Head-to-head comparisons of medication uses, side effects, warnings, and more.
Januvia (sitagliptin)
Farxiga (dapagliflozin)
Januvia (sitagliptin)
Farxiga (dapagliflozin)
Summary of Januvia vs. Farxiga
Summary for DDP-4 inhibitor
Prescription only
Januvia (sitagliptin) is a prescription medication used along with a healthy diet and exercise to treat Type 2 diabetes. It belongs to the drug class dipeptidyl peptidase-4 (DPP-4) inhibitor, also known as gliptins. Januvia (sitagliptin) is taken by mouth, typically once daily. Most people don't experience many side effects from this medication, but possible ones include stuffy or runny nose, sore throat, and headache.
Summary for SGLT2 inhibitor
Prescription only
Farxiga, the brand name for dapagliflozin, is used together with a nutritious diet and exercise plan to lower blood sugar levels in people 10 years and older with Type 2 diabetes. It can also help lower the risk of serious complications, hospitalization, and death in certain adults with heart failure or chronic kidney disease (CKD). Farxiga (dapagliflozin) belongs to the drug class called sodium-glucose cotransporter 2 (SGLT2) inhibitors. It's taken by mouth once a day. Some side effects include yeast infections, urinating more often, and weight loss.
Indications of Januvia vs. Farxiga
Indications for
•Type 2 diabetes in adults
Indications for
•Type 2 diabetes (in addition to diet and exercise) in people age 10 and over
•Lowering the risk of hospitalization for heart failure in adults with Type 2 diabetes and heart disease
•Lowering the risk of hospitalization and death due to heart problems in people with heart failure
•Lowering the risk of worsening kidney problems, hospitalization for heart failure, and death due to heart problems in adults with chronic kidney disease (CKD)
Pros and Cons of Januvia vs. Farxiga
Pros and Const for DDP-4 inhibitor
Pros
•Only taken once a day
•Can take with or without food
•Not known to affect your body weight
Cons
•Can cause severe joint pain
•Not a first choice option for people with Type 2 diabetes and heart problems
•Might cause sudden kidney injury in people with kidney problems
Pros and Const for SGLT2 inhibitor
Pros
•Taken only once daily
•Low risk of causing low blood sugar when taken by itself