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Compare Glyburide vs. Janumet

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Glyburide (Glynase) and Janumet (sitagliptin/metformin) are medications used to manage Type 2 diabetes. Both medications work in different ways to lower blood sugar, and have other differences between them. Glyburide helps your pancreas release more insulin, while Janumet combines sitagliptin and metformin to lower blood sugar by reducing sugar production in the liver and improving insulin sensitivity. Glyburide is typically taken once or twice daily with meals, whereas Janumet's immediate-release form is taken twice daily, and its extended-release form is taken once daily. Glyburide can cause low blood sugar and weight gain, while Janumet is less likely to cause these issues but can lead to gastrointestinal (gi) side effects like diarrhea. Janumet is not yet available as a generic, whereas glyburide is available as a lower-cost generic. Both medications require a prescription and should be used alongside a healthy diet and regular exercise.

  • Glyburide
    Janumet (sitagliptin / metformin)
  • Glyburide
    Janumet (sitagliptin / metformin)

  • Summary of Glyburide vs. Janumet

    Summary for Sulfonylurea
    Prescription only

    Glyburide is taken by mouth to lower blood sugar levels for people who have Type 2 diabetes. This medication isn't meant to be taken alone, but in addition to eating a healthy diet and engaging in regular exercise. Glyburide is typically taken once or twice daily, depending on your dose.

    Summary for DPP-4 inhibitor / Biguanide
    Prescription only

    Janumet (sitagliptin / metformin) is a medication for adults with Type 2 diabetes. It contains two different diabetes medications that work together to help control blood sugar. One is sitagliptin, a DPP-4 inhibitor, and the other is metformin, a biguanide. The Janumet immediate-release tablets are taken by mouth twice a day. It works best when used with a balanced meal plan and exercise routine. Some side effects are diarrhea, upper respiratory tract infection, and headache. There's only a brand-name version of Janumet; there's no generic version yet.

  • Indications of Glyburide vs. Janumet

    Indications for
    •Type 2 diabetes
    Indications for
    •Type 2 diabetes

  • Pros and Cons of Glyburide vs. Janumet

    Pros and Const for Sulfonylurea
    Pros
    •Usually taken only once daily with largest meal
    •Can lower A1C levels by 1.5%
    •Taken by mouth, so good option for people who don't like injections
    •Can be taken with some other blood sugar medications, such as metformin
    Cons
    •Risk of low blood sugar (hypoglycemia), especially if you have kidney or liver problems
    •More likely to cause low blood sugar than other blood sugar medications, such as metformin
    •Can cause some weight gain
    •Not approved for Type 1 diabetes
    Pros and Const for DPP-4 inhibitor / Biguanide
    Pros
    •Combines the effects of two diabetes medications into one tablet
    •Less likely to cause weight gain and low blood sugar compared to other diabetes medications
    •Can lower A1C by up to 2% in 6 months
    Cons
    •Must take twice a day with meals
    •Only available as a fixed dose, so can be hard to make dose adjustments
    •Not a good option for people with severe kidney problems
    •Not approved for people with Type 1 diabetes

  • Common Side Effects of Glyburide vs. Janumet

    Common Side Effects for
    •Feeling bloated
    •Nausea
    •Heartburn
    Common Side Effects for
    •Diarrhea (8%)
    •Upper respiratory tract infection (6%)
    •Headache (6%)

  • Warnings of Glyburide vs. Janumet

    Common Side Effects for
    •Low blood sugar (hypoglycemia)
    •Possible risk of heart problems
    •Breakdown of red blood cells
    Common Side Effects for
    •Lactic acidosis
    •Inflammation of the pancreas (pancreatitis)
    •Risk of heart failure
    •Sudden kidney problems
    •Low vitamin B12 levels
    •Low blood sugar (hypoglycemia) when taken with certain diabetes medications
    •Joint pain
    •Severe skin reaction
    •Serious allergic reactions

  • Prices with our coupons for Glyburide vs. Janumet

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    Learn more about Janumet

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