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Compare Glyxambi vs. Metformin

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Glyxambi (empagliflozin / linagliptin)
    Metformin
  • Glyxambi (empagliflozin / linagliptin)
    Metformin

  • Summary of Glyxambi vs. Metformin

    Summary for SGLT2 inhibitor / DPP-4 inhibitor
    Prescription only

    Glyxambi (empagliflozin / linagliptin) is used to manage blood sugar levels in adults with Type 2 diabetes. It's a combination of 2 medications: empagliflozin (a sodium-glucose co-transporter 2 (SGLT2) inhibitor) and linagliptin (a dipeptidyl peptidase-4 (DPP-4) inhibitor). It lowers blood sugar by getting rid of extra sugar through your urine and helping your body make more insulin. Glyxambi (empagliflozin / linagliptin) is taken by mouth once daily. Some common side effects include urinary tract infections and upper respiratory tract infections.

    Summary for Biguanide
    Prescription only

    Immediate-release metformin is an oral diabetes medication. It's approved for people 10 years of age and older with Type 2 diabetes. The medication belongs to the drug class called biguanides. It works best to lower blood sugar levels with a diabetes-friendly diet and exercise plan. Immediate-release metformin comes as a tablet and an oral solution. You take this medication by mouth usually two to three times a day. It's recommended to take each dosage with food to help lessen side effects like diarrhea and nausea.

  • Indications of Glyxambi vs. Metformin

    Indications for
    •Type 2 diabetes in adults (when taken along with nutritious diet and regular exercise)
    •Lowers risk of death from heart problems in adults with Type 2 diabetes and heart disease
    Indications for
    •Type 2 diabetes in people ages 10 years and older

  • Pros and Cons of Glyxambi vs. Metformin

    Pros and Const for SGLT2 inhibitor / DPP-4 inhibitor
    Pros
    •Combines two medications into one pill for convenience
    •Can lower the risk of death from heart attack or stroke in people with Type 2 diabetes and heart disease
    •Only taken once a day in the morning with or without food
    •Not likely to cause weight gain
    Cons
    •Not safe for use in people on dialysis
    •Not approved for people with Type 1 diabetes
    •Might cause you to urinate more often
    •Might cause urinary tract infections or genital yeast infections
    Pros and Const for Biguanide
    Pros
    •One of the first-choice options for Type 2 diabetes
    •Works well at lowering blood sugar levels (can lower your A1C by up to 1.5% in a few months)
    •Unlikely to cause weight gain
    •Available as a liquid for people who have trouble swallowing tablets
    Cons
    •Typically need to take a couple times per day
    •Can cause stomach upset, including diarrhea, nausea, gas, and stomach cramping
    •Not a good choice for people with severe kidney problems
    •Not recommended for people with liver problems

  • Common Side Effects of Glyxambi vs. Metformin

    Common Side Effects for
    •Urinary tract infection (11-13%)
    •Upper respiratory tract infection (7%)
    Common Side Effects for
    •Diarrhea (53%)
    •Nausea or vomiting (26%)
    •Gas (12%)
    •Weakness (9%)

  • Warnings of Glyxambi vs. Metformin

    Common Side Effects for
    •Pancreas problems
    •Ketoacidosis (too much acid in the blood)
    •Low fluids in the body (leading to low blood pressure or dehydration, or kidney problems)
    •Low blood sugar with other diabetes medications
    •Genital and urinary tract infections
    •Serious allergic or skin reactions
    •Joint pain
    •Leg and foot amputations
    •Heart failure
    Common Side Effects for
    •Lactic acidosis
    •Low vitamin B12 levels
    •Low blood sugar (hypoglycemia) when taken with certain other diabetes medications

  • Prices with our coupons for Glyxambi vs. Metformin

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    Learn more about Metformin

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