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Compare Starlix vs. Glyburide

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Nateglinide (formerly Starlix) and glyburide (Glynase) are both oral medications used to manage Type 2 diabetes, but they belong to different classes and have distinct characteristics. Nateglinide needs to be taken three times a day before meals and works by quickly stimulating the pancreas to release insulin, helping to control blood sugar levels after meals. Glyburide, on the other hand, is typically taken once or twice daily with the first main meal. Like nateglinide, it also stimulates the release of insulin in the pancreas but does it in a different way. Glyburide can lower A1C levels by 1.5%, which is higher than the 0.75% reduction seen with nateglinide. Both medications can cause low blood sugar, but glyburide has a higher risk, especially in older adults or those with kidney or liver issues. On the other hand, nateglinide is more likely than glyburide of causing weight gain. Additionally, glyburide has a potential risk of heart problems and hemolytic anemia.

  • Nateglinide
    Glyburide
  • Nateglinide
    Glyburide

  • Summary of Starlix vs. Glyburide

    Summary for Meglitinide
    Prescription only

    Nateglinide is an add-on medication to diet and exercise to control blood sugar in people with Type 2 diabetes. This medication comes as a tablet that's taken by mouth. It must be taken three times a day, which might be inconvenient for some people.

    Summary for Sulfonylurea
    Prescription only

    Glyburide is taken by mouth to lower blood sugar levels for people who have Type 2 diabetes. This medication isn't meant to be taken alone, but in addition to eating a healthy diet and engaging in regular exercise. Glyburide is typically taken once or twice daily, depending on your dose.

  • Indications of Starlix vs. Glyburide

    Indications for
    •Type 2 diabetes
    Indications for
    •Type 2 diabetes

  • Pros and Cons of Starlix vs. Glyburide

    Pros and Const for Meglitinide
    Pros
    •Helps release insulin into the body within 20 minutes of taking
    •Lowers A1C levels by around 0.75%
    •Good option if you can't take metformin because of side effects or poor kidney function
    •Lower-cost generic available
    Cons
    •Need to take 1 to 30 minutes before each meal
    •Must take 3 times a day, which can be inconvenient
    •Might be more likely to cause weight gain than other diabetes medications
    •Not for people with Type 1 diabetes
    Pros and Const for Sulfonylurea
    Pros
    •Usually taken only once daily with largest meal
    •Can lower A1C levels by 1.5%
    •Taken by mouth, so good option for people who don't like injections
    •Can be taken with some other blood sugar medications, such as metformin
    Cons
    •Risk of low blood sugar (hypoglycemia), especially if you have kidney or liver problems
    •More likely to cause low blood sugar than other blood sugar medications, such as metformin
    •Can cause some weight gain
    •Not approved for Type 1 diabetes

  • Common Side Effects of Starlix vs. Glyburide

    Common Side Effects for
    •Upper respiratory tract infection (11%)
    •Back pain (4%)
    •Flu symptoms (4%)
    •Dizziness (4%)
    •Joint problems (3%)
    •Diarrhea (3%)
    •Accidental trauma (3%)
    •Bronchitis (3%)
    Common Side Effects for
    •Feeling bloated
    •Nausea
    •Heartburn

  • Warnings of Starlix vs. Glyburide

    Common Side Effects for
    •Low blood sugar (hypoglycemia)
    Common Side Effects for
    •Low blood sugar (hypoglycemia)
    •Possible risk of heart problems
    •Breakdown of red blood cells

  • Prices with our coupons for Starlix vs. Glyburide

    Learn more about Nateglinide
    Learn more about Glyburide

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