on your dose.

Reviewed by:
reviewer
Allison Gourley, PharmD
reviewer
Kristianne Hannemann, PharmD
Last reviewed on February 28, 2023
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Glyburide?

What is Glyburide used for?

  • Type 2 diabetes

How Glyburide works

Glyburide is in a class of medications known as sulfonylureas. Sulfonylureas work by telling your pancreas to release insulin, which lowers your blood sugar.

Are you looking for information on glyburide / metformin tablets instead?

Drug Facts

Common BrandsGlynase
Drug ClassSulfonylurea
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
coupon-save-icon

Get your GoodRx coupon

Avg retail price
$36.81(save 85.12%)
GoodRx discount
$5.48
See prices
basics-icon

What are the side effects of Glyburide?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Feeling bloated
  • Nausea
  • Heartburn

Other Side Effects

  • Weight gain
  • Temporary allergic skin reactions, such as rash and redness

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Severe low blood sugar: anxiety, sweating, shaking, confusion, dizziness, weakness, fast heartbeat, feeling hungry, seizures

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Difficulty with swallowing

dizziness

fast heartbeat

hives, itching, skin rash

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

tightness in the chest

trouble breathing

unusual tiredness or weakness

Rare

Abdominal or stomach pain

chills

clay-colored stools

dark urine

diarrhea

fever

headache

light-colored stools

loss of appetite

nausea and vomiting

unpleasant breath odor

upper right abdominal or stomach pain

vomiting of blood

yellow eyes and skin

Incidence not known

Agitation

back, leg, or stomach pains

bleeding gums

blood in the urine or stools

bloody, black, or tarry stools

blurred vision

change in near or distance vision

chest pain

coma

confusion

convulsions

cough or hoarseness

decreased urine output

depression

difficulty in focusing eyes

fast or irregular heartbeat

fluid-filled skin blisters

general body swelling

high fever

hostility

increased thirst

irritability

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

lethargy

lower back or side pain

muscle pain or cramps

muscle twitching

nosebleeds

painful or difficult urination

pale skin

pinpoint red spots on the skin

rapid weight gain

sensitivity to the sun

skin thinness

sore throat

sores, ulcers, or white spots on the lips or in the mouth

stupor

swelling of the face, ankles, or hands

swollen or painful glands

unusual bleeding or bruising

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Anxiety

cold sweats

cool, pale skin

increased hunger

nervousness

nightmares

shakiness

slurred speech

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Indigestion

passing of gas

Incidence not known

Difficulty with moving

joint pain

redness or other discoloration of the skin

severe sunburn

swollen joints

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Glyburide

thumbs-up

Pros

Usually taken only once daily with largest meal

Can lower A1C levels by 1.5%

Taken by mouth, so good option for people who don't like injections

Can be taken with some other blood sugar medications, such as metformin

thumbs-down

Cons

Risk of low blood sugar (hypoglycemia), especially if you have kidney or liver problems

More likely to cause low blood sugar than other blood sugar medications, such as metformin

Can cause some weight gain

Not approved for Type 1 diabetes

pharmacist-tips

Pharmacist tips for Glyburide

pharmacist

  • Take glyburide with your first big meal of the day. It's important that you take this medication with food. Having an empty stomach and taking glyburide can cause your blood sugar to become too low. Talk to your provider or pharmacist if you're unsure about when to take or skip your medication.

    • Glyburide can commonly cause your blood sugar to get too low. Symptoms of low blood sugar include feeling shaky, being nervous or anxious, fast heartbeat, sweating or body chills, confusion, feeling sleepy, weakness or low energy, or feeling very hungry. If you experience these symptoms, test your blood sugar right away.

      • If your blood sugar ever becomes too low (between 50 mg/dL and 70 mg/dL), then it's important that you eat 15 grams of fast-acting sugar to bring your blood sugar back above 70 mg/dL. Some examples of fast-acting sugar include: 4 glucose (sugar) tablets, 3-4 pieces of hard candy, one-half cup of fruit juice, or one-half can of regular soda. After eating 15 grams of fast-acting sugar, wait 15 minutes and recheck your blood sugar. If it's still below 70 mg/dL then eat another 15 grams of carbohydrates and call 911. Recheck your blood sugar levels again in 15 minutes while you wait for help to arrive.

        • Glyburide can cause dizziness, so avoid activities that require coordination until you get used to the medication.

