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Compare Janumet vs. Prandin

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Janumet (sitagliptin/metformin) and repaglinide are both medications used to manage Type 2 diabetes, but they have some key differences. Janumet combines two medications: sitagliptin (a DPP-4 inhibitor) and metformin (a biguanide). It helps control blood sugar by improving insulin function and reducing glucose production and absorption. Janumet is taken either twice daily with meals (immediate-release) or once daily (extended-release). Repaglinide, on the other hand, is a meglitinide that stimulates the pancreas to produce more insulin and is taken before each meal. Unlike Janumet, repaglinide is available in a generic form. However, repaglinide can cause weight gain and has a higher risk of causing low blood sugar compared to Janumet. While Janumet is not recommended for those with severe kidney problems, repaglinide should not be used with NPH-insulin due to the risk of heart damage.

  • Janumet (sitagliptin / metformin)
    Repaglinide
  • Janumet (sitagliptin / metformin)
    Repaglinide

  • Summary of Janumet vs. Prandin

    Summary for DPP-4 inhibitor / Biguanide
    Prescription only

    Janumet (sitagliptin / metformin) is a combination prescription medication that helps improve blood sugar control in adults with Type 2 diabetes. It contains two diabetes medications from different drug classes: sitagliptin (a DPP-4 inhibitor) and metformin (a biguanide). Janumet (sitagliptin / metformin) is used as an add-on to diet and exercise. Immediate-release tablets (Janumet) are taken by mouth twice daily, and extended-release tablets (Janumet XR) are taken just once daily. Side effects include diarrhea, upper respiratory tract infection, and headache.

    Summary for Glinide
    Prescription only

    Repaglinide is an oral tablet taken in addition to diet and exercise to control blood sugar in adults with Type 2 diabetes. It belongs to the drug class called meglitinide, and works similar to sulfonylureas. The usual dosing is to take 0.5 mg to 4 mg by mouth before each meal. Potential warnings and side effects include low blood sugar, headache, and diarrhea. The brand name Prandin has been discontinued, but this medication is still available as a generic.

  • Indications of Janumet vs. Prandin

    Indications for
    •Type 2 diabetes
    Indications for
    •Type 2 diabetes

  • Pros and Cons of Janumet vs. Prandin

    Pros and Const for DPP-4 inhibitor / Biguanide
    Pros
    •Combines the effects of two medications into one tablet
    •Lowered A1C by up to 2% in a 6-month clinical study
    •Might be a good option for additional blood sugar control for people who don't like injections (such as with insulin)
    •Less likely to cause weight gain and low blood sugar compared to other diabetes medications
    Cons
    •Not yet available as a lower-cost generic
    •Must take with meals
    •Only available as a fixed dose, so can be hard to make dose adjustments
    •Side effects more likely if you're 65 years or older
    •Not a good option for people with severe kidney problems
    Pros and Const for Glinide
    Pros
    •Can quickly lower blood sugar during meal times
    •Comes as an oral tablet taken by mouth
    •Available as a lower-cost generic
    Cons
    •Has a risk of low blood sugar
    •Can cause some weight gain
    •Can interact with many medications

  • Common Side Effects of Janumet vs. Prandin

    Common Side Effects for
    •Diarrhea (8%)
    •Upper respiratory tract infection (6%)
    •Headache (6%)
    Common Side Effects for
    •Low blood sugar (31%)
    •Upper respiratory infection (16%)
    •Headache (11%)
    •Sinus infection (6%)
    •Joint pain (6%)
    •Nausea (5%)
    •Diarrhea (5%)
    •Back pain (5%)

  • Warnings of Janumet vs. Prandin

    Common Side Effects for
    •Lactic acidosis
    •Pancreas problems
    •Heart failure
    •Sudden kidney problems
    •Low vitamin B12 levels
    •Low blood sugar (hypoglycemia)
    •Joint pain
    •Severe skin reaction
    •Severe allergic reaction
    Common Side Effects for
    •Low blood sugar
    •Possible risk of serious heart problems

  • Prices with our coupons for Janumet vs. Prandin

    Learn more about Janumet
    Learn more about Repaglinide

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