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Glyburide vs. Miglitol

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Glyburide

 

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Miglitol

 

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Summary for Glyburide

Prescription only

Glyburide is taken by mouth to lower blood sugar levels for people who have Type 2 diabetes. This medication isn't meant to be taken alone, but in addition to eating a healthy diet and engaging in regular exercise. Glyburide is typically taken once or twice daily, depending on your dose.

Indications for Glyburide

  • Type 2 diabetes

Pros and Cons for Glyburide

Pros

  • Usually taken only once daily with largest meal
  • Can lower A1C levels by 1.5%
  • Taken by mouth, so good option for people who don't like injections
  • Can be taken with some other blood sugar medications, such as metformin

Cons

  • Risk of low blood sugar (hypoglycemia), especially if you have kidney or liver problems
  • More likely to cause low blood sugar than other blood sugar medications, such as metformin
  • Can cause some weight gain
  • Not approved for Type 1 diabetes

Common Side Effects for Glyburide

  • Feeling bloated
  • Nausea
  • Heartburn

Warnings for Glyburide

  • Low blood sugar (hypoglycemia)
  • Possible risk of heart problems
  • Breakdown of red blood cells

Summary for Miglitol

Prescription only

Miglitol is a medication that's used together with diet and exercise to help control blood sugar in adults with Type 2 diabetes. This medication is taken by mouth, typically 3 times a day with the first few bites of each meal. Miglitol isn't as commonly used as other diabetes medications since it can lead to some unpleasant side effects like gas and diarrhea. But it's less likely to cause hypoglycemia when used on its own. It's only available as the generic name miglitol since the brand name Glyset is no longer available.

Indications for Miglitol

Pros and Cons for Miglitol

Pros

  • Not likely to cause weight gain, instead it might cause weight loss
  • Helps control blood sugar levels after each meal
  • Low risk of low blood sugar when used alone
  • Can be used with other diabetes medications

Cons

  • Must be taken multiple times a day
  • Side effects include diarrhea, gas, and stomach pain
  • Not recommended for people with severe kidney problems
  • Typically not considered a first-choice treatment option

Common Side Effects for Miglitol

  • Passing gas (42%)
  • Diarrhea (29%)
  • Stomach pain (12%)

Warnings for Miglitol

  • Low blood sugar when taken together with other diabetes medications
  • Kidney problems causing medication buildup
  • Losing control of blood sugar

Prices with our coupons for Glyburide vs. Miglitol

Price Card Drug Icon
Glyburide180 tablets / 5mg
$18.28$107.54
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Price Card Drug Icon
Miglitol100 tablets / 25mg
$40.98-
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