          • Make sure to check your blood sugar regularly, and report changes to your provider. Depending on your blood sugar readings, your provider might need to adjust your dose of glyburide.

            faqs

            Frequently asked questions about Glyburide

            What happens if I take glyburide and skip my meal?
            If you take glyburide and skip your meal, then your blood sugar level can drop too low. If this happens, you might experience symptoms such as dizziness, confusion, and shakiness. If you skip your largest meal of the day when you normally take your medication, your provider might recommend you also skip glyburide. To be safe, keep some fast-acting sugars with you so that you can raise your blood sugar level if it drops too low. Talk to your provider if you're unsure about when to take or skip your medication.
            Is glyburide safe to take during pregnancy?
            Glyburide hasn't been well-studied in human pregnancy, so it's not known whether this medication will cause harm to unborn babies. But there have been reports of babies experiencing seriously low blood sugar levels during delivery. If you're pregnant or thinking about becoming pregnant, talk with your provider about what medication options are best for you. Typically, insulin is the preferred medication to lower blood sugar levels during pregnancy, but it might not be appropriate for everyone.
            Can I take glyburide and metformin together?
            Yes, it's common for people to be taking both metformin and glyburide to lower their blood sugar if they have Type 2 diabetes. There's actually a combination medication that contains both metformin and glyburide together in one pill.
            How is micronized glyburide (Glynase) different from glyburide?
            Micronized glyburide (Glynase) and glyburide both contain the same medication, but in slightly different forms. Glyburide contains the non-micronized version of glyburide, whereas Glynase contains the micronized version of glyburide. The difference between the non-micronized and micronized medication has to do with how it's absorbed by your body. Micronized glyburide (Glynase) contains smaller particles that allow the medication to be absorbed better by the body which means, lower doses can be used compared to non-micronized glyburide. Keep in mind that the brand name version of the non-micronized glyburide (Diabeta) is no longer available, but there are generic versions that you might be able to take in its place. Ask your provider if you've more questions about the different formulations of glyburide.
            Can I take glyburide if I have Type 1 diabetes?
            No. Glyburide is only FDA-approved for people with Type 2 diabetes. This medication works by telling your body to make more insulin. People with Type 1 diabetes can't produce insulin very well, so for this reason, glyburide won't work for them.
            GoodRxEducationalIcon

            How to save using GoodRx

            Compare Prices
            1. Compare PricesSpecify your dosage and quantity to find out exactly how much you can save.
            Select your free coupon
            2. Select your free couponYou can use the displayed coupon, or compare prices at other pharmacies near you.
            Show coupon to your pharmacist
            3. Show coupon to your pharmacistPresent your printed or electronic coupon when you pick up your prescription.
            Get free couponLearn more
            warings-icon

            What are the risks and warnings for Glyburide?

            Glyburide can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

            risk-warning

            Low blood sugar (hypoglycemia)

            • Risk factors: Changes in diet and exercise | Drinking alcohol | Taking other medications that lower blood sugar | Age 65 years and older | Liver or kidney problems

              Glyburide can lower your blood sugar to dangerously low levels, which can be life-threatening. Signs of low blood sugar include fast heartbeat, sweating, pale skin, shakiness, confusion, and irritability. Make sure to carry with you some form of fast-acting sugar at all times you're taking this medication because you can use these to raise your blood sugar if it becomes too low. Some examples of fast-acting sugars include: 4 glucose (sugar) tablets, 3-4 pieces of hard candy, one-half cup of fruit juice, or one-half can of regular soda. Talk to your provider or pharmacist if you have questions about this.

              risk-warning

              Possible risk of heart problems

              There's a possibility that taking glyburide might raise the risk of death from heart problems. This specific warning was given about a medication called tolbutamide, which is in the same class (sulfonylureas) as glyburide. This means that other medications in the same class, like glyburide, might have the same risk for heart problems. Talk to your provider about the benefits and risks of taking glyburide to decide if it's the right medication for you.

              risk-warning

              Breakdown of red blood cells

              Before taking glyburide, your healthcare provider might test you for a genetic condition called glucose-6-phosphate dehydrogenase (G6PD) deficiency. People with G6PD deficiency who take sulfonylureas like glyburide have a higher risk of low red blood cell counts (hemolytic anemia). This is when your red blood cells break down faster than your body is able to make new ones. You might be able to take glyburide with close monitoring of your blood cell counts through regular blood work. Stop the medication and let your provider know right away if you experience dark urine, tiredness, weakness, dizziness, or pale skin, as these can be signs of hemolytic anemia.

              dosage

              Glyburide dosage forms

              The average cost for 90 tablets of 5mg of Glyburide is $16.92 with a free GoodRx coupon. This is 54.04% off the average retail price of $36.81.
              tablet
              Tablet
              DosageQuantityPrice as low asPrice per unit
              1.25mg30 tablets$5.48$0.18
              2.5mg90 tablets$10.25$0.11
              5mg90 tablets$16.92$0.19

              Typical dosing for Glyburide

              • Glyburide: The usual starting dose is 2.5 mg to 5 mg by mouth once daily with breakfast or the first main meal. Your provider will work with you to adjust your dose weekly until your blood sugar level is the target range. The typical maintenance dose ranges from 1.25 mg to 20 mg by mouth, either once daily or divided into smaller doses and taken twice daily. The maximum daily dose is 20 mg.

