Key takeaways
Humulin R (insulin regular) and Actos (pioglitazone) are both used to manage diabetes, but they belong to different medication classes and work in different ways. Humulin R is a short-acting insulin that helps control blood sugar by allowing your body to absorb and store sugar after meals. It is available in two strengths, U-100 and U-500, and is typically injected under the skin multiple times a day. Actos, on the other hand, is a thiazolidinedione taken orally once a day. It helps your body respond better to insulin and lowers the amount of sugar your liver makes. While Humulin R can be used for both Type 1 and Type 2 diabetes, Actos is only approved for Type 2 diabetes. Humulin R is available over the counter in its U-100 form, whereas Actos requires a prescription. Common side effects of Humulin R include low blood sugar and injection site reactions, while Actos can cause weight gain, swelling, and may worsen heart failure. Additionally, Actos has a generic version available, which can be more cost-effective.
