Key takeaways
Alogliptin (Nesina) and Afrezza (insulin) are medications used to help manage diabetes, but they work in different ways. Alogliptin (Nesina) is a dipeptidyl peptidase-4 (DPP-4) inhibitor taken once daily to treat Type 2 diabetes by helping your body produce more insulin and less sugar. It doesn't cause significant changes in your body weight and is available as a lower-cost generic. On the other hand, Afrezza (insulin) is a fast-acting insulin inhaled through the mouth before meals to help lower blood sugar in adults with Type 1 or Type 2 diabetes. It starts working in about 12 minutes and lasts for 1.5 to 3 hours. Afrezza (insulin) is a good option if you prefer not to use injections, but it can't be used if you have breathing problems like asthma or chronic obstructive pulmonary disease (COPD). Common side effects of alogliptin include headaches and common cold symptoms (such as sneezing or runny nose), while Afrezza can cause low blood sugar, cough, and throat irritation. Additionally, Afrezza is not recommended if you smoke or have recently quit smoking.
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