              • Micronized glyburide (Glynase and its generic): The usual starting dose is 1.5 mg to 3 mg by mouth once daily with breakfast or the first main meal. Your provider will work with you to adjust your dose weekly until your blood sugar level is the target range. The typical maintenance dose ranges from 0.75 mg to 12 mg by mouth, either once daily or divided into smaller doses and taken twice daily. The maximum daily dose is 12 mg.

              interactions

              Interactions between Glyburide and other drugs

              Glyburide may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Glyburide. Please note that only the generic name of each medication is listed below.

              Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

              Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

              Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

              drug-cost

              How much does Glyburide cost?

              To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
              Glyburide (generic)
              GoodRx lowest price

              $5.48

              (save 85.12%)
              View prices & coupons
              contraindications-icon

              Glyburide contraindications

              Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Glyburide will not be safe for you to take.
              alternatives

              What are alternatives to Glyburide?

              There are a number of medications that your doctor can prescribe in place of Glyburide. Compare a few possible alternatives below.
              Glyburide
              Used for:

              • Type 2 diabetes

              $5.48 Lowest GoodRx priceView Prices
              Glimepiride (Amaryl)
              Used for:

              • Type 2 diabetes in adults

              $15.30 Lowest GoodRx priceView Prices
              Glipizide
              Used for:
              $12.95 Lowest GoodRx priceView Prices
              latest news

              What is the latest news about Glyburide?

              Glipizide and glyburide are both effective treatments for Type 2 diabetes. Review the differences between glyburide and glipizide and compare their effects here.

              Glipizide vs. Glyburide: 7 Ways These Sulfonylureas Compare for Type 2 Diabetes

              Glipizide and glyburide are both effective treatments for Type 2 diabetes. Review the differences between glyburide and glipizide and compare their effects here.
              Many diabetes drugs cause weight changes. But which drugs cause weight loss, and which cause weight gain? Here’s how metformin, Ozempic, and other meds affect your weight.

              Which Diabetes Medications Can Cause Weight Loss or Gain?

              Many diabetes drugs cause weight changes. But which drugs cause weight loss, and which cause weight gain? Here’s how metformin, Ozempic, and other meds affect your weight.
              Glyburide (Diabeta, Glynase) can be used in diabetes to regulate blood sugar levels. It can cause hypoglycemia and other side effects, such as nausea, weight gain, and sun sensitivity.

              8 Glyburide Side Effects and How to Manage Them

              Glyburide (Diabeta, Glynase) can be used in diabetes to regulate blood sugar levels. It can cause hypoglycemia and other side effects, such as nausea, weight gain, and sun sensitivity.
              No, metformin does not cause cancer. In fact, metformin may actually be protective against cancer. Here’s what experts have to say about the effects of metformin and the recall.

              Is Metformin Bad for You? 4 Facts to Know About Cancer, Kidney, and Liver Damage Risks

              No, metformin does not cause cancer. In fact, metformin may actually be protective against cancer. Here’s what experts have to say about the effects of metformin and the recall.
              Sulfa drugs can trigger an allergic reaction if you have a sulfa allergy. Here are medications to avoid plus others that might be safer for you.

              Allergic to Sulfa Drugs? Here Are Some Medications You Can Still Take

              Sulfa drugs can trigger an allergic reaction if you have a sulfa allergy. Here are medications to avoid plus others that might be safer for you.
              Learn about some of the most common medications used to treat heart failure, and which medications can worsen the condition — some are more common than you think.

              The Most Common Medications for Heart Failure (and Ones That Make Heart Failure Worse)

              Learn about some of the most common medications used to treat heart failure, and which medications can worsen the condition — some are more common than you think.
              Oral diabetes medications help control blood sugar levels in those with diabetes. Learn the types of oral medications and how they keep glucose levels stable.

              8 Types of Oral Diabetes Medications and How They Work

              Oral diabetes medications help control blood sugar levels in those with diabetes. Learn the types of oral medications and how they keep glucose levels stable.
              Micronase and DiaBeta both belong to a class of medications that treat Type 2 diabetes. Find out which works best here.

              DiaBeta vs Micronase: What’s the Difference?

              Micronase and DiaBeta both belong to a class of medications that treat Type 2 diabetes. Find out which works best here.
              Sulfonylureas, such as glipizide and glyburide, are oral medications used to treat Type 2 diabetes. They help keep blood sugar levels under control by increasing the amount of insulin released by your pancreas.

