Compare Onglyza vs. Glyburide

Saxagliptin (Onglyza) and glyburide (Glynase) are both medications used to manage Type 2 diabetes, but they work in different ways and have distinct characteristics. Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that helps your body keep insulin around longer, while glyburide is a sulfonylurea that prompts your pancreas to release more insulin. Saxagliptin is typically taken once daily and is less likely to cause weight gain or low blood sugar compared to glyburide. On the other hand, glyburide can be taken once or twice daily with meals and is known to lower A1C levels more significantly, but it carries a higher risk of causing low blood sugar and weight gain. Saxagliptin is available in generic form, while glyburide is available in both non-micronized and micronized forms, with the latter being absorbed better by the body. Both medications require a prescription and should be used alongside a healthy diet and regular exercise.