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Glyxambi vs. Januvia

Glyxambi (empagliflozin / linagliptin) is used to manage blood sugar levels in adults with Type 2 diabetes. It's a combination of 2 medications: empagliflozin (a sodium-glucose co-transporter 2 (SGLT2) inhibitor) and linagliptin (a dipeptidyl peptidase-4 (DPP-4) inhibitor). It lowers blood sugar by getting rid of extra sugar through your urine and helping your body make more insulin. Glyxambi (empagliflozin / linagliptin) is taken by mouth once daily. Some common side effects include urinary tract infections and upper respiratory tract infections.

• Type 2 diabetes in adults (when taken along with nutritious diet and regular exercise)
• Lowers risk of death from heart problems in adults with Type 2 diabetes and heart disease

• Urinary tract infection (11-13%)
• Upper respiratory tract infection (7%)

• Pancreas problems
• Ketoacidosis (too much acid in the blood)
• Low fluids in the body (leading to low blood pressure or dehydration, or kidney problems)
• Low blood sugar with other diabetes medications
• Genital and urinary tract infections
• Serious allergic or skin reactions
• Joint pain
• Leg and foot amputations
• Heart failure

Januvia (sitagliptin) is a prescription medication that helps lower blood sugar in adults with Type 2 diabetes. It works best when you also follow a balanced diet and exercise regularly. It belongs to the drug class called dipeptidyl peptidase-4 (DPP-4) inhibitors, or gliptins. Januvia (sitagliptin) comes as a tablet you take by mouth once a day. Side effects include stuffy or runny nose and headache. Januvia (sitagliptin) is a brand-name medication only; the generic version isn't available yet.

• Type 2 diabetes in adults

• Runny or stuffy nose and other symptoms of the common cold (5%)

• Inflammation of the pancreas (pancreatitis)
• Risk of heart failure
• Sudden kidney problems
• Low blood sugar when taken with other diabetes medications
• Serious allergic reactions
• Joint pain
• Severe skin reactions