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Compare Glucovance vs. Glyxambi

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Glucovance (glyburide/metformin) and Glyxambi (empagliflozin/linagliptin) are medications used to treat Type 2 diabetes. Both are combination medications, but they several differences between them. Glucovance combines glyburide and metformin to lower blood sugar by stimulating insulin release and reducing sugar production and absorption. It's best taken with meals to avoid low blood sugar and stomach upset. Glyxambi, on the other hand, combines empagliflozin and linagliptin to lower blood sugar by preventing sugar reabsorption in the kidneys and increasing insulin production. Glyxambi is taken once daily and can also reduce the risk of death from heart disease in people with Type 2 diabetes. Unlike Glyxambi, Glucovance is available as a lower-cost generic. Both medications have serious side effects, but Glucovance has a higher risk of causing low blood sugar, whereas Glyxambi can lead to urinary tract infections and dehydration.

  • Glyburide/metformin
    Glyxambi (empagliflozin / linagliptin)
  • Glyburide/metformin
    Glyxambi (empagliflozin / linagliptin)

  • Summary of Glucovance vs. Glyxambi

    Summary for Sulfonylurea / Biguanide
    Prescription only

    Glyburide/metformin is used to manage blood sugar levels in adults with Type 2 diabetes. It works best when taken with a healthy diet and regular exercise. This medication combines a sulfonylurea (glyburide) and a biguanide (metformin). You take it by mouth, typically once or twice daily with meals. Since glyburide/metformin can cause hypoglycemia (low blood sugar), it's important to carry fast-acting sugars like gummy candy or fruit juice to quickly raise your blood sugar if needed. Other common side effects include diarrhea, headache, and nausea. Brand name Glucovance has been discontinued.

    Summary for SGLT2 inhibitor / DPP-4 inhibitor
    Prescription only

    Glyxambi (empagliflozin / linagliptin) is used to manage blood sugar levels in adults with Type 2 diabetes. It's a combination of 2 medications: empagliflozin (a sodium-glucose co-transporter 2 (SGLT2) inhibitor) and linagliptin (a dipeptidyl peptidase-4 (DPP-4) inhibitor). It lowers blood sugar by getting rid of extra sugar through your urine and helping your body make more insulin. Glyxambi (empagliflozin / linagliptin) is taken by mouth once daily. Some common side effects include urinary tract infections and upper respiratory tract infections.

  • Indications of Glucovance vs. Glyxambi

    Indications for
    •Type 2 diabetes (T2D) in adults
    Indications for
    •Type 2 diabetes in adults (when taken along with nutritious diet and regular exercise)
    •Lowers risk of death from heart problems in adults with Type 2 diabetes and heart disease

  • Pros and Cons of Glucovance vs. Glyxambi

    Pros and Const for Sulfonylurea / Biguanide
    Pros
    •Combines two medications into one pill for convenience
    •Dose can be adjusted if needed
    •Taken by mouth instead of an injection
    Cons
    •Need to take with meals
    •Not safe for use in people with moderate-to-severe kidney disease
    •More likely to cause weight gain compared to some other medications for diabetes
    Pros and Const for SGLT2 inhibitor / DPP-4 inhibitor
    Pros
    •Combines two medications into one pill for convenience
    •Can lower the risk of death from heart attack or stroke in people with Type 2 diabetes and heart disease
    •Only taken once a day in the morning with or without food
    •Not likely to cause weight gain
    Cons
    •Not safe for use in people on dialysis
    •Not approved for people with Type 1 diabetes
    •Might cause you to urinate more often
    •Might cause urinary tract infections or genital yeast infections

  • Common Side Effects of Glucovance vs. Glyxambi

    Common Side Effects for
    •Low blood sugar levels (up to 38%)
    •Diarrhea (17%)
    •Headache (9%)
    •Nausea or vomiting (8%)
    •Belly pain (7%)
    •Dizziness (6%)
    Common Side Effects for
    •Urinary tract infection (11-13%)
    •Upper respiratory tract infection (7%)

  • Warnings of Glucovance vs. Glyxambi

    Common Side Effects for
    •Lactic acidosis (too much acid in your body)
    •Low blood sugar
    •Possible risk of serious heart problems
    •Risk of low red blood cell count (hemolytic anemia)
    •Low vitamin B12 levels
    Common Side Effects for
    •Pancreas problems
    •Ketoacidosis (too much acid in the blood)
    •Low fluids in the body (leading to low blood pressure or dehydration, or kidney problems)
    •Low blood sugar with other diabetes medications
    •Genital and urinary tract infections
    •Serious allergic or skin reactions
    •Joint pain
    •Leg and foot amputations
    •Heart failure

  • Prices with our coupons for Glucovance vs. Glyxambi

    Learn more about Glyburide/metformin
    Learn more about Glyxambi

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