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Compare Glyburide vs. Glyset

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Glyburide (Glynase) and Miglitol (Glyset) are both used to help manage blood sugar in people with Type 2 diabetes, but they some differences between them. Glyburide helps your pancreas release more insulin, while Miglitol slows the breakdown of carbohydrates to prevent high blood sugar after meals. Glyburide is usually taken once or twice daily with meals, unlike miglitol which is taken three times a day with meals. Glyburide can cause low blood sugar and weight gain, but miglitol does not cause these issues. However, miglitol can cause gas, diarrhea, and stomach pain, especially when you first start taking it. Both medications are only approved for use in people with type 2 diabetes, but unlike miglitol, glyburide isn't recommended for people who are pregnant.

  • Glyburide
    Miglitol
  • Glyburide
    Miglitol

  • Summary of Glyburide vs. Glyset

    Summary for Sulfonylurea
    Prescription only

    Glyburide is taken by mouth to lower blood sugar levels for people who have Type 2 diabetes. This medication isn't meant to be taken alone, but in addition to eating a healthy diet and engaging in regular exercise. Glyburide is typically taken once or twice daily, depending on your dose.

    Summary for Alpha-glucosidase inhibitor
    Prescription only

    Miglitol is a medication that's used together with diet and exercise to help control blood sugar in adults with Type 2 diabetes. This medication is taken by mouth, typically 3 times a day with the first few bites of each meal. Miglitol isn't as commonly used as other diabetes medications since it can lead to some unpleasant side effects like gas and diarrhea. But it's less likely to cause hypoglycemia when used on its own. It's only available as the generic name miglitol since the brand name Glyset is no longer available.

  • Indications of Glyburide vs. Glyset

    Indications for
    •Type 2 diabetes
    Indications for
    •Type 2 diabetes in adults

  • Pros and Cons of Glyburide vs. Glyset

    Pros and Const for Sulfonylurea
    Pros
    •Usually taken only once daily with largest meal
    •Can lower A1C levels by 1.5%
    •Taken by mouth, so good option for people who don't like injections
    •Can be taken with some other blood sugar medications, such as metformin
    Cons
    •Risk of low blood sugar (hypoglycemia), especially if you have kidney or liver problems
    •More likely to cause low blood sugar than other blood sugar medications, such as metformin
    •Can cause some weight gain
    •Not approved for Type 1 diabetes
    Pros and Const for Alpha-glucosidase inhibitor
    Pros
    •Not likely to cause weight gain, instead it might cause weight loss
    •Helps control blood sugar levels after each meal
    •Low risk of low blood sugar when used alone
    •Can be used with other diabetes medications
    Cons
    •Must be taken multiple times a day
    •Side effects include diarrhea, gas, and stomach pain
    •Not recommended for people with severe kidney problems
    •Typically not considered a first-choice treatment option

  • Common Side Effects of Glyburide vs. Glyset

    Common Side Effects for
    •Feeling bloated
    •Nausea
    •Heartburn
    Common Side Effects for
    •Passing gas (42%)
    •Diarrhea (29%)
    •Stomach pain (12%)

  • Warnings of Glyburide vs. Glyset

    Common Side Effects for
    •Low blood sugar (hypoglycemia)
    •Possible risk of heart problems
    •Breakdown of red blood cells
    Common Side Effects for
    •Low blood sugar when taken together with other diabetes medications
    •Kidney problems causing medication buildup
    •Losing control of blood sugar

  • Prices with our coupons for Glyburide vs. Glyset

    Learn more about Glyburide
    Learn more about Miglitol

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