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Compare Metaglip vs. Nesina

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Glipizide/metformin (generic) and Alogliptin (Nesina) are both medications used to treat Type 2 diabetes, but they have some differences between them. Glipizide/metformin is a combination of two medications: glipizide, which stimulates insulin release, and metformin, which reduces sugar production and absorption. Alogliptin helps insulin stay in your body longer and reduces sugar production. Glipizide/metformin must be taken with meals to avoid low blood sugar, while alogliptin can be taken with or without food. Both are available as lower-cost generic medications. Alogliptin is not a first-choice treatment for Type 2 diabetes and is typically added to other medications, while metformin, part of the glipizide/metformin combination, is a first-choice treatment. Both medications can cause side effects, but glipizide/metformin can cause diarrhea and low blood sugar, while taking alogliptin can cause upper respiratory infections and headaches.

  • Glipizide/metformin
    Alogliptin (Nesina)
  • Glipizide/metformin
    Alogliptin (Nesina)

  • Summary of Metaglip vs. Nesina

    Summary for Sulfonylurea / Biguanide
    Prescription only

    Glipizide/metformin combines two diabetes medications into one tablet: glipizide (a sulfonylurea) and metformin (a biguanide). It's approved to treat Type 2 diabetes in adults along with diet and exercise. This medication is typically taken by mouth once or twice a day. Some common side effects of glipizide/metformin can include diarrhea and headache; it isn't likely to cause weight gain or weight loss.

    Summary for DDP-4 inhibitor
    Prescription only

    Alogliptin (Nesina) is a medication that treats Type 2 diabetes. It's added to diet and exercise to help lower your blood sugar levels. But it isn't a first-choice treatment for this condition. Alogliptin (Nesina) is typically taken by mouth once a day. Some people may experience certain side effects, such as headaches or symptoms of the common cold (e.g., sore throat or runny nose), after starting this medication.

  • Indications of Metaglip vs. Nesina

    Indications for
    •Type 2 diabetes
    Indications for
    •Type 2 diabetes

  • Pros and Cons of Metaglip vs. Nesina

    Pros and Const for Sulfonylurea / Biguanide
    Pros
    •Taken by mouth
    •Combination medication, so more convenient to take
    •Available as a lower-cost generic
    Cons
    •Need to take with meals
    •Can't take during pregnancy
    •Not an option for children
    Pros and Const for DDP-4 inhibitor
    Pros
    •Taken once daily by mouth
    •Can be taken with or without food
    •Is available as a lower-cost generic
    Cons
    •Dose may change if you have kidney problems, while other similar medications, like Tradjenta (linagliptin), don't need dose changes
    •Not a first-choice treatment for Type 2 diabetes
    •Isn’t approved for Type 1 diabetes

  • Common Side Effects of Metaglip vs. Nesina

    Common Side Effects for
    •Diarrhea (18%)
    •Headache (13%)
    •Cold or flu infection (10%)
    •Low blood sugar levels (9%)
    •Muscle pain (8%)
    •Nausea, vomiting (8%)
    •Stomach pain (6%)
    •Dizziness (5%)
    Common Side Effects for
    •Upper respiratory tract infection (5%)
    •Common cold (5%)
    •Headache (4%)

  • Warnings of Metaglip vs. Nesina

    Common Side Effects for
    •Lactic acidosis
    •Possible risk of serious heart problems
    •Low blood sugar levels
    •Low vitamin B12 levels
    Common Side Effects for
    •Heart failure
    •Severe joint pain
    •Inflammation of the pancreas
    •Liver problems
    •Severe itching rash

  • Prices with our coupons for Metaglip vs. Nesina

    Learn more about Glipizide/metformin
    Learn more about Alogliptin

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