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Compare Nesina vs. Glyburide

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Alogliptin (Nesina) and glyburide (Glynase) are both medications used to treat Type 2 diabetes, but they work in different ways and have distinct characteristics. Alogliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that helps lower blood sugar by allowing insulin to stay in your body longer and reducing sugar production. It is typically taken once daily and is available in a lower-cost generic form. Glyburide is a sulfonylurea that lowers blood sugar by signaling your pancreas to release more insulin. It can be taken once or twice daily, depending on your dose, and also has a generic version. While alogliptin isn't a first-choice treatment and doesn't significantly affect weight, glyburide can lower A1C levels more effectively but carries a higher risk of causing low blood sugar and potential weight gain. Serious side effects of glyburide include severe low blood sugar (hypoglycemia) and possible heart problems, while taking alogliptin may cause issues like severe joint pain and pancreatitis.

  • Alogliptin (Nesina)
    Glyburide
  • Alogliptin (Nesina)
    Glyburide

  • Summary of Nesina vs. Glyburide

    Summary for DDP-4 inhibitor
    Prescription only

    Alogliptin (Nesina) is a medication that treats Type 2 diabetes. It's added to diet and exercise to help lower your blood sugar levels. But it isn't a first-choice treatment for this condition. Alogliptin (Nesina) is typically taken by mouth once a day. Some people may experience certain side effects, such as headaches or symptoms of the common cold (e.g., sore throat or runny nose), after starting this medication.

    Summary for Sulfonylurea
    Prescription only

    Glyburide is taken by mouth to lower blood sugar levels for people who have Type 2 diabetes. This medication isn't meant to be taken alone, but in addition to eating a healthy diet and engaging in regular exercise. Glyburide is typically taken once or twice daily, depending on your dose.

  • Indications of Nesina vs. Glyburide

    Indications for
    •Type 2 diabetes
    Indications for
    •Type 2 diabetes

  • Pros and Cons of Nesina vs. Glyburide

    Pros and Const for DDP-4 inhibitor
    Pros
    •Taken once daily by mouth
    •Can be taken with or without food
    •Is available as a lower-cost generic
    Cons
    •Dose may change if you have kidney problems, while other similar medications, like Tradjenta (linagliptin), don't need dose changes
    •Not a first-choice treatment for Type 2 diabetes
    •Isn’t approved for Type 1 diabetes
    Pros and Const for Sulfonylurea
    Pros
    •Usually taken only once daily with largest meal
    •Can lower A1C levels by 1.5%
    •Taken by mouth, so good option for people who don't like injections
    •Can be taken with some other blood sugar medications, such as metformin
    Cons
    •Risk of low blood sugar (hypoglycemia), especially if you have kidney or liver problems
    •More likely to cause low blood sugar than other blood sugar medications, such as metformin
    •Can cause some weight gain
    •Not approved for Type 1 diabetes

  • Common Side Effects of Nesina vs. Glyburide

    Common Side Effects for
    •Upper respiratory tract infection (5%)
    •Common cold (5%)
    •Headache (4%)
    Common Side Effects for
    •Feeling bloated
    •Nausea
    •Heartburn

  • Warnings of Nesina vs. Glyburide

    Common Side Effects for
    •Heart failure
    •Severe joint pain
    •Inflammation of the pancreas
    •Liver problems
    •Severe itching rash
    Common Side Effects for
    •Low blood sugar (hypoglycemia)
    •Possible risk of heart problems
    •Breakdown of red blood cells

  • Prices with our coupons for Nesina vs. Glyburide

    Learn more about Alogliptin
    Learn more about Glyburide

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