Key takeaways
Glucovance (glyburide/metformin) and Glyxambi (empagliflozin/linagliptin) are medications used to treat Type 2 diabetes. Both are combination medications, but they several differences between them. Glucovance combines glyburide and metformin to lower blood sugar by stimulating insulin release and reducing sugar production and absorption. It's best taken with meals to avoid low blood sugar and stomach upset. Glyxambi, on the other hand, combines empagliflozin and linagliptin to lower blood sugar by preventing sugar reabsorption in the kidneys and increasing insulin production. Glyxambi is taken once daily and can also reduce the risk of death from heart disease in people with Type 2 diabetes. Unlike Glyxambi, Glucovance is available as a lower-cost generic. Both medications have serious side effects, but Glucovance has a higher risk of causing low blood sugar, whereas Glyxambi can lead to urinary tract infections and dehydration.
