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Compare Glucovance vs. Lantus

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Glucovance (glyburide/metformin) and Lantus (insulin glargine) are both used to manage diabetes, but they have several differences between them. Glucovance is a combination of two medications, glyburide and metformin, taken to help manage blood sugar in adults with type 2 diabetes. Glyburide stimulates the pancreas to release insulin, while metformin reduces sugar production in the liver and improves insulin sensitivity. On the other hand, Lantus is a long-acting insulin injected under the skin, used for type 1 and type 2 diabetes. It helps your body absorb and store sugar from the bloodstream and stops the liver from making glucose. Glucovance must be taken with meals to avoid low blood sugar and stomach upset, while Lantus can cause weight gain and low blood sugar.

  • Glyburide/metformin
    Lantus (insulin glargine)
  • Glyburide/metformin
    Lantus (insulin glargine)

  • Summary of Glucovance vs. Lantus

    Summary for Sulfonylurea / Biguanide
    Prescription only

    Glyburide/metformin is used to manage blood sugar levels in adults with Type 2 diabetes. It works best when taken with a healthy diet and regular exercise. This medication combines a sulfonylurea (glyburide) and a biguanide (metformin). You take it by mouth, typically once or twice daily with meals. Since glyburide/metformin can cause hypoglycemia (low blood sugar), it's important to carry fast-acting sugars like gummy candy or fruit juice to quickly raise your blood sugar if needed. Other common side effects include diarrhea, headache, and nausea. Brand name Glucovance has been discontinued.

    Summary for Insulin
    Prescription only

    Lantus (insulin glargine) is a long-acting insulin. It's used to manage blood sugar levels in adults and children with Type 1 diabetes or Type 2 diabetes. Lantus (insulin glargine) is injected under the skin, typically once daily or as directed by your healthcare team. Your care team will determine your dose of Lantus (insulin glargine) based on different factors, such as your diet and blood sugar levels. Lantus (insulin glargine) comes as a vial and a prefilled insulin pen (Lantus Solostar). Some side effects of this medication include redness and swelling at the injection site, and upper respiratory tract infections.

  • Indications of Glucovance vs. Lantus

    Indications for
    •Type 2 diabetes (T2D) in adults
    Indications for
    •Type 1 diabetes (T1D)
    •Type 2 diabetes (T2D)

  • Pros and Cons of Glucovance vs. Lantus

    Pros and Const for Sulfonylurea / Biguanide
    Pros
    •Combines two medications into one pill for convenience
    •Dose can be adjusted if needed
    •Taken by mouth instead of an injection
    Cons
    •Need to take with meals
    •Not safe for use in people with moderate-to-severe kidney disease
    •More likely to cause weight gain compared to some other medications for diabetes
    Pros and Const for Insulin
    Pros
    •Can control your blood sugar levels for about 24 hours
    •Typically injected once daily
    •Approved for children and adults
    •Available as a vial and pre-filled pen
    Cons
    •Given as an injection
    •Raises risk of dangerously low blood sugar levels
    •Might cause weight gain
    •Can't be mixed with other insulins within the same syringe

  • Common Side Effects of Glucovance vs. Lantus

    Common Side Effects for
    •Low blood sugar levels (up to 38%)
    •Diarrhea (17%)
    •Headache (9%)
    •Nausea or vomiting (8%)
    •Belly pain (7%)
    •Dizziness (6%)
    Common Side Effects for

    Type 2 diabetes (T2D)

    •Upper respiratory tract infection (up to 29%)
    •Swelling in the hands or feet (20%)
    •High blood pressure (20%)
    •Flu, sinus infections, or bronchitis (up to 19%)
    •Cataract (15%)
    •Joint pain (14%)
    •Pain in the hands and feet (13%)
    •Back pain (13%)
    •Cough (12%)
    •Urinary tract infection (11%)
    •Diarrhea (11%)
    •Depression (11%)
    •Headache (10%)

    Note: People with T1D typically experienced less side effects than people with T2D, but are at higher risk for hypoglycemia.

  • Warnings of Glucovance vs. Lantus

    Common Side Effects for
    •Lactic acidosis (too much acid in your body)
    •Low blood sugar
    •Possible risk of serious heart problems
    •Risk of low red blood cell count (hemolytic anemia)
    •Low vitamin B12 levels
    Common Side Effects for
    •Risk of serious infections
    •Risk of high and low blood sugar levels
    •Dangerously low blood sugar levels (hypoglycemia)
    •Low blood potassium levels
    •Swelling and heart failure
    •Severe allergic reactions

  • Prices with our coupons for Glucovance vs. Lantus

    Learn more about Glyburide/metformin
    Learn more about Lantus

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