Compare Glyburide vs. Janumet

Glyburide (Glynase) and Janumet (sitagliptin/metformin) are medications used to manage Type 2 diabetes. Both medications work in different ways to lower blood sugar, and have other differences between them. Glyburide helps your pancreas release more insulin, while Janumet combines sitagliptin and metformin to lower blood sugar by reducing sugar production in the liver and improving insulin sensitivity. Glyburide is typically taken once or twice daily with meals, whereas Janumet's immediate-release form is taken twice daily, and its extended-release form is taken once daily. Glyburide can cause low blood sugar and weight gain, while Janumet is less likely to cause these issues but can lead to gastrointestinal (gi) side effects like diarrhea. Janumet is not yet available as a generic, whereas glyburide is available as a lower-cost generic. Both medications require a prescription and should be used alongside a healthy diet and regular exercise.