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Compare Januvia vs. Farxiga

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Sitagliptin (Januvia) and dapagliflozin (Farxiga) are both oral medications used to treat Type 2 diabetes, but they belong to different medication classes. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor, while dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. Sitagliptin is taken once daily at a dose of 25 mg to 100 mg, whereas dapagliflozin is started at 5 mg daily and can be increased to 10 mg daily. Dapagliflozin is also approved to lower the risk of heart failure hospitalization and to help with chronic kidney disease, which sitagliptin is not. While sitagliptin is not known to affect body weight, dapagliflozin may cause weight loss. Common side effects of sitagliptin include a runny nose and sore throat, while dapagliflozin can cause urinary tract infections, yeast infections, and increased urination. Both medications can interact with other diabetes treatments, potentially causing low blood sugar.

  • Januvia (sitagliptin)
    Farxiga (dapagliflozin)
  • Januvia (sitagliptin)
    Farxiga (dapagliflozin)

  • Summary of Januvia vs. Farxiga

    Summary for DDP-4 inhibitor
    Prescription only

    Januvia (sitagliptin) is a prescription medication that helps lower blood sugar in adults with Type 2 diabetes. It works best when you also follow a balanced diet and exercise regularly. It belongs to the drug class called dipeptidyl peptidase-4 (DPP-4) inhibitors, or gliptins. Januvia (sitagliptin) comes as a tablet you take by mouth once a day. Side effects include stuffy or runny nose and headache. Januvia (sitagliptin) is a brand-name medication only; the generic version isn't available yet.

    Summary for SGLT2 inhibitor
    Prescription only

    Farxiga, the brand name for dapagliflozin, is used together with a nutritious diet and exercise plan to lower blood sugar levels in people 10 years and older with Type 2 diabetes. It can also help lower the risk of serious complications, hospitalization, and death in certain adults with heart failure or chronic kidney disease (CKD). Farxiga (dapagliflozin) belongs to the drug class called sodium-glucose cotransporter 2 (SGLT2) inhibitors. It's taken by mouth once a day. Some side effects include yeast infections, urinating more often, and weight loss.

  • Indications of Januvia vs. Farxiga

    Indications for
    •Type 2 diabetes in adults
    Indications for
    •Type 2 diabetes (in addition to diet and exercise) in people age 10 and over
    •Lowering the risk of hospitalization for heart failure in adults with Type 2 diabetes and heart disease
    •Lowering the risk of hospitalization and death due to heart problems in people with heart failure
    •Lowering the risk of worsening kidney problems, hospitalization for heart failure, and death due to heart problems in adults with chronic kidney disease (CKD)

  • Pros and Cons of Januvia vs. Farxiga

    Pros and Const for DDP-4 inhibitor
    Pros
    •Taken once a day
    •Not likely to affect your body weight
    Cons
    •Not for people with Type 1 diabetes
    •Possible risk of severe joint pain
    Pros and Const for SGLT2 inhibitor
    Pros
    •Taken only once daily
    •Low risk of causing low blood sugar when taken by itself
    •Can take with other diabetes medications
    Cons
    •Raises risk of yeast infections and urinary tract infections (UTIs)
    •Not available as a liquid
    •Not recommended during the second and third trimesters of pregnancy

  • Common Side Effects of Januvia vs. Farxiga

    Common Side Effects for
    •Runny or stuffy nose and other symptoms of the common cold (5%)
    Common Side Effects for
    •Vaginal yeast infection in females (7-8%)
    •Nose and throat infection (6-7%)
    •Urinary tract infection (UTI, 4-6%)

  • Warnings of Januvia vs. Farxiga

    Common Side Effects for
    •Inflammation of the pancreas (pancreatitis)
    •Risk of heart failure
    •Sudden kidney problems
    •Low blood sugar when taken with other diabetes medications
    •Serious allergic reactions
    •Joint pain
    •Severe skin reactions
    Common Side Effects for
    •Ketoacidosis
    •Low fluids in the body (leading to low blood pressure or dehydration)
    •Genital and urinary tract infections
    •Low blood sugar (hypoglycemia) when used with other diabetes medications

  • Prices with our coupons for Januvia vs. Farxiga

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