              Sulfonylureas: 10 Things You Should Know About These Diabetes Medications

              Sulfonylureas, such as glipizide and glyburide, are oral medications used to treat Type 2 diabetes. They help keep blood sugar levels under control by increasing the amount of insulin released by your pancreas.
              From weight loss to cancer treatment, metformin can help in more ways than you think. Explore metformin benefits for fertility and more, at GoodRx.

              7 Metformin Benefits Beyond Diabetes Treatment

              From weight loss to cancer treatment, metformin can help in more ways than you think. Explore metformin benefits for fertility and more, at GoodRx.
              images

              Glyburide images

              Green Round N 344 And 5 - Glyburide 5mg Tablet
              This medicine is Green, Round, Scored Tablet Imprinted With "5" And "N 344".Green Round N 344 And 5 - Glyburide 5mg Tablet
              Green Round N 344 And 5 - Glyburide 5mg Tablet
              This medicine is Green, Round, Scored Tablet Imprinted With "5" And "N 344".Green Round N 344 And 5 - Glyburide 5mg Tablet
              Blue Oblong Glybur And 364 364 - Glyburide 5mg Tablet
              This medicine is Blue, Oblong, Scored Tablet Imprinted With "364 364" And "Glybur".Blue Oblong Glybur And 364 364 - Glyburide 5mg Tablet
              Green Round Cor 125 And Gg 240 - Glyburide 5mg Tablet
              This medicine is Green, Round, Scored Tablet Imprinted With "Cor 125" And "Gg 240".Green Round Cor 125 And Gg 240 - Glyburide 5mg Tablet
              Blue Oblong I 37 - Glyburide 5mg Tablet
              This medicine is Blue, Oblong, Scored Tablet Imprinted With "I 37".Blue Oblong I 37 - Glyburide 5mg Tablet
              Green Round C 11 - Glyburide 5mg Tablet
              This medicine is Green, Round, Scored Tablet Imprinted With "C 11".Green Round C 11 - Glyburide 5mg Tablet
              Green Round C 11 - Glyburide 5mg Tablet
              This medicine is Green, Round, Scored Tablet Imprinted With "C 11".Green Round C 11 - Glyburide 5mg Tablet
              Green Round C 11 - Glyburide 5mg Tablet
              This medicine is Green, Round, Scored Tablet Imprinted With "C 11".Green Round C 11 - Glyburide 5mg Tablet

              Get savings updates for Glyburide

              Receive price alerts, news, and other messages from GoodRx about Glyburide and other healthcare topics and relevant savings offers.

              By providing your email, you consent to receive marketing communications from GoodRx, which may include content and/or data related to men’s health, women's health, reproductive care, or sexual health. You agree to the GoodRx Terms of Use and acknowledge the Privacy Policy. You can unsubscribe at any time.

              References

              Best studies we found

              American Diabetes Association Professional Practice Committee. (2022). 15. Management of Diabetes in Pregnancy: Standards of Medical Care in Diabetes—2022. Diabetes Care.

              Cadila Pharmaceuticals Limited. (2022). GLYBURIDE tablet [package insert]. DailyMed.

              MedlinePlus. (2023). Glucose-6-phosphate dehydrogenase deficiency.

              View All References (5)

              MedlinePlus. (2018). Glyburide.

              Nathan, D. M., et al. (2009). Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care.

              National Heart, Lung, and Blood Institute. (2022). Hemolytic anemia.

              Pharmacia & Upjohn Company LLC. (2023). GLYNASE- glyburide tablet [package insert]. DailyMed.

              Teva Pharmaceuticals USA, Inc. (2023). GLYBURIDE tablet [package insert]. DailyMed.

              GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
              Was this page helpful?

              Compare other Diabetes Type 2 drugs

              Farxiga vs GlyburideGlucovance vs GlyburideGlyburide vs ActosGlyburide vs AfrezzaGlyburide vs ByettaGlyburide vs GlysetGlyburide vs JanumetHuman Insulin vs GlyburideInvokana vs GlyburideJardiance vs GlyburideMetaglip vs GlyburideNesina vs GlyburideOnglyza vs GlyburidePrandimet vs GlyburideStarlix vs GlyburideToujeo vs GlyburideBrenzavvy vs FarxigaEntresto vs FarxigaFarxiga vs ActosFarxiga vs AfrezzaMetaglip vs NesinaNesina vs ActosNesina vs AfrezzaNesina vs ByettaNesina vs GlucotrolNesina vs HumalogNesina vs JanuviaNesina vs MetforminNesina vs PrecoseOnglyza vs Nesina
              View More

              Browse medications

              View All

              Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.